A5070600475- Cervical Cancer and HPV Research
- Head and Neck Cancer Studies
- Genital Health and Disease
- Colorectal and Anal Carcinomas
- Cytokine Signaling Pathways and Interactions
- Diverticular Disease and Complications
- Immune Response and Inflammation
- Anorectal Disease Treatments and Outcomes
- Herpesvirus Infections and Treatments
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Oral Health Pathology and Treatment
- Inflammatory Bowel Disease
- Cleft Lip and Palate Research
- Science and Education Research
- Immunotherapy and Immune Responses
- Diagnosis and treatment of tuberculosis
- Salivary Gland Tumors Diagnosis and Treatment
Instituto do Câncer do Estado de São Paulo
2020-2024
Universidade de São Paulo
2017-2023
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2021-2023
Universidade Brasil
2022
Universidade Federal de São Paulo
2003
Cervical cancer is the last stage of a series molecular and cellular alterations initiated with Human Papillomavirus (HPV) infection. The process involves immune responses evasion mechanisms, which culminates tolerance toward tumor antigens. Our objective was to understand local systemic changes in interactions between HPV associated cervical lesions system as progress cancer. Locally, we observed higher leukocyte infiltrate, reflected by increase frequency T lymphocytes, neutrophils M2...
Cutaneous warts are caused by human papillomavirus (HPV). To date, more than 120 different types of HPV known, which 80 have been completely characterized. Prevalence studies on present in cutaneous carried out immunocompetent individuals and immunosuppressed organ allograft recipients, but not immunodeficiency virus (HIV)-positive patients.To determine the HIV-infected patients.Twenty-five biopsies from patients 14 samples control non-HIV-infected were studied. detection was performed...
Abstract The present study aimed to evaluate the association of genital and oral HPV infection among different sexual practices in both sexes. In total, 6388 unvaccinated men women aged 16–25 years from all state capitals Brazil were enrolled through primary care services between September 2016 November 2017. Genital genotyping was performed using Roche Linear Array. Poisson regression analysis with robust variance conducted examine factors associated overall infection. A higher prevalence...
Transgender women (TGW) are susceptible to the acquisition of sexually transmitted infections (STIs), including human papillomavirus (HPV). Nonetheless, exact data for this population scarce. We estimated HPV positivity at anal, genital, and oral sites among TGW also identified related characteristics behaviors that could be risk factors infection in a sample Brazil. Furthermore, we characterized site-specific genotypes those who were positive these 3 sites.A cross-sectional study was...
The aim of this study was to compare the frequency dysplasia and human papillomavirus (HPV) infection in anal canal patients with Crohn's disease (CD) a control group assess whether there is correlation between use immunosuppressants manifestation CD. Patients CD individuals were submitted cytology material collection for polymerase chain reaction (PCR). classified as normal, atypical squamous cells undetermined significance (ASCUS), low-grade intraepithelial lesion (LSIL), or high-grade...
Perianal fistulizing Crohn's disease is the main risk factor for anal cancer in patients with inflammatory bowel disease. Whether this occurs due to a higher frequency of human papillomavirus remains unclear. The authors aimed evaluate prevalence HPV and high-risk perianal disease, compared control group. conducted two-center cross-sectional study which were matched age sex anorectal fistula without Biopsy specimens obtained from fistulous tracts during examination under anesthesia both...
Cervical cancer, which main etiologic factor is Human Papillomavirus (HPV) infection, continues to be a burden for public health systems in developing countries. Our laboratory has been working with the hypothesis that signals generated tumor microenvironment can modulate local and systemic immune responses. In this context, it would reasonable think tumors create pro-tumoral bias cells, even before they are recruited microenvironment. To understand if how signaling started influence cells...
Abstract Background Human papillomavirus (HPV)‐driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16 INK4a in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, Peru. Methods was genotyped by PCR‐hybridization. All positive some negative cases underwent immunohistochemistry. Results detected 32.8%, 11.1%, 17.8% of oropharyngeal (OPC), oral cavity (OCC) laryngeal (LC) cancers, respectively. OPC higher Colombia...
Background Advances in laboratory techniques for HPV diagnosis necessitate a thorough assessment of the efficiency, replicability, sensitivity, and specificity those methods. This study aims to validate compare detection/genotyping using Anyplex™ II HPV28 Detection assay (Seegene) Linear Array Genotyping test (Roche Diagnostics) on genital samples use epidemiological studies. Methods From 6,388 penile cervical DNA collected POP-Brazil, 1,745 were randomly selected be included this study. The...
Abstract Background Prophylactic HPV vaccination has been recommended for the prevention of cancers caused by infection. Nevertheless, may be reduce oral prevalence, putative precursor to squamous cell carcinoma. This study aimed report prevalence among vaccinated and unvaccinated women men aged 16 25 years who use public health system. Methods POP-Brazil is a cross-sectional, multicentric survey. Participants were recruited from 119 primary care units distributed throughout all 27 capitals...