A5100365543- Extracellular vesicles in disease
- Sulfur Compounds in Biology
- Neonatal Respiratory Health Research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- Wound Healing and Treatments
- Catalytic Alkyne Reactions
- Fibroblast Growth Factor Research
- Nanoplatforms for cancer theranostics
- Hemoglobin structure and function
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Neuroscience of respiration and sleep
- Ion Channels and Receptors
- Air Quality and Health Impacts
- Cancer Cells and Metastasis
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Molecular Sensors and Ion Detection
Affiliated Hospital of Nantong University
2025
Nantong University
2025
Wenzhou Medical University
2019-2024
First Affiliated Hospital of Wenzhou Medical University
2019-2024
Sichuan University
2022
West China Hospital of Sichuan University
2022
Army Medical University
2020-2021
Army Medical College
2020
Shanghai Institute of Organic Chemistry
2018
University of Chinese Academy of Sciences
2018
Quick: An exogenously induced quick increase of the H2S concentration (80 s) in MCF-7 cells can be visualized by ratiometric imaging using a new probe (CouMC) that target mitochondria. CouMC was constructed combining merocyanine and coumarin fluorophores. The selective nucleophilic addition HS− to derivative at neutral pH is crucial for rapid detection. As service our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may...
Metformin is currently the most prescribed oral agent for diabetes treatment; however overdose or long-term use may cause some severe side effects such as liver injury.Researches indicate that metformin-induced injury closely related to upregulation of hepatic H 2 S. Hence, monitoring S generation induced by metformin could be an effective approach evaluating hepatoxicity drug.Methods: We present a novel turn-on and dual-mode probe detecting imaging specifically tracking with fluorescent...
A Pd(OAc)2-catalyzed asymmetric cyclization of 2-aminoaryl alkynones involving an intramolecular trans-aminopalladation alkyne and 1,2-addition to the carbonyl group tandem processes was developed. This strategy represents first example using palladium as catalyst 2-alkynylaniline derivatives starting material allow facile access chiral 1,2,3,4-tetrahydro-β-carbolines in high yields excellent enantioselectivities.
Summary Background SARS-CoV-2 has been a global pandemic, but the emergence of asymptomatic patients caused difficulties in prevention epidemic. Therefore, it is significant to understand epidemiological characteristics with infection. Methods In this single-center, retrospective and observational study, we collected data from 167 infection treated Chongqing Public Health Medical Center (Chongqing, China) January March 2020. The variable these were analyzed. Findings 82.04% infected had...
Abstract Particulate matter (PM) is an environmental pollutant closely associated with human airway inflammation. However, the molecular mechanisms of PM-related inflammation remains to be fully elucidated. It known that COX-2/PGE 2 play key roles in pathogenesis Filaggrin a transmembrane protein contributing tight junction barrier function. As such, prevents leakage transported solutes and therefore necessary for maintenance epithelial integrity. The objective present study was investigate...
Small-diameter tissue-engineered vascular grafts (sdTEVGs) with hyperglycemia resistance have not been constructed. The intimal hyperplasia caused by remains problem to hinder the patency of sdTEVGs. Here, inspired bionic regulation nerve on vascular, we found released neural exosomes could inhibit abnormal phenotype transformation smooth muscle cells (VSMCs). was a prime culprit causing To address this concern, sdTEVGs were modified an on-demand programmable dual-responsive system ultrathin...
Abstract Background SARS-CoV-2 has been a global pandemic, but the emergence of asymptomatic patients caused difficulties in prevention epidemic. Therefore, it is significant to understand epidemiological characteristics with infection. Methods In this single-center, retrospective and observational study, we collected data from 167 infection treated Chongqing Public Health Medical Center (Chongqing, China) January March 2020. The variable these were analyzed. Findings 82.04% infected had...
It has been proposed that repeated exposure of bronchial epithelial cells to atmospheric particulate matter (PM) could disrupt airway integrity and lead epithelial-to-mesenchymal transition (EMT) ultimately remodeling. The molecular mechanisms underlying PM-related EMT have not yet elucidated. aim this research is clarify the mechanism upon PM exposure. Using an in vivo mouse model PM-induced inflammation vitro PM-stimulated cells, we clarified role haptoglobin (HP) EMT. expression HP lung...
Objective Both human glioma stem cell line SU3 transfected with red fluorescent protein(SU3-RFP)and bone marrow cells from green fluorescence protein(GFP)transgenic athymic nude mice were transplanted into damage-reconstitution Balb/c to investigate the mutual interactions between mesenchymal cells(BMSCs)and SU3-RFP in vivo. Methods After irradiation of mice, allogeneic transplantation GFP+ was performed via caudal vein establish models. subcutaneously models and xenograft tumors...
<p>PDF file - 300K, Effect of PNUTS interaction on PTEN localization and stability</p>