A5087063355- Advanced Radiotherapy Techniques
- Endometrial and Cervical Cancer Treatments
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Atomic and Subatomic Physics Research
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Advanced NMR Techniques and Applications
- Management of metastatic bone disease
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Analysis
- Prostate Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Head and Neck Cancer Studies
- Cancer Risks and Factors
- Nuclear Physics and Applications
- Digital Radiography and Breast Imaging
- Advances in Oncology and Radiotherapy
- Advanced X-ray Imaging Techniques
- Prenatal Screening and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Ultrasound and Hyperthermia Applications
The University of Texas Southwestern Medical Center
2017-2024
Southwestern Medical Center
2017-2023
Radiation Oncology Associates
2018
University of Michigan
2014-2017
Sunnybrook Health Science Centre
2015-2017
Health Sciences Centre
2015-2017
University of Toronto
2009-2017
Sunnybrook Hospital
2016
Sunnybrook Research Institute
2016
Ann Arbor VA Medical Center
2015
To quantitatively compare hyperpolarized helium 3 (3He) and xenon 129 (129Xe) magnetic resonance (MR) images obtained within 5 minutes in healthy volunteers patients with chronic obstructive pulmonary disease (COPD) to evaluate the correlations between 3He 129Xe MR imaging measurements those from spirometry plethysmography.This study was approved by an ethics board compliant HIPAA. Written informed consent all subjects. Eight 10 COPD underwent imaging, spirometry, plethysmography....
Accurate segmentation of prostate and surrounding organs at risk is important for cancer radiotherapy treatment planning. We present a fully automated workflow male pelvic CT image using deep learning. The architecture consists 2D organ volume localization network followed by 3D volumetric prostate, bladder, rectum, femoral heads. used multi-channel U-Net with encoding arm modified aggregated residual networks, known as ResNeXt. models were trained tested on dataset comprising 136 patients....
Inter-and intra-observer variation in delineating regions of interest (ROIs) occurs because differences expertise level and preferences the radiation oncologists. We evaluated accuracy a segmentation model using U-Net structure to delineate prostate, bladder, rectum male pelvic CT images. The dataset used for training testing consisted raw scan images 85 prostate cancer patients. designed 2D directly learn mapping function that converts grayscale image its corresponding OAR segmented image....
In subjects with chronic obstructive pulmonary disease (COPD), hyperpolarized xenon-129 ((129)Xe) magnetic resonance imaging (MRI) reveals significantly greater ventilation defects than helium-3 ((3)He) MRI. The physiological and/or morphological determinants of and the differences observed between (3)He (129)Xe MRI are not yet understood. Here we aimed to determine structural basis for in COPD using apparent diffusion coefficients (ADC) computed tomography (CT). Ten ex-smokers provided...
<h3>Background</h3> The functional effects of abnormal diffusing capacity for carbon monoxide (DL<sub>CO</sub>) in ex-smokers without chronic obstructive pulmonary disease (COPD) are not well understood. <h3>Objective</h3> We aimed to evaluate and compare established clinical, physiological emerging imaging measurements with normal spirometry DL<sub>CO</sub> a group Global Initiative Chronic Obstructive Lung Disease (GOLD) stage I COPD. <h3>Methods</h3> enrolled 38 15 subjects COPD who...
Abstract Purpose The purpose of this study was to address the dosimetric accuracy synthetic computed tomography (sCT) images patients with brain tumor generated using a modified generative adversarial network (GAN) method, for their use in magnetic resonance imaging (MRI)‐only treatment planning proton therapy. Methods Dose volume histogram (DVH) analysis performed on CT and sCT plans intensity‐modulated therapy (IMPT). All were robustly optimized commercially available system (RayStation,...
Noble gas pulmonary magnetic resonance imaging (MRI) is transitioning away from 3He to 129Xe gas, but the physiological/clinical relevance of apparent diffusion coefficient (ADC) parenchyma measurements not well understood. Therefore, our objective was generate MRI ADC for comparison with and well-established alveolar structure function in older never-smokers ex-smokers chronic obstructive disease (COPD). In four 10 COPD ex-smokers, (b = 1.6 sec/cm2) 12, 20, 30 ADC, computed tomography (CT)...
Purpose To evaluate plan quality of a novel MRI‐compatible direction modulated brachytherapy (DMBT) tandem applicator using 192 Ir, 60 Co, and 169 Yb HDR sources, for various cervical cancer high‐risk clinical target volumes (CTV HR ). Materials Methods The DMBT has six peripheral grooves 1.3‐mm diameter along 5.4‐mm thick nonmagnetic tungsten alloy rod. Monte Carlo (MC) simulations were used to benchmark the dosimetric parameters sources in water phantom against literature data. 45 cases...
Background and purpose.Replacing CT imaging with MR for MR-only radiotherapy has sparked the interest of many scientists is being increasingly adopted in radiation oncology. Although studies have focused on generating images from images, only models data same dataset were tested. Therefore, how well trained model will work different hospitals protocols still unknown. In this study, we addressed generalization problem MR-to-CT conversion task.Materials methods.Brain T2 corresponding collected...
Purpose: Effective target definition and broad employment of treatment response assessment with dynamic contrast‐enhanced CT in radiation oncology requires increased speed coverage for use within a single bolus injection. To this end, novel volumetric scanner (Aquilion One, Toshiba, Tochigi Pref., Japan) has been installed at the Princess Margaret Hospital implementation into routine simulation. This technology offers great advantages anatomical functional imaging both scan coverage. The aim...
This study evaluated the dosimetric impact of surface dose reduction due to loss backscatter from bone interface in kilovoltage (kV) X‐ray radiation therapy. Monte Carlo simulation was carried out using EGSnrc code. An inhomogeneous phantom containing a thin water layer (0.5–5 mm) on top irradiated by clinical 105 kVp photon beam produced Gulmay D3225 machine. Field sizes 2, 5, and 10 cm diameter source‐to‐surface distance 20 were used. Surface doses for different configurations calculated...
Purpose: To develop a comprehensive peripheral dose (PD) dataset for the two unflattened beams of nominal energy 6 and 10 MV use in clinical care. Methods: Measurements were made 40 × 120 20 cm3 (width length depth) stack solid water using an ionization chamber at varying depths (dmax, 5, cm), field sizes (3 3 to 30 cm2), distances from edge (5–40 cm). The effects multileaf collimator (MLC) rotation also evaluated cm2 field. Using same phantom geometry, accuracy analytic anisotropic...
To create a comprehensive dataset of peripheral dose (PD) measurements from new generation linear accelerators with and without the presence newly designed fetal shield, PD were performed to evaluate effects depth, field size, distance edge, collimator angle, beam modifiers for common treatment protocols modalities. A custom lead shield was made our department that allows external treatments multiple angles while minimizing need adjust during patient treatments. acquired series static fields...
Purpose: Manual segmentation of lung tumors is observer dependent and time-consuming but an important component radiology radiation oncology workflow. The objective this study was to generate automated tumor measurement tool for pulmonary metastatic from x-ray computed tomography (CT) images improve reproducibility decrease the time required segment boundaries. Methods: authors developed algorithm volumetric image analysis chest CT using shape constrained Otsu multithresholding (SCOMT)...