A5077809859- melanin and skin pigmentation
- RNA regulation and disease
- Biochemical Analysis and Sensing Techniques
- Skin Protection and Aging
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Diet and metabolism studies
- Acne and Rosacea Treatments and Effects
- Dyeing and Modifying Textile Fibers
- Genetic Neurodegenerative Diseases
- Connexins and lens biology
- DNA Repair Mechanisms
- RNA Research and Splicing
- CAR-T cell therapy research
- Pharmacological Effects of Medicinal Plants
- RNA and protein synthesis mechanisms
- Acute Lymphoblastic Leukemia research
- Digestive system and related health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Liver Diseases and Immunity
- Cutaneous Melanoma Detection and Management
- Neurological diseases and metabolism
- Skin and Cellular Biology Research
Nagoya University
1992-2018
University of California, Davis
2009-2016
Kazusa DNA Research Institute
2013
University of California Davis Medical Center
2010-2011
National Institutes of Health
2006-2010
National Cancer Institute
2006-2010
Cancer Institute (WIA)
2007
Tohoku University
1993-1998
Akita University
1997-1998
The whole-genome sequence of carnation (Dianthus caryophyllus L.) cv. 'Francesco' was determined using a combination different new-generation multiplex sequencing platforms. total length the non-redundant sequences 568,887,315 bp, consisting 45,088 scaffolds, which covered 91% 622 Mb genome estimated by k-mer analysis. N50 values contigs and scaffolds were 16,644 bp 60,737 respectively, longest scaffold 1,287,144 bp. average GC content contig 36%. A 1050, 13, 92 143 genes for tRNAs, rRNAs,...
The relationship between human skin pigmentation and protection from ultraviolet (UV) radiation is an important element underlying differences in carcinogenesis rates. association UV damage the risk of cancer clear, yet a strategic balance exposure to needs be met. Dark protected UV-induced DNA significantly more than light owing constitutively higher pigmentation, but as unresolved question what photoprotective benefit, if any, afforded by facultative (i.e. tan induced exposure). To address...
Treatments for primary and metastatic melanomas are rarely effective. Even therapeutics such as retinoic acid (RA) that successfully used to treat several other forms of cancer ineffective. Recent evidence indicates the antiproliferative effects RA mediated by transcription factor SOX9 in human cell lines. As we have previously shown is expressed normal melanocytes, here investigated expression function melanomas. Although was skin, it increasingly downregulated melanocytes progressed...
Effects of ionizing radiation on the level genomic DNA methylation in liver, brain and spleen mouse as well two kinds cultured cells were examined by high-performance liquid chromatography. Ten Gy whole body X-radiation reduced 5-methyldeoxycytidine contents about 40% within 8 hours after irradiation liver. Similar effects observed at 4 or 7 X-ray irradiation. However, no such change was detected brain, cells. The data indicate that radiation-induced alteration is not ubiquitous among...
It is widely accepted that central and effector memory CD4+ T cells originate from naïve after they have encountered their cognate antigen in the setting of appropriate co-stimulation. However, if this were true diversity cell receptor (TCR) sequences within compartment should be far greater than compartment, which not supported by TCR sequencing data. Here we demonstrate aged mice with fewer cells, respond to model antigen, hen eggwhite lysozyme (HEL), utilizing same sequence as younger...
There are limited treatment options for metastatic melanoma, which is almost universally fatal. We report the successful of 64 cutaneous and subcutaneous melanoma metastases in three patients using high-dose (22 million units per 1.2 ml) intralesional interleukin 2 (IL-2) combination with topical imiquimod a retinoid cream. Before therapy, all had been treated surgically were no longer considered surgical candidates. Rebiopsy 15 sites long-term follow-up (10, 12, 27 months) showed regression...
Abstract CTLA-4 is known as a central inhibitor of T cell responses. It terminates activation and proliferation induces resistance against induced death. However, its impact on memory formation adaptive immune responses still unknown. In this study, we demonstrate that although anti–CTLA-4 mAb treatment during primary immunization mice initially enhances the number IFN-γ–producing CD4+ cells, it does not affect size pool. Interestingly, find blockade modulates quality pool: decreases amount...
The molecular bases of various types congenital hypopigmentary disorders have been clarified in the past 10 years. Homozygous gene mutations enzymes functional melanogenesis such as tyrosinase, P protein and DHICA oxidase, result oculocutaneous albinism (OCA) 1, OCA 2, 3, respectively. genes responsible for Hermansky-Pudlak syndrome (HPS) Chediak-Higashi (CHS) also recently isolated cloned. transcription factor paired box 3 (PAX3) works at promoter region microphthalmia-associated (MITF)...
<b>Background:</b> Yellow oculocutaneous albinism (OCA) that is caused by tyrosinase gene mutations shows two characteristics: extreme hypopigmentation at birth and the eventual development of yellow or blond hair. <b>Objective:</b> We studied a Japanese girl who had brown hair, lighter skin color than her unaffected family eyes 9 months age. <b>Methods:</b> performed direct sequencing analyses in genomic DNA. <b>Results:</b> The patient was...
A large number of mutations the tyrosinase gene result in oculocutaneous albinism (OCA). Therefore, at present, sequence analysis has become necessary to diagnose OCA patients and their relatives.The aim this study was facilitate sequence-based diagnosis tyrosinase-related by using small amounts patient's blood.Blood spots dried on filter papers were used as sources genomic DNA. The exons flanking regions amplified polymerase chain reaction (PCR) directly sequenced both directions.We...
To determine the role that competition plays in a molecular mimic’s capacity to induce autoimmunity, we studied ability of naïve encephalitogenic T cells expand response agonist altered peptide ligands (APLs), some capable stimulating both self-directed and exclusively APL-specific cells. Our results show although APLs are able vitro, repertoire is effectively outcompeted vivo when APL used as priming immunogen. Competition mechanism was supported by: ( i ) demonstration population cells, ii...