A5033320164- Mosquito-borne diseases and control
- Species Distribution and Climate Change
- Phytoplasmas and Hemiptera pathogens
- Ecology and Vegetation Dynamics Studies
- Cardiac electrophysiology and arrhythmias
- Mathematical and Theoretical Epidemiology and Ecology Models
- Epilepsy research and treatment
- Insect symbiosis and bacterial influences
- Cardiovascular Effects of Exercise
- Animal Ecology and Behavior Studies
- Cocoa and Sweet Potato Agronomy
- Viral Infections and Vectors
- Cardiac Arrhythmias and Treatments
- Pharmacological Effects and Toxicity Studies
- Evolution and Genetic Dynamics
- Insect behavior and control techniques
- Vector-Borne Animal Diseases
- Cardiac pacing and defibrillation studies
- Malaria Research and Control
- Plant and animal studies
- Neonatal and fetal brain pathology
- Congenital heart defects research
- Seaweed-derived Bioactive Compounds
- Cardiac, Anesthesia and Surgical Outcomes
- Ecosystem dynamics and resilience
UK Centre for Ecology & Hydrology
2016-2025
University of British Columbia
2023
Bupa Cromwell Hospital
2023
Office of the Medical Examiner of Cook County
2018-2021
Northwestern University
2017-2018
University of Oxford
2012-2016
Great Ormond Street Hospital
2001-2015
University College London
2001-2015
Wellcome Trust
2015
Kenya Medical Research Institute
2015
Summary Dispersal is fundamental to ecological processes at all scales and levels of organization, but progress limited by a lack information about the general shape form plant dispersal kernels. We addressed this gap synthesizing empirical data describing seed fitting kernels representing major types modes. A comprehensive literature search resulted in 107 papers 168 for 144 vascular species. The covered 63 families, continents except Antarctica, broad vegetation forest, grassland,...
BACKGROUND: Following extensive research activity to develop an effective agent control male fertility, such a product may be available for use within ∼5 years. However, little is known concerning contraceptive knowledge, desires and attitudes of men in different countries, their acceptance fertility (MFC). METHODS: A survey >9000 males aged 18–50 years was performed nine countries on four continents 2002. The objective compare, cross-cultural basis, the acceptability MFC among assess...
Mosquito-borne diseases cause substantial mortality and morbidity worldwide. These impacts are widely predicted to increase as temperatures warm extreme precipitation events become more frequent, since mosquito biology disease ecology strongly linked environmental conditions. However, direct evidence linking change changes in mosquito-borne is rare, the ecological mechanisms that may underpin such poorly understood. Environmental drivers, temperature, can have non-linear, opposing on...
Summary Understanding how species' traits relate to their status (e.g. invasiveness or rarity) is important because it can help efficiently focus conservation and management effort infer mechanisms affecting plant status. This particularly for invasiveness, in which proactive action needed restrict the establishment of potentially invasive plants. We tested ability genome size ( DNA 1 C ‐values) explain compared with cytogenetic (chromosome number ploidy level). considered 890 species from...
EFSA was asked to update the 2015 risk assessment on
Summary: Purpose: Multiple, prolonged, generalized, or focal seizures are common in children with severe malaria, without coma. In other contexts, such have been associated the development of epilepsy. The relation between falciparum malaria and epilepsy is undetermined; thus we measured prevalence characteristics a history malaria. Methods: We took detailed from parents 487 (aged 6–9 years) to compare three exposure groups: cerebral (CM), complicated (M/S), those unexposed either...
1. Seed predation of 12 fleshy‐fruited species was recorded in experimental dishes under early successional forest south‐west Germany (four seasons 1992 and 1993) south England (summer 1995). On each occasion, 200 were laid out, containing five seeds a given species. The mean time for three or more to be removed taken as measure granivore preferences. We tested correlations these preferences with several physical nutritional seed traits. 2. Live trapping selectively accessible indicated that...
Summary 1. Climate change impacts on habitat suitability and demography are often studied, but direct effects plant dispersal rarely considered. To address this we analysed climate model projections of future wind speeds modelled their possible spread wind‐dispersed plants. 2. Projections for 17 Global Models three emission scenarios suggested great uncertainty about in southern England by the period 2070–99. ranged from −90% to +100% mean speed, although average projection was large falls...
Nodding syndrome is a devastating neurological disorder of uncertain aetiology affecting children in Africa. There no diagnostic test, and risk factors symptoms that would allow early diagnosis are poorly documented. This study aimed to describe the clinical, electrophysiological brain imaging (MRI) features complications nodding Ugandan children.Case series.22 with brought Mulago National Referral Hospital for assessment.Clinical features, physical functional disabilities, EEG MRI findings...
Summary 1. The development of transgenic technologies, coupled with sterile insect techniques (SIT), is being explored in relation to new approaches for the biological control pests. Recent studies have shown that there are often fitness costs associated strains, but impact these on their potential use pest poorly understood. 2. In this paper, we explore an cost two strategies (classical SIT and late‐acting bisex lethality) using a stage‐structured mathematical model, which parameterized...
Estimating population spread rates across multiple species is vital for projecting biodiversity responses to climate change. A major challenge parameterise models many species. We introduce an approach that addresses this challenge, coupling a trait-based analysis with spatial modelling project 15 000 virtual mammals life histories reflect those seen in the real world. Covariances among life-history traits are estimated from extensive terrestrial mammal data set using Bayesian inference....
Epilepsy is common in sub-Saharan Africa (SSA), but the clinical features and consequences are poorly characterized. Most studies hospital-based, few have compared different ecological sites SSA. We described active convulsive epilepsy (ACE) identified cross-sectional community-based surveys SSA, to understand proximate causes, features, consequences.We performed a detailed neurophysiologic description of ACE cases from community survey 584,586 people using medical history, neurologic...
Xylella fastidiosa is an important plant pathogen that attacks several plants of economic importance. Once restricted to the Americas, bacterium, which causes olive quick decline syndrome, was discovered near Lecce, Italy in 2013. Since initial outbreak, it has invaded 23,000 ha olives Apulian Region, southern Italy, and great concern throughout Mediterranean basin. Therefore, predicting its spread estimating efficacy control are utmost As data on this invasive infectious disease poor, we...
We conducted a community survey to estimate the prevalence and describe features, risk factors, consequences of convulsive status epilepticus (CSE) among people with active epilepsy (ACE) identified in multisite Africa.We obtained clinical histories CSE neurologic examination data 1,196 ACE from population 379,166 3 sites: Agincourt, South Africa; Iganga-Mayuge, Uganda; Kilifi, Kenya. performed serologic assessment for presence antibodies parasitic infections HIV determined adherence...
Abstract Xylella fastidiosa is an important insect‐vectored bacterial plant pathogen with a wide host range, causing significant economic impact in the agricultural and horticultural industries. Once restricted to Americas, severe European outbreaks have been discovered recently Italy, Spain, France, Portugal. The Italian outbreak, detected Puglia 2013, has spread over 100 km, killing millions of olive trees, still expanding. To date, quantified assessment epidemiological parameters useful...
Postmortem genetic testing of young individuals with sudden death has previously identified pathogenic gene variants. However, prior studies primarily considered highly penetrant monogenic variants, often without detailed decedent and family clinical information.To assess genotype phenotype risk in a diverse cohort decedents their families.Pathological whole-genome sequence analysis was conducted referred from national network medical examiners. Cases were accrued prospectively May 2015 to...
Our data suggest that, after a myocardial infarction, integrin-associated protein CD47 on cardiac myocytes is elevated. In culture, increased the surface of dying cardiomyocytes impairs phagocytic removal by immune cell macrophages. After ischemia and reperfusion, acute inhibition with blocking antibodies enhanced dead myocyte clearance phagocytes also improved resolution inflammation, reduced infarct size, preserved contractile function. Early targeting in myocardium reperfusion may be new...
Potentially lethal cardiac channelopathies/cardiomyopathies may underlie a substantial portion of sudden unexplained death in the young (SUDY). The whole-exome molecular autopsy represents latest approach to postmortem genetic testing for SUDY. However, proper variant adjudication setting SUDY can be challenging.From January 2012 through December 2013, 25 consecutive cases from 1 40 years age (average at 27±5.7 years; 13 white, 12 black) Cook County, Illinois, were referred after negative...
Landscape ecological modelling provides a vital means for understanding the interactions between geographical, climatic, and socio-economic drivers of land-use dynamics systems. This growing field is playing an increasing role in informing landscape spatial planning management. Here, we review key approaches that are used modelling. We identify emerging theme increasingly detailed representation process both modelling, with complementary suites ranging from correlative, through aggregated...
It was hypothesized that commuting would elevate blood pressure and lower frustration tolerance. This hypothesis tested by assessing postcommute behavior of 168 paid volunteers in a true experiment whose factors were type commute (drive vs. ride control), direction (North South), gender (male female), choice (salient nonsalient). Multivariate analyses variance indicated subjects who drove 48 km or rode bus the same distance evidenced less tolerance than noncommuting control subjects....