A5100334217- Global Maternal and Child Health
- Reproductive System and Pregnancy
- Erythrocyte Function and Pathophysiology
- Reproductive Biology and Fertility
- Folklore, Mythology, and Literature Studies
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Themes in Literature Analysis
- Pancreatic function and diabetes
- Reproductive tract infections research
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Birth, Development, and Health
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- interferon and immune responses
- Heme Oxygenase-1 and Carbon Monoxide
- Prenatal Screening and Diagnostics
- Cancer Risks and Factors
- Nitric Oxide and Endothelin Effects
- Cardiovascular Effects of Exercise
- Neuroscience of respiration and sleep
- Blood properties and coagulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Hypothalamic control of reproductive hormones
Sun Yat-sen University
2008-2025
Sun Yat-sen Memorial Hospital
2014-2025
National Clinical Research Center for Digestive Diseases
2025
Zhongshan People's Hospital
2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Heidelberg University
2024
University Hospital Heidelberg
2024
Zhongshan Hospital
2023
Fudan University
2023
The First Affiliated Hospital, Sun Yat-sen University
2023
The association between early glycated hemoglobin (HbA1c) and the risk of neonatal respiratory distress syndrome (NRDS) with preterm premature rupture membranes (PPROM) population remains largely unknown. impact diabetes mellitus (DM) on NRDS is also controversial. HbA1c was assessed in late pregnancy. Multivariate logistic regression restricted cubic spline (RCS) analyses were performed to evaluate incidence non-DM group. Propensity score matching (PSM) balance baseline characteristics DM...
Arrhythmogenic cardiomyopathy (ACM), a fatal heart disease characterized by fibroadipocytic replacement of cardiac myocytes, accounts for 20% sudden death and lacks effective treatment. It is often caused mutations in desmosome proteins, with Desmoglein-2 (DSG2) as common etiology. However, the mechanism underlying accumulation fibrofatty ACM remains unknown, which impedes development curative Here we investigated fat mouse model induced cardiac-specific knockout Dsg2 (CS-Dsg2−/−). Heart...
Abstract Pathological ocular angiogenesis is a significant cause of irreversible vision loss and blindness worldwide. Currently, most studies have focused on the factors in vascular diseases, very few endogenous anti‐angiogenic compounds been found. Moreover, although inflammation closely related to predominant processes involved angiogenesis, mechanisms by which regulates pathological remain obscure. In this study, endothelial cells (VECs)‐specific factor identified, apoptosis...
Background Unexplained recurrent spontaneous abortion is a serious reproductive problem of unknown etiology. Thyroid peroxidase antibodies (TPO-Ab) may be associated with pregnancy outcomes in unexplained normal thyroid function. Objective This study aimed to investigate the relationship between TPO-Ab and first trimester miscarriage rate/live birth rate women Methods We retrospectively analyzed clinical data 297 who met our strict inclusion criteria, comparing positive negative groups. For...
Purpose To investigate the expression of Glucagon-like peptide-1 receptor (GLP-1R), sodium-glucose co-transporter (SGLT) 1, SGLT2, Glucose transporter type 1 (GLUT1) and GLUT2 in patients with diabetic retinopathy (DR). Methods We obtained peripheral blood mononuclear cells (PBMCs) vitreous samples from 26 proliferative DR (PDR) patients, 25 non-proliferative (NPDR) non-DR (NDR) nondiabetic idiopathic epiretinal membranes (ERMs, control). The protein level mRNA GLP-1R were quantified by...
Background: Female Genital Tract (FGT) is an important micro-ecological area of human body. Microbiota in the lower reproductive tract may subsequently invade uterine cavity during embryo implantation and produce immune responses. CBA/J×DBA/2 mating combination has been widely used as abortion-prone mice model but whether microbiota existed their remains unclear. In this context, role microbial communities response deserves attention. Objective: To investigate relationship between...
Objective: Despite a growing association between inflammation and preterm labor, the underlying mechanisms explaining development of labor after infection are still poorly understood. Here, we use RNA-sequencing to characterize transcriptome changes placenta tissue in mouse model.Materials methods: On day 15.5 gestation, BALB/c mice received intrauterine injection LPS mimic labor. A comprehensive catalog genes was obtained using RNA-sequences followed by bioinformatics analysis. The NOD-like...
Abstract Glucagon-like peptide 1 (GLP-1) is a gut-derived hormone secreted by intestinal L cells and vital for postprandial glycemic control. As open-type enteroendocrine cells, whether can sense mechanical stimuli caused chyme thus regulate GLP-1 synthesis secretion unexplored. Our study showed expression of Piezo1 in cells. Its level varied different energy status correlates with blood glucose levels. Mice cell-specific loss ( IntL-Piezo1 -/- ) exhibited impaired tolerance, increased body...
<title>Abstract</title> Triage is of great importance in the procedure emergency diagnosis, which needs artificial intelligence to assist due scarcity medical resources. However, AI models for aiding triage have difficulty identifying levels that are difficult or ambiguous human clinicians distinguish. Here, address this challenge and improve performance models, we propose KUTS, a foundational classification model triage, leverages knowledge prompt-tuning encoder an uncertainty-based...
Abstract Whole‐exome sequencing (WES) is frequently utilized in diagnosing reproductive genetic disorders to identify various variants. Canonical ±1,2 splice sites are typically considered highly pathogenic, while variants at the 5′ or 3′ ends of exon boundaries often synonymous missense variants, with their potential impact on abnormal gene splicing overlooked. In this study, we identified five located last two bases exons and canonical distinct families affected by through WES. Minigene...
Background: Previous studies have shown that the presence of dyslipidemia can increase risk developing GDM (gestational diabetes mellitus). However, this was not yet explored in women undergoing ART (artificial reproductive technologies), which is a group especially at for GDM. Our aim is, therefore, to analyze whether there an association between pre-pregnancy lipid parameters and if so, parameter associated strongest.
Abstract Objectives In this study, we aimed to investigate the vascular response an intravascular lithotripsy (IVL) shockwave balloon in a healthy porcine coronary artery model. Background IVL is novel clinical technique for modifying heavily calcified atherosclerotic plaques. Methods A total of 24 arteries were treated with or plain old angioplasty (POBA). Histology, histomorphometry, quantitative angiography analysis (QCA), and optical coherence tomography (OCT) performed post-procedure at...
INTRODUCTION Abortion-related complications are one of the five main causes maternal mortality. However, research about abortion is very limited in fragile and conflict-affected settings. We aimed to describe severity abortion-related contributing factors two MSF-supported referral hospitals; a rural setting, northern Nigeria, capital city, Bangui, Central African Republic (CAR). METHODS This cross-sectional mixed-methods study included four components: 1) clinical using prospective review...