A5082442758- Head and Neck Cancer Studies
- Bone and Joint Diseases
- Salivary Gland Disorders and Functions
- Cardiac Arrest and Resuscitation
- Salivary Gland Tumors Diagnosis and Treatment
- Bone health and treatments
- Cancer Cells and Metastasis
- AI in cancer detection
- Cell Adhesion Molecules Research
- Proteoglycans and glycosaminoglycans research
- Digital Radiography and Breast Imaging
- Global Cancer Incidence and Screening
- Disaster Response and Management
- Oral Health Pathology and Treatment
- Rheumatoid Arthritis Research and Therapies
- Cancer, Hypoxia, and Metabolism
- Bone Tumor Diagnosis and Treatments
- Lung Cancer Treatments and Mutations
- Mesenchymal stem cell research
- Ear and Head Tumors
- Trauma and Emergency Care Studies
- Cancer Immunotherapy and Biomarkers
- Systemic Lupus Erythematosus Research
- Respiratory Support and Mechanisms
- Photodynamic Therapy Research Studies
Nippon Sport Science University
2021-2025
Japan Cancer Society
2023-2025
Duke-NUS Medical School
2025
Nippon Dental University
2015-2024
Nippon Medical School
2024
The University of Tokyo
2022-2024
Tohoku University
2014-2023
Kitasato University
2023
Keio University
2018
NTT (Japan)
2018
Mitotic catastrophe, a form of cell death that occurs during mitosis and after mitotic slippage to tetraploid state, plays important roles in the efficacy cancer killing by microtubule inhibitors (MTIs). Prolonged arrest spindle assembly checkpoint is well-known requirement for thus conferring sensitivity MTIs. We previously reported turning off activation defined period time another efficient postslippage from we identified SIRT2, member sirtuin protein family, as regulator this process....
Amyloid-β peptides (Aβs) are produced via cleavage of the transmembrane region amyloid precursor protein (APP) by γ-secretase and responsible for Alzheimer's disease. Familial disease (FAD) is associated with APP mutations that disrupt reaction increase production neurotoxic Aβs, i.e., Aβ42 Aβ43. Study activate restore FAD mutants necessary to understand mechanism Aβ production. In this study, using a yeast reconstruction system, we revealed one mutations, T714I, severely reduced cleavage,...
Abstract Background Current strategies that target cytokines (e.g., tumor necrosis factor (TNF)-α), or signaling molecules Janus kinase (JAK)) have advanced the management for allergies and autoimmune diseases. Nevertheless, molecular mechanism underpins its clinical efficacy largely remained elusive, especially in local tissue environment. Here, we aimed to identify genetic, epigenetic, immunological targets of JAK inhibitors (JAKis), focusing on their effects synovial fibroblasts (SFs),...
Long-term submandibular duct obstruction is thought to cause irreversible atrophy and dysfunction of the gland. As an atrophic gland may be induced clinically by chronic or recurrent infection, it generally removed surgically. However, regenerative capacity glands after long-term not completely understood. We studied mouse using aneurysm clip ligation model. documented changes in size, histologic structure gene expression 2 months ligation, 1 week, month removal. Two caused atrophy,...
Abstract Background Recent developments in mass spectrometry (MS) have revealed target antigens for membranous nephropathy (MN), including phospholipase A2 receptor and exostosin 1/exostosin 2 (EXT1/2). EXT1/2 are known of autoimmune disease-related MN, especially lupus nephritis. We describe the case an elderly man who developed nephrotic syndrome followed by progressive renal dysfunction. Case presentation A 78-year-old presented with rapidly dysfunction proteinuria hematuria. Three years...
This study aimed to measure the influence of wearing face masks on individuals' physical status in a hot and humid environment.Each participant experienced different situations: (i) not mask (control), (ii) surgical mask, (iii) sport mask. An ingestible capsule thermometer was used internal core body temperature during exercises (standing, walking, running, each for 20 min) an artificial weather room with wet-bulb globe set at 28°C. The change participants' urinary liver fatty acid-binding...
The salivary gland duct ligation model for the treatment of obstruction caused by stones causes hypofunction gland.However, sufficient results have not been obtained regarding regeneration acinar cells and restoration function, development methods is still ongoing.Here, we administered dental pulp stem cell-derived conditioned medium (DPSC-CM) containing various growth factors to mice examined its effects.The main excretory submandibular was ligated; after 3 weeks, released, Dulbecco's...
The significance of a unique inhibitory Fc receptor for IgG, FcγRIIB (RIIB), in the prevention spontaneous production autoantibodies remains controversial, due mainly to fact that RIIB locus is adjacent autoimmune-related SLAM harboring genes coding signaling lymphocyte activation molecules, making it difficult isolate effect deletion from gene-targeted mice. Our objective was determine influence on development autoimmune diseases and compare with potentially pathogenic SLAM. We established...
The incidence of osteonecrosis the jaw (ONJ) in association with bisphosphonate (BP) preparations (medication-related ONJ, MRONJ) has reportedly increased rapidly recent times. Despite increase, specific cure remains to be established. In this study, MRONJ model rats were constructed, action and effect dental pulp stem cell-conditioned medium (DPSC-CM) on evaluated. Following BP preparation (sodium zoledronate, ZOL) administration via jugular vein, first molar right maxilla was extracted...
Background/Aim: Immune checkpoint inhibitors (ICIs), including nivolumab and pembrolizumab, have recently been shown to clinical benefits in patients with advanced non-small cell lung cancer (NSCLC). The novel tumour responses these agents are changing the management of cancer. Pseudo-progression disease (pseudo-PD), that is, an initial flare followed by shrinkage tumour, has described as a distinctive response ICIs. However, pseudo-PD manifest progression is difficult segregate hyper...
Using trace three-dimensional culture, the collagen gel droplet-embedded culture drug sensitivity test (CD-DST) can be tested even in cases with a small number of cells, including oral squamous cell carcinoma (OSCC), and evaluation antitumor effect concentration close to vivo level is possible. The present report aimed evaluate utility CD-DST assessment vitro efficacy single-agent multidrug combination chemotherapy for OSCC comparison clinical response rates examine possible application such...
The immunotherapy approach using anti-programmed cell death 1 (PD-1) antibody has been demonstrated in oral cancer treatment. However, serious immune-related adverse events (irAE) have reported. If local administration of small doses anti-PD-1 via intraarterial chemoradiotherapy could the same antitumor effect systemic administration, this can reduce irAE and medical expenses. In study, we investigate effects a amount antibody, overall survival (OS), immune environment around cancer.A mouse...
Thymic large cell neuroendocrine carcinoma (LCNEC) is extremely rare. The detailed clinical features of thymic LNCECs remain unknown. A 90-year-old man with a history diabetes mellitus, chronic renal failure, and an abdominal aortic aneurysm underwent computed tomography for follow-up, which showed anterior mediastinal tumor, measuring 31 mm × 28 in diameter. Magnetic resonance imaging iso-intensity mass on T1-weighted images high intensity T2-weighted images. 18F-Fluorodeoxyglucose-positron...