A5080653454- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Biosimilars and Bioanalytical Methods
- COVID-19 Clinical Research Studies
- Diagnosis and treatment of tuberculosis
- Pharmaceutical studies and practices
- Immunodeficiency and Autoimmune Disorders
- Gastroesophageal reflux and treatments
- Liver Diseases and Immunity
- Tuberculosis Research and Epidemiology
- Autoimmune and Inflammatory Disorders
- COVID-19 and healthcare impacts
- Diverticular Disease and Complications
- Gut microbiota and health
- Mycobacterium research and diagnosis
- Health Systems, Economic Evaluations, Quality of Life
- Helicobacter pylori-related gastroenterology studies
- Pregnancy and Medication Impact
- Stoma care and complications
- Systemic Sclerosis and Related Diseases
- Colorectal and Anal Carcinomas
- Esophageal and GI Pathology
- SARS-CoV-2 and COVID-19 Research
- Adolescent and Pediatric Healthcare
Hospital de Santa Cruz
2023-2025
Pontifícia Universidade Católica do Paraná
2022-2024
Hospital Santa Paula
2022-2024
D’Or Institute for Research and Education
2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2019-2024
Universidade de São Paulo
2015-2023
Universidade Brasil
2020-2021
Hospital Universitário da Universidade de São Paulo
2021
Polydoro Ernani de São Thiago University Hospital
2020
Universidade Federal da Paraíba
2017
Inflammatory bowel diseases (IBD) are chronic conditions arising from an intricate interplay of genetics and environmental factors, associated with gut dysbiosis, inflammation, permeability. In this study, we investigated whether the inflammatory potential diet is microbiota profile, permeability in forty patients IBD clinical remission. The dietary index (DII) score was used to assess diet. fecal profile analyzed using 16SrRNA (V3-V4) gene sequencing, while zonulin calprotectin levels were...
Abstract Background Etiology of gastro‐esophageal reflux disease ( GERD ) is multifactorial, but incompetence the esophago‐gastric junction EGJ appears to be crucial importance. Established manometric parameters for assessment barrier function are sub‐optimal, potentially because they reflect only a very brief (up 30 seconds), not necessarily representative period. This prospective, case–control study tested performance novel, high‐resolution manometry HRM in . Methods Patients with symptoms...
Abstract Background The effectiveness of ustekinumab (UST) in the treatment Crohn’s disease (CD) has been demonstrated pivotal Phase 3 UNITI 1 and 2 IM-UNITI studies both anti-TNF-naïve anti-TNF-exposed patients. Given selective nature trial designs, real-world safety are warranted. We report our experience with UST a large, multicenter cohort Brazilian patients CD. Methods performed retrospective study including CD, predominantly biologically refractory who received UST. primary endpoint...
Abstract Background Real-world data on the effectiveness and safety of ustekinumab (UST) in ulcerative colitis (UC) are lacking Latin America. In this study, we aimed to describe UST a real-world multicenter cohort Brazilian patients with UC. Methods We conducted retrospective observational including moderate-to-severe UC (total Mayo score 6–12, an endoscopic subscore 2 or 3) who received UST. The co-primary endpoints were clinical remission, defined as total ≤2 at 1 year, combined rectal...
Low bone mineral density (BMD) and osteoporosis remain frequent problems in patients with inflammatory bowel diseases (IBDs). Several guidelines nonidentical recommendations exist there is no general agreement regarding the optimal approach for screening IBD patients. Clinical practice of treatment remains insufficiently investigated. In year 2014, a chart review 877 included Swiss Cohort study was performed to assess details diagnostics treatment. BMD measurements, treatment, medication...
As the patents for biologic originator drugs expire, biosimilars are emerging as cost-effective alternatives within healthcare systems. Addressing various challenges in clinical management of inflammatory bowel disease (IBD) remains crucial. To shed light on physicians' current knowledge, beliefs, practical approaches, and concerns related to biosimilar adoption-whether initiating a biosimilar, transitioning from an or switching between (including multiple switches reverse switching)-a...
Abstract Background Inflammatory bowel disease (IBD) is a chronic condition of the gastrointestinal tract characterised by recurring inflammation that usually requires life-long treatment. As therapeutic landscape rapidly expanding, there growing need to understand patient perceptions treatment-related attributes. This study explored preferences for treatment attributes in patients with Crohn’s (CD) or ulcerative colitis (UC) Brazil. Methods Adult from Argentina, Australia, Brazil, Saudi...
Low bone mineral density (BMD) remains a frequent problem in patients with inflammatory bowel diseases (IBD). There is no general agreement regarding osteoporosis screening IBD patients.Cases of low BMD and disease characteristics were retrieved from 3172 the Swiss cohort study. Multivariate logistic regression analysis was conducted for predictive modeling. In subgroup 877 patients, 253 dual-energy X-ray absorptiometry (DXA) scans available validation.Low prevalent 19% patients. We...
<b><i>Introduction:</i></b> Abdominal surgery in patients with Crohn’s disease (CD) is challenging, especially the biologic era. The aim of this study was to evaluate factors associated increased risk for postoperative complications CD. <b><i>Methods:</i></b> A retrospective conducted consecutive who underwent abdominal CD from January 2012 2018. <b><i>Results:</i></b> Of 103 patients, 32% had complications. Gender, age,...
One of the most impacted regions by pandemic globally, Latin America is facing socioeconomic and health-care challenges that can potentially affect disease outcomes. Recent data suggest inflammatory bowel (IBD) patients do not have an increased risk development COVID-19 complications. However, impact on IBD living in least developed areas remains to be fully elucidated. This study aims describe outcomes diagnosed with countries from based SECURE-IBD registry.Patients enrolled registry were...
Abstract Objective This study assessed whether high‐resolution manometry ( HRM ) with a test meal can detect clinically relevant, abnormal motility already in very early systemic sclerosis SS c) and this finding is associated subsequent disease progression. Methods prospective, longitudinal cohort recruited 68 consecutive c patients (group #1: 32 established ACR , American College of Rheumatology / EULAR The European League against Rheumatism 2013 1980 criteria fulfilled); group #2: 24 (only...
Therapeutic drug monitoring (TDM) during induction therapy with anti-tumor necrosis factor drugs has emerged as a strategy to optimize response these biologics and avoid undesired outcomes related inadequate exposure. This study aimed describe clinical, biological, endoscopic remission rates at six months in Brazilian inflammatory bowel disease (IBD) patients following proactive TDM algorithm guided by IFX trough levels (ITL) antibodies (ATI) induction, week six. A total of 111 IBD were...