A5016033672- Selenium in Biological Systems
- Trace Elements in Health
- Bone Metabolism and Diseases
- Pregnancy and Medication Impact
- Spondyloarthritis Studies and Treatments
- MicroRNA in disease regulation
- Gout, Hyperuricemia, Uric Acid
- Aquaculture Nutrition and Growth
- Osteoarthritis Treatment and Mechanisms
- Bone health and osteoporosis research
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Glutathione Transferases and Polymorphisms
- Aquaculture disease management and microbiota
- Extracellular vesicles in disease
- Bone health and treatments
- Plasma Applications and Diagnostics
- Phytochemical compounds biological activities
- Mycotoxins in Agriculture and Food
- Phytochemistry and Bioactivity Studies
- Cleft Lip and Palate Research
- Wnt/β-catenin signaling in development and cancer
- Genetic Associations and Epidemiology
- Heavy Metal Exposure and Toxicity
- Autophagy in Disease and Therapy
Xi'an Jiaotong University
2016-2025
Huazhong University of Science and Technology
2008-2025
Second Affiliated Hospital of Jilin University
2025
East China Normal University
2025
Xi'an Honghui Hospital
2021-2024
National Health and Family Planning Commission
2015-2024
Nanjing Agricultural University
2014-2024
University of British Columbia
2024
Sichuan Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Chondrocytes are the key target cells of cartilage degeneration that occurs in Kashin-Beck disease (KBD) and osteoarthritis (OA). However, heterogeneity articular cell types present KBD OA patients healthy controls is still unknown, which has prevented study pathophysiology mechanisms underlying roles different populations chondrocytes processes leading to OA. Here, we aimed identify transcriptional programmes all major with KBD, markers discriminate among these three groups. Single-cell RNA...
Abstract The chemical characteristics of atmospheric pressure dielectric barrier discharge plasma generated in air are very sensitive to some factors, such as environment temperature and power. There two typical modes, namely the ozone mode nitrogen oxides mode. In this paper, surface micro-discharge respectively at temperatures 5 °C 50 when power is almost kept 6 W, plasma-activated water (PAW) prepared by means passing exhaust gases into deionized water. By comparing reactive species PAW...
The relationship between T-2 toxin and deoxynivalenol (DON) the risk of Kashin-Beck disease is still controversial since it poorly known about their selectivity in cartilage damage. We aimed to compare cytotoxicity DON on cell lines representative types encountered vivo, including human chondrocytes (C28/I2), hepatic epithelial cells (L-02) tubular (HK-2). In addition, we determined distribution Sprague-Dawley (SD) rats after a single dose exposure. or decreased proliferation time-...
Endoplasmic reticulum (ER)-mitochondria contact sites (ERMCSs) are crucial for multiple cellular processes such as calcium signaling, lipid transport, and mitochondrial dynamics. However, the molecular organization, functions, regulation of ERMCS, physiological roles altered ERMCSs not fully understood in higher eukaryotes. We found that Miga, a mitochondrion located protein, markedly increases causes severe neurodegeneration upon overexpression fly eyes. Miga interacts with an ER protein...
Abstract The first-passage time probability plays an important role in the reliability assessment of dynamic systems random vibrations. To find solution is a challenging task. analytical to this problem not available even for linear systems. For nonlinear and multi-degree-of-freedom systems, it more challenging. This paper proposes radial basis function neural networks method solving linear, nonlinear, In paper, proposed applied solve backward Kolmogorov equation subject boundary conditions...
Abstract Background Osteoarthritis (OA) and Kashin-Beck disease (KBD) both are two severe osteochondral disorders. In this study, we aimed to compare the gut microbiota structure between OA KBD patients. Methods Fecal samples collected from patients were used characterize using 16S rDNA gene sequencing. To identify whether microbial changes at species level associated with genes or functions of bacteria groups, metagenomic sequencing fecal subjects was performed. Results The group...
Abstract Converging lines of evidence suggest that lanthanum tends to deposit in bone. The influence ion (La 3+ ) on osteoblast differentiation and the related mechanism are essential understanding its effect bone metabolism. In this study, La treatment enhanced vitro as evidenced by promoting alkaline phosphatase (ALP) activity, osteocalcin (OC) secretion, matrix mineralization. expressions osteoblast‐specific genes Cbfa‐1, osteopontin (OPN), sialoprotein (BSP) were all increased presence ,...
In this report, we have investigated the apoptosis and autophagy of chondrocytes induced by T-2 HT-2 toxins. The viability was measured MTT assay. Malondialdehyde (MDA) superoxide dismutase (SOD) kits were used to measure oxidative stress chondrocytes. using flow cytometry. Hoechst 33258 MDC staining agents introduced analyze induction in chondrocytes, respectively. Protein expression Bax, caspase-9, caspase-3, Beclin1 examined western blotting analysis. toxins significantly decreased a...
Kashin-Beck disease (KBD) is a severe osteochondral disorder that may be driven by the interaction between genetic and environmental factors. We aimed to improve our understanding of gut microbiota structure in KBD patients different grades relationship serum metabolites. Fecal samples collected from normal controls (NCs) were used characterize using 16S rDNA gene metabolomic sequencing via liquid chromatography-mass spectrometry (LC/MS). To identify whether microbial changes at species...
Selenium deficiency is a primary risk factor of Kashin-Beck disease (KBD). This study aimed to investigate whether children in endemic areas could maintain sufficient selenium intake after termination supplement administration, and evaluate their comprehensive nutritional status dietary structure. Duplicate portion sampling combined with questionnaire was adopted collect data on categories quantity all food ingested three consecutive days. Occipital hair also collected detect content by...
Abstract Osteoporosis is a common bone disease characterized by loss of mass, reduced strength, and deterioration microstructure. ROS-induced oxidative stress plays an important role in osteoporosis. However, the biomarkers molecular mechanisms are still unclear. We obtained datasets from Gene Expression Omnibus (GEO) database, performed differential analysis, Venn weighted correlation network analysis (WGCNA) out hub genes. Then, between inflammatory factors genes was analyzed, Mendelian...
The poultry skeletal system serves multiple functions, not only providing structural integrity but also maintaining the balance of essential minerals such as calcium and phosphorus. However, in recent years, consideration traits has been overlooked selective breeding broilers, resulting an inadequate adaptation to cope with rapid increase body weight. Consequently, this leads lameness bone diseases tibial dyschondroplasia (TD), which significantly impact production performance broilers....
Cigarette smoke exposure is a major cause of chronic obstructive pulmonary disease (COPD), but the underlying molecular inflammatory mechanisms remain poorly understood. Previous studies have found that disrupts cell-cell adhesion by inducing epithelial barrier damage to adherens junction proteins, primarily E-cadherin (E-cad) and p120-catenin (p120). Recently, anti-inflammatory role p120 has drawn increasing attention. In this study, we demonstrate in cigarette extract-induced response,...