A5054167462- Phytochemicals and Antioxidant Activities
- Food composition and properties
- Antioxidant Activity and Oxidative Stress
- Polysaccharides Composition and Applications
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Fermentation and Sensory Analysis
- Microbial Metabolites in Food Biotechnology
- Polysaccharides and Plant Cell Walls
- Plant Pathogens and Fungal Diseases
- Protein Hydrolysis and Bioactive Peptides
- Plant and fungal interactions
- Essential Oils and Antimicrobial Activity
- Proteins in Food Systems
- Cancer-related molecular mechanisms research
- Curcumin's Biomedical Applications
- Phytochemistry and Biological Activities
- Plant Gene Expression Analysis
- Biochemical effects in animals
- Nutrition and Health in Aging
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Free Radicals and Antioxidants
- Plant-derived Lignans Synthesis and Bioactivity
- Meat and Animal Product Quality
Jiangsu Academy of Agricultural Sciences
2016-2025
Harvard University
2025
Massachusetts General Hospital
2025
Jiangsu University
2019-2025
Nanjing Forestry University
2023-2025
The University of Queensland
2025
National Health and Medical Research Council
2025
Nanjing Agricultural University
2025
Central South University
2008-2023
Second Xiangya Hospital of Central South University
2009-2023
Blueberries possess abundant anthocyanins, which benefit eye health. The purpose of this study was to explore the protective functional role blueberry anthocyanin extract (BAE) and its predominant constituents, malvidin (Mv), malvidin-3-glucoside (Mv-3-glc), malvidin-3-galactoside (Mv-3-gal), on high glucose- (HG-) induced injury in human retinal capillary endothelial cells (HRCECs). results showed that BAE, Mv, Mv-3-glc, Mv-3-gal enhanced cell viability (P < 0.05 versus HG group at 24 h);...
Blueberry fruits have a wide range of health benefits because their abundant anthocyanins, which are natural antioxidants. The purpose this study was to investigate the inhibitory effect blueberry's two main anthocyanins (malvidin-3-glucoside and malvidin-3-galactoside) on inflammatory response in endothelial cells. These malvidin glycosides could inhibit tumor necrosis factor-alpha (TNF-α) induced increases monocyte chemotactic protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1),...
To determine whether and how exosomes from human umbilical vein endothelial cells (HUVEC-Exos) regulates vascular smooth muscle (VSMCs) calcification/senescence in high glucose condition. HUVEC-Exos were isolated normal (NG) (HG) stimulated HUVECs (NG/HG-HUVEC-Exos) by super speed centrifugation. identified transmission electron microscopy Western blot of CD63. Protein profile was examined to screen the candidate molecules that mediate function. VSMCs incubated with HUVEC-Exos. A series...
The aim was to apply AWGS criteria estimate the prevalence of sarco-osteoporosis and investigate its relationship with frailty, in a sample 316 community-dwelling Chinese older people. Regression analysis performed using frailty as dependent variable. results showed that rate 10.4% men 15.1% women. ≧80 years old (OR 4.8; 95% CI, 3.05–10.76;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.027</mml:mn></mml:math>), women 2.6;...
The objective of this research was to survey the antioxidant functional role main anthocyanins blueberries in endothelial cells. Changes on reactive oxygen species (ROS), xanthine oxidase‐1 (XO‐1), superoxide dismutase (SOD), and heme oxygenase‐1 (HO‐1) cells malvidin two glycosides were investigated. results showed that these decreased levels ROS XO‐1 but increased SOD HO‐1. Glycosides improved capacity a great extent. changes properties malvidin‐3‐glucoside more pronounced than...
Blueberry anthocyanins are considered protective of eye health because their recognized antioxidant properties. In this study, blueberry anthocyanin extract (BAE), malvidin (Mv), malvidin-3-glucoside (Mv-3-glc), and malvidin-3-galactoside (Mv-3-gal) all reduced H2O2-induced oxidative stress by decreasing the levels reactive oxygen species malondialdehyde increasing superoxide dismutase, catalase, glutathione peroxidase in human retinal pigment epithelial cells. BAE standards enhanced cell...
Blueberries are rich in bioactive anthocyanins, with a high level of malvidin, which is associated antioxidant benefits that contribute to reducing the risk diabetes. The objective this study was investigate hypoglycemic and hypolipidemic effects blueberry anthocyanin extract (BAE), malvidin (Mv), malvidin-3-glucoside (Mv-3-glc), malvidin-3-galactoside (Mv-3-gal) both human hepatocarcinoma cell line HepG2 high-fat diet combining streptozotocin-induced diabetic mice. High glucose treatment...
Oxidative stress and vascular inflammatory response are key mediators of endothelial dysfunction that leads to cardiovascular diseases. A novel peptide, IRW, was previously characterized from egg protein with angiotensin converting enzyme inhibitory activity. The purpose the study investigate effects molecular mechanisms IRW on regulating in cells. results showed tumor necrosis factor-α (TNF-α) significantly increased levels intercellular adhesion molecule-1 (ICAM-1), cell (VCAM-1), monocyte...
The total phenolic content (TFC), flavonoid antioxidant activity, and polyphenol composition of extracts rabbiteye blueberry fruit polyphenols (BBFPs), pomace (BBPPs), leaves (BBLPs) were investigated. highest TPC TFC found in the extract BBLPs, followed by BBPPs BBFPs. BBLPs exhibited activity according to five methods. All three samples significantly higher than positive control rutin. HPLC–DAD–MSn analysis showed that BBFPs contained nine different anthocyanins, while only four them. In...