A5016097420- Virus-based gene therapy research
- Forensic and Genetic Research
- Genomics and Phylogenetic Studies
- Molecular Biology Techniques and Applications
- Plant biochemistry and biosynthesis
- Immune Cell Function and Interaction
- Genetic diversity and population structure
- Plant Gene Expression Analysis
- RNA Research and Splicing
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Immunodeficiency and Autoimmune Disorders
- Virology and Viral Diseases
- Plant and animal studies
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Retinal and Optic Conditions
- Plant Diversity and Evolution
- Ocular Infections and Treatments
- RNA Interference and Gene Delivery
- Respiratory viral infections research
- DNA and Nucleic Acid Chemistry
- Immunotherapy and Immune Responses
- RNA modifications and cancer
Jilin Agricultural University
2024-2025
Institute of Botany
2025
Chinese Academy of Sciences
2008-2025
State Key Laboratory of Systematic and Evolutionary Botany
2025
Beijing Botanical Garden
2025
China National Botanical Garden
2025
Shenzhen University
2024
Agricultural Genomics Institute at Shenzhen
2021-2024
Chinese Academy of Agricultural Sciences
2021-2024
Ministry of Agriculture and Rural Affairs
2022-2024
Carnation (Dianthus caryophyllus) is one of the most popular ornamental flowers in world. Although numerous studies on carnations exist, underlying mechanisms flower color, fragrance, and formation double remain unknown. Here, we employed an integrated multi-omics approach to elucidate genetic biochemical pathways important features carnation flowers. First, assembled a high-quality chromosome-scale genome (636 Mb with contig N50 as 14.67 Mb) D. caryophyllus, 'Scarlet Queen'. Next, series...
Abstract The complexity of the tumor microenvironment (TME) is a crucial factor in lung adenocarcinoma (LUAD) progression. To gain deeper insights into molecular mechanisms LUAD, we perform an integrative single-cell RNA sequencing (scRNA-seq) data analysis 377,574 cells from 117 LUAD patient samples. By linking scRNA-seq with bulk gene expression data, identify cluster prognostic-related UPP1 high cells. These cells, primarily situated at invasive front tumors, display stronger association...
Fine particulate matter (PM2.5) has been extensively implicated in the pathogenesis of neurodevelopmental disorders, but underlying mechanism remains unclear. Recent studies have revealed that PM2.5 plays a role regulating iron metabolism and redox homeostasis brain, which is closely associated with ferroptosis. In this study, ferroptosis PM2.5-induced neurotoxicity were investigated mice, primary hippocampal neurons, HT22 cells. Our findings demonstrated exposure to could induce abnormal...
Homosporous lycophytes (Lycopodiaceae) are a deeply diverged lineage in the plant tree of life, having split from heterosporous (
A series of 5-N-methyl quindoline (cryptolepine) derivatives (2a−x) as telomeric quadruplex ligands was synthesized and evaluated. The designed possess a positive charge at the 5-N position aromatic scaffold. binding these compounds evaluated by circular dichroism (CD) spectroscopy, fluorescence resonance energy transfer (FRET) melting assay, polymerase chain reaction (PCR) stop nuclear magnetic (NMR), molecular modeling studies. Introduction not only significantly improved ability but also...
Roses are consistently ranked at the forefront in cut flower production. Increasing demands of market and changing climate conditions have resulted need to further improve diversity quality traits. However, frequent hybridization leads highly heterozygous nature, including allelic variants. Therefore, absence comprehensive genomic information them making it challenging molecular breeding. Here, two haplotype-resolved chromosome genomes for Rosa chinensis 'Chilong Hanzhu' (2n = 14) which is...
Abstract LIN28B is an evolutionarily conserved RNA-binding protein that regulates mRNA translation and miRNA let-7 maturation in embryonic stem cells developing tissues. Increasing evidence demonstrates activated cancer serves as a critical oncogene. However, the underlying molecular mechanisms of function tumorigenesis are still largely unknown. Here we report was expressed over half patients with epithelial ovarian who were examined ( n = 584). Functional experiments demonstrated inhibited...
Mustelidae, as the largest and most-diverse family of order Carnivora, comprises eight subfamilies. Phylogenetic relationships among these Mustelidae subfamilies remain argumentative subjects in recent years. One main reasons is that mustelids represent a typical example rapid evolutionary radiation speciation event. Prior investigation has been concentrated on application different mitochondrial (mt) sequence nuclear protein-coding data, herein we employ 17 non-coding loci (>15 kb),...
Abstract Long non-coding RNA (lncRNA) DANCR has been reported to participate in key processes such as stem cell differentiation and tumorigenesis. In a high throughput screening for lncRNAs involved Doxorubicin-induced apoptosis, we found was suppressed by Doxorubicin it acted an important repressor of apoptosis colorectal cancer. Further studies demonstrated that promoted the oncogenic lncRNA MALAT1 expression via enhancing stability suppress apoptosis. could efficiently mediate suppressive...
Camphor tree [Cinnamomum camphora (L.) J. Presl], a species in the magnoliid family Lauraceae, is known for its rich volatile oils and used as medical cardiotonic scent many perfumed hygiene products. Here, we present high-quality chromosome-scale genome of C. with scaffold N50 64.34 Mb an assembled size 755.41 Mb. Phylogenetic inference revealed that magnoliids are sister group to clade eudicots monocots. Comparative genomic analyses identified two rounds ancient whole-genome duplication...
Massively parallel sequencing (MPS) has rapidly become a promising method for forensic DNA typing, due to its ability detect large number of markers and samples simultaneously in single reaction, sequence information can be obtained directly. In the present study, two kinds genetic markers, short tandem repeat (STR) identity-informative nucleotide polymorphism (iiSNP) were analyzed using ForenSeq Signature Prep Kit, commercially available kit on MPS platform. A total 152 including 27...
Abstract Compared with most flowers where the showy part comprises specialized leaves (petals) directly subtending reproductive structures, Zingiberaceae species produce “flowers” through modifications of (bracts) true throughout an inflorescence. Curcuma alismatifolia , belonging to family, a plant originating from Southeast Asia, has become increasingly popular in flower market worldwide because its varied and esthetically pleasing bracts produced different cultivars. Here, we present...
Guizhou province in southwest China has abundant genetic and cultural diversities, but the forensic features structure of populations remain poorly understood due to sparse sampling present-day populations. Here, we present 30 insertion/deletion polymorphisms (InDels) data 591 human individuals collected from four populations, Dong, Yi, Han, Chuanqing residing Guizhou. We calculated parameters InDel loci found that this panel meets efficiency personal identification based on high combined...