A5073431294- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- Epilepsy research and treatment
- HIV/AIDS Impact and Responses
- Global Maternal and Child Health
- Pharmacological Effects and Toxicity Studies
- Health disparities and outcomes
- Poverty, Education, and Child Welfare
- Blood Pressure and Hypertension Studies
- HIV, Drug Use, Sexual Risk
- Dementia and Cognitive Impairment Research
- Child Nutrition and Water Access
- HIV-related health complications and treatments
- Global Public Health Policies and Epidemiology
- HIV Research and Treatment
- Health, Environment, Cognitive Aging
- Obesity, Physical Activity, Diet
- Global Health Care Issues
- Health Policy Implementation Science
- Intimate Partner and Family Violence
- Sodium Intake and Health
- Neonatal and fetal brain pathology
- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- Hemoglobinopathies and Related Disorders
Agincourt Health and Socio-Demographic Surveillance System
2016-2025
University of the Witwatersrand
2016-2025
South African Medical Research Council
2023-2025
Barrow Neurological Institute
2025
Respiratory and Meningeal Pathogens Research Unit
2023-2024
Umeå University
2013-2023
University of Virginia
2022-2023
National Institute for Communicable Diseases
2023
Mayo Clinic in Arizona
2023
Indepth Network
2013-2022
The Agincourt health and socio-demographic surveillance system (HDSS), located in rural northeast South Africa close to the Mozambique border, was established 1992 support district systems development led by post-apartheid ministry of health. HDSS (90 000 people), based on an annual update resident status vital events, now supports multiple investigations into causes consequences complex health, population social transitions. Observational work includes cohorts focusing different stages...
BackgroundCash transfers have been proposed as an intervention to reduce HIV-infection risk for young women in sub-Saharan Africa. However, scarce evidence is available about their effect on reducing HIV acquisition. We aimed assess the of a conditional cash transfer incidence among rural South Africa.MethodsWe did phase 3, randomised controlled trial (HPTN 068) Bushbuckridge subdistrict Mpumalanga province, included girls aged 13–20 years if they were enrolled school grades 8–11, not...
Cohort Profile : Health and Ageing in Africa: A Longitudinal Study of an INDEPTH Community South Africa (HAALSI)
Africa is experiencing a rapid increase in adult obesity and associated cardiometabolic diseases (CMDs). The H3Africa AWI-Gen Collaborative Centre was established to examine genomic environmental factors that influence body composition, fat distribution CMD risk, with the aim provide insights towards effective treatment intervention strategies. It provides research platform of over 10 500 participants, 40-60 years old, from Burkina Faso, Ghana, Kenya South Africa. Following process involved...
A consequence of the widespread uptake anti-retroviral therapy (ART) is that older South African population will experience an increase in life expectancy, increasing their risk for cardiometabolic diseases (CMD), and its factors. The long-term interactions between HIV infection, treatment, CMD remain to be elucidated population. HAALSI cohort was established investigate impact these on morbidity mortality among middle-aged adults.We recruited randomly selected adults aged 40 or residing...
BackgroundData on influenza community burden and transmission are important to plan interventions especially in resource-limited settings. However, data limited, particularly from low-income middle-income countries. We aimed evaluate the of a rural an urban setting South Africa.MethodsIn this prospective cohort study approximately 50 households were selected sequentially both (Agincourt, Mpumalanga Province, Africa; with health sociodemographic surveillance system) (Klerksdorp, Northwest...
The prevalence of diabetes and hypertension has increased in HIV-positive populations, but there is limited understanding the role that antiretroviral therapy (ART) programs play delivery services for these conditions. aim this study to assess relationship between ART use utilization health care hypertension.Health Aging Africa: A Longitudinal Study an INDEPTH Community South Africa a cohort 5059 adults. baseline collects biomarker-based data on HIV, ART, diabetes, self-reported utilization....
The rapid ageing of populations around the world is accompanied by increasing prevalence multimorbidity. This study one first to present multimorbidity that includes HIV in complex epidemiological setting South Africa, thus filling a gap literature dominated studies high-income or low-HIV settings.Out full sample 5059 people aged 40+, we analysed cross-sectional data on 10 conditions from 3889 enrolled Health and Ageing Africa: A longitudinal an INDEPTH Community Africa (HAALSI) Programme....
BackgroundHIV testing rates in many hyper-endemic areas are lower than needed to curtail the HIV epidemic. New strategies overcome barriers traditional clinic based testing; self-testing is one modality that offers promise reaching individuals who experience clinic-based testing.MethodsWe conducted a randomized control trial among young women ages 18-26 living rural Mpumalanga, South Africa where they were 1:1 allocation either the: (1) Counseling and Testing (HCT) arm: an invitation test at...
Human gut microbiome research focuses on populations living in high-income countries and to a lesser extent, non-urban agriculturalist hunter-gatherer societies. The scarcity of between these extremes limits our understanding how the microbiota relates health disease majority world's population. Here, we evaluate composition transitioning South African using short- long-read sequencing. We analyze stool from adult females rural Bushbuckridge (n = 118) or urban Soweto 51) find that...
Objectives Approximately 80% of people with epilepsy live in low- and middle-income countries (LMICs), where limited resources stigma hinder accurate diagnosis treatment. Clinical machine learning models have demonstrated substantial promise supporting the diagnostic process LMICs by aiding preliminary screening detection possible cases without relying on specialised or trained personnel. How well these generalise to naïve regions is, however, underexplored. Here, we use a novel approach...
Background Epilepsy is common in developing countries, and it often associated with parasitic infections. We investigated the relationship between exposure to infections, particularly multiple infections active convulsive epilepsy (ACE), five sites across sub-Saharan Africa. Methods Findings A case-control design that matched on age location was used. Blood samples were collected from 986 prevalent cases 1,313 age-matched community controls tested for presence of antibodies Onchocerca...
To estimate the association between school attendance, dropout, and risk of incident HIV herpes simplex virus type 2 (HSV-2) infection among young women.
Epilepsy is common in sub-Saharan Africa (SSA), but the clinical features and consequences are poorly characterized. Most studies hospital-based, few have compared different ecological sites SSA. We described active convulsive epilepsy (ACE) identified cross-sectional community-based surveys SSA, to understand proximate causes, features, consequences.We performed a detailed neurophysiologic description of ACE cases from community survey 584,586 people using medical history, neurologic...
To identify the unmet needs for HIV prevention among older adults in rural South Africa.
The uptake of HIV self-testing (HIVST) could address socio-structural barriers that prevent South African youth from utilizing the testing resources available in their communities. However, to facilitate this, we must tailor components HIVST kit and process ensure reach encourage test. purpose this study elucidate concerns issues regarding rollout among youth. This was conducted two phases: 1) focus group discussions with rural, aged 18–24 2) direct observations participants completing an...
We conducted a community survey to estimate the prevalence and describe features, risk factors, consequences of convulsive status epilepticus (CSE) among people with active epilepsy (ACE) identified in multisite Africa.We obtained clinical histories CSE neurologic examination data 1,196 ACE from population 379,166 3 sites: Agincourt, South Africa; Iganga-Mayuge, Uganda; Kilifi, Kenya. performed serologic assessment for presence antibodies parasitic infections HIV determined adherence...