A5100390067- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Immunotherapy and Immune Responses
- Ectopic Pregnancy Diagnosis and Management
- T-cell and B-cell Immunology
- Maternal and Perinatal Health Interventions
- Birth, Development, and Health
- Reproductive tract infections research
- Endometriosis Research and Treatment
- Pregnancy-related medical research
- Prenatal Screening and Diagnostics
- Immune cells in cancer
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Galectins and Cancer Biology
- Maternal and fetal healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- RNA Research and Splicing
- Blood Coagulation and Thrombosis Mechanisms
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Impact on Reproduction
Sun Yat-sen University
2013-2024
Sun Yat-sen Memorial Hospital
2013-2024
First Hospital of Lanzhou University
2022-2024
Lanzhou University
2022-2024
Fudan University Shanghai Cancer Center
2020-2024
Jiaxing University
2022-2023
Yale University
2022-2023
University of Science and Technology of China
2020
Hainan Medical University
2018
Zunyi Medical University
2016
The aim of this study was to evaluate the effectiveness and safety emergency cervical cerclage in women with advanced dilatation bulging fetal membranes. included 158 who underwent because cervix protruding membranes mid-trimester at Sun Yat-sen Memorial Hospital University. Pregnancy outcomes pregnancy outcome related clinical features were analyzed retrospectively. Analysis revealed that placement led delivery live infants a success rate 82.28%. mean interval between 52.16.±26.62 days,...
To determine the expression profiles of circular RNAs (circRNAs) women with severe pre-eclampsia (sPE group) versus normal pregnancies (normal control group). RNA-sequencing (RNA-seq) was conducted to characterize differentially expressed circRNAs and mRNAs in placental tissues sPE pregnancies. circRNA functions were predicted by Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) database analysis. The backsplicing junctions validated use divergent primers. Relative levels cirRNAs...
Tumor-associated macrophages (TAMs) were a major component of tumor, which comprised up to 50% tumor mass, and correlated with poor prognosis in more than 80% cases. TAMs resistant radiotherapy chemotherapy, radiation could further activate promote progression. Herein, we explored kind Bi-based mesoporous upconversion nanophosphor (UCNP) loaded doxorubicin (UCNP-DOX) elicit immunogenic cell death repolarize an antitumor M1-like type for strengthening the tumor-specific immune effects X-ray...
The placental hormone leptin has important functions in fetal and neonatal growth, prevents depressed respiration leptin-deficient mice. effect of on respiratory distress suffered by low birth weight premature infants been studied. However, it is unclear how enhances lung maturity the fetus ameliorates distress. In present study, we found that antenatal treatment with for 2 d significantly enhanced relative alveolus area improved lungs a rat model growth restriction (FGR). Mean wet were...
As immune regulatory and effector cells, monocytes play an important role in the blood-extracorporeal circuit contact-related acute lung injury patients undergoing cardiopulmonary bypass (CPB). However, circulating are phenotypically functionally heterogeneous, so we characterised how immature affect induced by CPB.The identification dynamic changes monocyte subsets were monitored flow cytometry CPB a rat model of CPB. The differentiation migration explored vitro cultures adoptive transfer...
T cell quiescence is essential for maintaining a broad repertoire against large pool of diverse antigens from microbes and tumors, but the underlying molecular mechanisms remain largely unknown. We show here that CD8α critical maintenance CD8 + cells in physiologically quiescent state peripheral lymphoid organs. Upon inducible deletion CD8α, both naïve memory spontaneously acquired activation phenotypes subsequently died without exposure to specific antigens. PILRα was identified as ligand...
Acute myeloid leukemia (AML) presents a pressing medical need in that it is largely resistant to standard chemotherapy as well modern therapeutics such targeted therapy and immunotherapy, including anti-PD therapy. We demonstrate Programmed Death-1 Homolog (PD-1H), an immune co-inhibitory molecule highly expressed blasts from the bone marrow of AML patients, while normal cell subsets T cells have expression PD-1H. In studies employing syngeneic humanized mouse models, overexpression PD-1H...
Interleukin-21 (IL-21) exerts critical functions in T helper type 17 (Th17) cell development. However, the effect of IL-21 on differentiation IL-22-producing cells is not clear. Here we showed that induced human naive CD8(+) into Tc22 without expression IL-17. The addition transforming growth factor-β inhibited production IL-22 but Both IL-15 and IL-2 interferon-γ did induce Tc22, which suggests common γ-chain signals are specific to promote synthesis. produce greater amounts than memory...
Abstract Impaired T lymphopoiesis is associated with immunosuppression of the adaptive immune response and plays a role in morbidity mortality patients animal models sepsis. Although previous studies examined several intrathymic mechanisms that negatively affect lymphopoiesis, extrathymic remain poorly understood. Here, we report dramatic decrease percentage early lineage progenitors (ETPs) three sepsis mice (cecal ligation puncture, lipopolysaccharide continuous injection, poly I:C...
Abstract Background Skin cutaneous melanoma (SKCM) is an extremely malignant tumor that associated with a poor prognosis. LSM2 has been found to be related different types of tumors; however, its role in SKCM poorly defined. We aimed determine the value as prognostic biomarker for SKCM. Methods The expression profile mRNA was compared between and normal tissues public databases, such TCGA, GEO, BioGPS. protein explored using immunohistochemistry (IHC) on tissue microarray containing 44 8...
Abstract Aim The aim of this study was to observe insulin resistance and β‐cell function changes among women diagnosed with gestational impaired glucose tolerance or diabetes mellitus ( GDM ) in mid‐pregnancy. Material Methods Sixty‐four pregnant receiving prenatal care underwent an oral test at 20–24 weeks gestation release test. group included 34 , the subjects normal blood were control group. Insulin islet observed Results homeostatic model assessment‐β levels late pregnancy higher than...
Background Unexplained recurrent spontaneous abortion is a serious reproductive problem of unknown etiology. Thyroid peroxidase antibodies (TPO-Ab) may be associated with pregnancy outcomes in unexplained normal thyroid function. Objective This study aimed to investigate the relationship between TPO-Ab and first trimester miscarriage rate/live birth rate women Methods We retrospectively analyzed clinical data 297 who met our strict inclusion criteria, comparing positive negative groups. For...
We sought to explore the functions and modulated factors of NOD1 in normal decidual stromal cells (DSCs) derived from first trimester pregnancy whether existed different expression between unexplained recurrent loss (URPL) DSCs. Twenty-six patients with pregnancies that required abortion 12 URPL at were enrolled for study. As a result, we found lower levels DSCs compared those early pregnancy. Furthermore, increased induced apoptosis monocyte chemotactic protein-1 (MCP-1) IL-1β (interleukin...
BACKGROUND Dinoprostone is the recommended primary option for induction of labor (IOL) in late-term pregnancies (LTPs). However, oxytocin used developing and rural areas, studies have supported similar effectiveness dinoprostone reducing rate cesarean delivery LTPs with a Bishop's score between 4-6. This study aimed to compare IOL section ten centers South China. MATERIAL AND METHODS A retrospective included 1,408 women LTP, subgroups including 0-3 Rates were compared given vaginal...
Abstract Background The like-Smith (LSM) family is a group of RNA-binding proteins involved in RNA metabolism. However, their involvement tumors, particularly skin cutaneous melanoma (SKCM), not fully understood. In this study, we focused on the expression profiles and prognostic values LSM SKCM. Methods Raw data were downloaded from Cancer Genome Atlas. profile value genes SKCM explored using GEPIA, cBioPortal, HPA databases. Protein–protein gene–gene interaction analyses performed STRING...