A5053157643- Sepsis Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Hemodynamic Monitoring and Therapy
- Stress Responses and Cortisol
- Acute Kidney Injury Research
- Acute Ischemic Stroke Management
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Liver Disease Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Enhanced Recovery After Surgery
- Erythrocyte Function and Pathophysiology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Adrenal Hormones and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Venous Thromboembolism Diagnosis and Management
- Liver Disease and Transplantation
- Biomedical Research and Pathophysiology
- Vagus Nerve Stimulation Research
- Apelin-related biomedical research
- Chronic Kidney Disease and Diabetes
- Connexins and lens biology
- Thermal Regulation in Medicine
- Cardiac and Coronary Surgery Techniques
- Ferroptosis and cancer prognosis
Cairo University
2014-2024
Cairo University hospitals
2017-2020
Dalhousie University
2013-2018
Universität Greifswald
2011-2012
Augusta University
1977
Encephalopathy is a frequent and lethal consequence of sepsis. Recently, growing body evidence has provided important insights into the role iron dyshomeostasis in context inflammation. The molecular mechanisms underlying its relationship with macrophage phenotypes are largely unknown. Here, we aimed to characterize changes iron-transporter storage proteins microglia phenotype that occur during course sepsis, as well their sepsis-induced encephalopathy. We used cecal ligation puncture (CLP)...
The outcome of patients in septic shock has been shown to be related changes within the microcirculation. Modern imaging technologies are available generate high resolution video recordings microcirculation humans. However, evaluation is not yet implemented routine clinical monitoring critically ill patients. This mainly due large amount time and user interaction required by current analysis software. aim this study was validate a newly developed automated method (CCTools®) for...
Non-infectious uveitis is an inflammatory disease of the eye commonly treated by corticosteroids, though important side effects may result. A main mediator inflammation are oxygen free radicals generated in iron-dependent pathways. As such, we investigated efficacy a novel iron chelator, DIBI, as anti-inflammatory agent local and systemic models endotoxin induced (EIU).Firstly, DIBI EIU Lewis rats were established. 2 hours post intravenous LPS or LPS/DIBI injections, leukocyte activation...
Objective. Encephalopathy and brain edema are serious complications of acute liver injury may lead to rapid death patients. The present study was designed investigate the role inflammatory mediators oxidative stress in cytotoxic oedema neuroprotective effects both minocycline dexamethasone. Methods. 48 male albino rats were divided into 4 groups: control group, (ALI) pretreated ALI dexamethasone group. 24 hours after serum ammonia, enzymes, levels heme oxygenase-1 gene, iNOS gene expression,...
Mitochondrial impairment is recognised as a prominent feature in kidney diseases. Therefore, we investigated whether the effects of resveratrol, L-carnitine, and apelin acute injury model were associated with modulation mitochondrial quality control (QC) related proteins, intra-renal renin-angiotensin (RAS) activity, adenosine triphosphate (ATP) Na+-K+ ATPase gene expression. Rats randomly assigned to 7 groups: Distilled water injected group, DMSO distilled lipopolysaccharide (LPS) LPS...
Tetrahydrobiopterin (BH4), an endogenous nucleic acid derivative, acts as important cofactor for several enzymes found within the vascular endothelium, which is deranged in sepsis.We hypothesized that BH4 would improve capillary density and decrease inflammation intestinal microcirculation of septic rats.We conducted a randomized, controlled trial using two previously validated models sepsis rats: 1) A fecal peritonitis model stent perforating ascending colon, 2) An endotoxemia...
Acute kidney injury (AKI) is a common complication of sepsis, with the burden long hospital admission. Early prediction AKI most effective strategy for intervention and improvement outcomes.In our study, we aimed to investigate predictive performance combined model using ultrasound indices (grayscale Doppler indieces), endothelium (E-selectin, VCAM-1, ICAM1, Angiopoietin 2, syndecan-1, eNOS) as well inflammatory biomarkers (TNF-a, IL-1β) identify AKI.Sixty albino rats were divided into...
Diabetes mellitus (DM) is a multisystem endocrine disorder affecting the brain. Mesenchymal stem cells (MSCs) pretreated with Melatonin have been shown to increase potency of MSCs. This work aimed compare Melatonin, cells, and on cognitive functions markers synaptic plasticity in an animal model type I diabetes (TIDM). Thirty-six rats represented model; six for isolation MSCs 30 were divided into five groups: control, TIDM, TIDM + Stem ex vivo Melatonin. Functional assessment was performed...
Although microcirculation dysfunction plays unique role in septic shock, translation of to clinical practices is limited by current semi-quantities analysis and unclear relevance monitoring. Our aim was critically evaluate the characteristic nature relevant important microcirculation.Pubmed (2000 August 2015) were searched identify observation, case-control, intervention randomized studies evaluating relationship between alterations mortality, morbidity drug responses. The STROBE CONSORT...
Abstract Inflammatory pathway and disruption in glutamate homeostasis join at the level of glia, resulting various neurological disorders. In vitro studies have provided evidence that membrane proteins connexions (Cxs) are involved release, meanwhile, excitatory amino‐acid transporters (EAATs) crucial for reuptake (clearance). Moreover, pannexin‐1 (Panx‐1) activation is more detrimental to neurons. Their expression patterns during inflammation impacts IκB kinase (IKK) inhibition, morphine,...
Anemia in pregnant women is associated with increased maternal and perinatal mortality represents an important economic burden many developing countries. Our goal was to evaluate the impact of anemia on capillary network during pregnancy. Therefore, we compared microcirculatory parameters anemic study participants that non-anemic employing sublingual microcirculation video imaging technology novel automated analysis software.Non-anemic (n = 7) 44) were enrolled at second third trimesters....