A5059748284- Air Quality and Health Impacts
- Energy and Environment Impacts
- Effects and risks of endocrine disrupting chemicals
- Urban Transport and Accessibility
- Air Quality Monitoring and Forecasting
- Climate Change and Health Impacts
- Health, Environment, Cognitive Aging
- Computational Drug Discovery Methods
- Energy, Environment, and Transportation Policies
- Municipal Solid Waste Management
- Chemical Safety and Risk Management
- Classical Antiquity Studies
- Atmospheric chemistry and aerosols
- Vehicle emissions and performance
- Chemistry and Chemical Engineering
- History and advancements in chemistry
- Organic Chemistry Synthesis Methods
- Toxic Organic Pollutants Impact
- Environmental Impact and Sustainability
- Noise Effects and Management
- Advanced Chemical Sensor Technologies
- Social Acceptance of Renewable Energy
- Indoor Air Quality and Microbial Exposure
- Animal testing and alternatives
- Evacuation and Crowd Dynamics
Environmental Protection Agency
2014-2023
Research Triangle Park Foundation
2013-2023
Harvard University
2008-2016
Harvard Global Health Institute
2008-2016
Triangle
2016
VA Office of Research and Development
2013-2016
University of Ghana
2010
The U.S. Environmental Protection Agency (EPA) is faced with the challenge of efficiently and credibly evaluating chemical safety often limited or no available toxicity data. expanding number chemicals found in commerce environment, coupled time resource requirements for traditional testing exposure characterization, continue to underscore need new approaches. In 2005, EPA charted a course address this by embracing computational toxicology (CompTox) investing technologies capabilities push...
Quantitative data on product chemical composition is a necessary parameter for characterizing near-field exposure. This set comprises reported and predicted information more than 75,000 chemicals 15,000 consumer products. The data's primary intended use exposure, risk, safety assessments. includes specific products with quantitative or qualitative ingredient information, which has been publicly disclosed through material sheets (MSDS) lists. A single category from refined harmonized of...
The risk posed to human health by any of the thousands untested anthropogenic chemicals in our environment is a function both hazard presented chemical and extent exposure. However, many lack estimates exposure intake, limiting understanding risks. We aim develop rapid heuristic method determine potential for application with little or no data. used Bayesian methodology infer ranges consistent biomarkers identified urine samples from U.S. population National Health Nutrition Examination...
Humans are exposed to thousands of chemicals in the workplace, home, and via air, water, food, soil. A major challenge estimating chemical exposures is understand which present these media microenvironments. Here we describe Chemical/Product Categories Database (CPCat), a new, publically available (http://actor.epa.gov/cpcat) database information on mapped “use categories” describing usage or function chemical. CPCat was created by combining multiple diverse sources data consumer-...
Identifying chemicals that provide a specific function within product, yet have minimal impact on the human body or environment, is goal of most formulation chemists and engineers practicing green chemistry. We present methodology to identify potential chemical functional substitutes from large libraries using machine learning based models. collect analyze publicly available information in consumer products industrial processes suite harmonized categories suitable for modeling. use...
This study examined the spatial, socioeconomic status (SES), and temporal patterns of ambient air pollution in Accra, Ghana. Over 22 months, integrated continuous rooftop particulate matter (PM) monitors were placed at a total 11 residential or roadside monitoring sites four neighborhoods varying SES biomass fuel use. PM concentrations highest late December January, due to dust blown from Sahara. Excluding this period, annual PM2.5 ranged 39 53 μg/m3 30 70 sites; mean PM10 80 108 57 106...
BackgroundSources of air pollution in developing country cities include transportation and industrial pollution, biomass coal fuel use, resuspended dust from unpaved roads.ObjectivesOur goal was to understand within-neighborhood spatial variability particulate matter (PM) communities varying socioeconomic status (SES) Accra, Ghana, quantify the effects nearby sources on local PM concentration.MethodsWe conducted 1 week morning afternoon mobile stationary measurements four study...
Many urban households in developing countries use biomass fuels for cooking. The proportion of household varies among neighborhoods, and is generally higher low socioeconomic status (SES) communities. Little known how air pollution by SES it affected traffic sources country cities. In four neighborhoods Accra, Ghana, we collected analyzed geo-referenced data on community particulate matter (PM) pollution, SES, fuel domestic small-commercial cooking, housing characteristics, distance to major...
Particulate matter (PM) is an important metric for studying the health effects of household air pollution. There are limited data on PM exposure children in homes that use biomass fuels, and no previous study has used direct measurement personal younger than 5 years age. We estimated PM(2.5) 1266 The Gambia by applying cookhouse PM(2.5)-CO relationship to child's CO exposure. Using this indirect method, mean all subjects was 135 ± 38 μg/m(3); 25% had exposures 151 μg/m(3) or higher....
Household air pollution in sub-Saharan Africa and other developing regions is an important cause of disease burden. Little known about the chemical composition sources household Africa, how they differ between rural urban homes. We analyzed fine particles (PM2.5) cooking areas multiple neighborhoods Accra, Ghana, peri-urban (Banjul) (Basse) The Gambia. In biomass burning accounted for 39-62% total PM2.5 mass area different neighborhoods; absolute contributions were 10-45 μg/m(3). Road dust...
Low birthweight contributes to as many 60% of all neonatal deaths; exposure during pregnancy household air pollution has been implicated a risk factor. Between 2011 and 2013, we measured personal exposures carbon monoxide (CO) fine particulate matter (PM
Indoor air pollution (IAP) from biomass fuels contains high concentrations of health damaging pollutants and is associated with an increased risk childhood pneumonia. We aimed to design exposure measurement component for a matched case-control study IAP as factor pneumonia severe in infants children The Gambia. conducted co-located simultaneous area carbon monoxide (CO) particles aerodynamic diameter <2.5 microm (PM(2.5)) 13 households 48 h each. CO was measured using passive integrated...
The highest levels of air pollution in the world now occur developing country cities, where sources differ from high-income countries. We analyzed particulate matter (PM) chemical composition and estimated contributions various to particle poor affluent neighborhoods Accra, Ghana. Elements earth's crust were most abundant during seasonal Harmattan period between late December January when Saharan dust is carried coastal West Africa. During Harmattan, crustal particles accounted for 55 μg m−3...
A major challenge in traffic-related air pollution exposure studies is the lack of information regarding pollutant characterization. Air quality modeling can provide spatially and temporally varying estimates for examining relationships between pollutants adverse health outcomes. hybrid approach was used to estimate support Near-Road Exposures Effects Urban Pollutants Study (NEXUS) conducted Detroit (Michigan, USA). Model-based metrics, associated with local variations emissions meteorology,...
Background: Chemicals in consumer products are a major contributor to human chemical coexposures. Consumers purchase and use wide variety of containing potentially thousands chemicals. There is need identify potential real-world coexposures prioritize vitro toxicity screening. However, due the vast number combinations, this identification has been challenge. Objectives: We aimed develop implement data-driven procedure for identifying prevalent combinations which humans exposed through...
Life Cycle Assessment (LCA) is a decision-making tool that accounts for multiple impacts across the life cycle of product or service. This paper presents conceptual framework to integrate human health impact assessment with risk screening approaches extend LCA include near-field chemical sources (e.g., those originating from consumer products and building materials) have traditionally been excluded LCA. A new generation rapid exposure modeling high-throughput toxicity testing transforming...
Exposure to a chemical is critical consideration in the assessment of risk, as it adds real-world context toxicological information. Descriptions where and how individuals spend their time are important for characterizing exposures chemicals consumer products indoor environments. Herein we create an agent-based model (ABM) that simulates longitudinal patterns human behavior. By basing ABM upon artificial intelligence (AI) system, agents mimic decisions on performing behaviors relevant...