A5007808322- Bone health and osteoporosis research
- Bone health and treatments
- Oral microbiology and periodontitis research
- Hip and Femur Fractures
- Dental Health and Care Utilization
- Bone and Joint Diseases
- Reproductive Health and Contraception
- Menopause: Health Impacts and Treatments
- Economic and Financial Impacts of Cancer
- Cancer Risks and Factors
- Medical Coding and Health Information
- Oral Health Pathology and Treatment
- Orthopaedic implants and arthroplasty
- Nutrition and Health in Aging
- Menstrual Health and Disorders
- Vitamin D Research Studies
- Primary Care and Health Outcomes
- Nutritional Studies and Diet
- Bone fractures and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Medication Adherence and Compliance
- Reliability and Agreement in Measurement
- Pharmacological Effects and Toxicity Studies
- Advanced Causal Inference Techniques
- Phytoestrogen effects and research
Amgen (United States)
2014-2024
St. Joseph’s Healthcare Hamilton
2017
McMaster University
2017
Geriatric Research Education and Clinical Center
2017
Outcomes Research Consortium
2017
Group Health Cooperative
2006-2016
University of Washington
2001-2016
Institute on Aging
2016
National Institute on Aging
2016
University of California, San Diego
2016
Genetic studies require precise phenotype definitions, but electronic medical record (EMR) data are recorded inconsistently and in a variety of formats.To present lessons learned about validation EMR-based phenotypes from the Electronic Medical Records Genomics (eMERGE) studies.The eMERGE network created validated 13 EMR-derived algorithms. Network sites Group Health, Marshfield Clinic, Mayo Northwestern University, Vanderbilt University.By validating we that: (1) multisite improves...
No consensus exists about when researchers need additional participant consent (reconsent) to submit existing data the federal database of Genotypes and Phenotypes (dbGaP). Re-consent for submission their dbGaP was sought from 1,340 study participants, 1,159 (86%) whom agreed. We invited first 400 those who agreed complete a telephone survey reasoning decision satisfaction with reconsent process; 365 participants completed survey. Respondents reported that it very (69%) or somewhat (21%)...
Abstract Although clinical trials have shown that denosumab significantly increases bone mineral density at key skeletal sites more than oral bisphosphonates, evidence is lacking from head-to-head randomized evaluating fracture outcomes. This retrospective cohort study uses administrative claims data Medicare fee-for service beneficiaries to evaluate the comparative effectiveness of vs alendronate in reducing risk among women with PMO US. Women ≥ 66 yr age no prior history osteoporosis...
While observational studies have suggested that vitamin D deficiency increases risk of depression, few clinical trials tested whether supplementation affects the occurrence depression symptoms. The authors evaluated impact daily with 400 IU D3 combined 1,000 mg elemental calcium on measures in a randomized, double-blinded US trial comprising 36,282 postmenopausal women. Burnam scale and current use antidepressant medication were used to assess depressive symptoms at randomization...
Oral contraceptive (OC) use is common, but bone changes associated with of contemporary OC remain unclear.The objective the study was to compare mineral density (BMD) change in adolescent and young adult users discontinuers two estrogen doses, relative nonusers.This a prospective cohort study, Group Health Cooperative.Participants included 606 women aged 14-30 yr (50% adolescents 14-18 yr): 389 [62% 30-35 μg ethinyl estradiol (EE)] 217 age-similar nonusers; there were 172 discontinuers. The...
BACKGROUND: Prior research has shown that rates of persistence and compliance with osteoporosis therapies are associated significantly fewer vertebral, nonvertebral, hip fractures. A number studies have examined medication-taking behavior oral bisphosphonates teriparatide, these 1-year ranged from 39.9% to 56.7%. Limited real-world data available regarding newer such as denosumab, a RANK ligand inhibitor administered every 6 months subcutaneous injection. OBJECTIVE: To assess over 1 year...
About one-third of adults with diabetes have severe oral complications. However, limited previous research has investigated dental care utilization associated diabetes. This project had two purposes: to develop a methodology estimate using claims data and use this compare between without diabetes.Data included secondary enrollment demographic from Washington Dental Service (WDS) Group Health Cooperative (GH), clinical GH, dental-utilization WDS during 2002-2006. medical records GH were...
Objective. Previous studies combining biologic disease-modifying antirheumatic drugs (bDMARD) to treat rheumatoid arthritis (RA) have shown an increased risk of infection. However, the infection with concurrent use denosumab, a agent for treatment osteoporosis, and bDMARD remains unclear. Here, we evaluated incidence serious opportunistic infections in patients treated concurrently denosumab alone. Methods. A chart review RA from 2 Canadian rheumatology practices between July 1, 2010, 31,...
OBJECTIVE Compare GHb among people with diabetes who have and not received periodontal care. RESEARCH DESIGN AND METHODS This cross-sectional study linked 5 years of electronic medical record dental insurance data for dually insured patients diabetes, ages 40–70 (n = 5,103). We assessed the association between annual mean (%) care (a proxy periodontitis) defined using claim codes. Among care, we treatment intensity. determined associations linear regression adjusted potential confounders...
Abstract Purpose In contrast to randomized clinical trials, comparative safety and effectiveness assessments of osteoporosis medications in practice may be subject confounding by indication. We used negative control outcomes detect residual when comparing medications. Methods Using MarketScan Commercial Supplemental claims, we identified women aged ≥55 years who initiated an oral bisphosphonate (BP) (risedronate, alendronate, or ibandronate), denosumab (an injected biologic), intravenous...
Background: Our objectives were to describe the prevalence of periodontal care (a marker periodontitis) among persons with and without diabetes examine association between diabetes. Methods: We conducted a cross‐sectional analysis, using 5 years electronic data from population‐based cohort (N = 46,132), aged 40 70 years, dental medical insurance, ≥1 visit. Periodontal (yes/no) was defined by claims codes for procedures used manage periodontitis. The determined logistic regression adjusted...
Background: Understanding adherence to bone mineral density (BMD) screening after breast cancer (BC) treatment with aromatase inhibitors (AI) is an important first step in preventing or treating BC-related osteoporosis. Methods: This retrospective cohort study assessed receipt and BMD among 342 women diagnosed BC who were at high risk for osteoporosis AI between 2004 2007. Nonadherence baseline annual (recommended by 2003 American Society of Clinical Oncology Guidelines) was using...
Abstract The availability of automated administrative databases in medical and dental healthcare, combined with modern computing power, allows sophisticated multi‐layered analyses the causes consequences care delivered to large populations. These are now also commonly linked data extracted from electronic records, used measure health system performance, adjust payments, assess providers for quality improvement purposes, inform policy decisions. Use insurance can be particularly powerful when...
The effect of oral contraceptive (OC) use on risk fracture remains unclear, and during later reproductive life may be increasing. To determine the association between OC across menopausal transition, we conducted a population-based case-control study in Pacific Northwest HMO, Group Health Cooperative.