A5063697176- Sirtuins and Resveratrol in Medicine
- Anesthesia and Neurotoxicity Research
- Traditional Chinese Medicine Analysis
- Cardiac Ischemia and Reperfusion
- Tryptophan and brain disorders
- RNA modifications and cancer
- interferon and immune responses
- Hepatitis C virus research
- Intensive Care Unit Cognitive Disorders
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Spinal Cord Injury Research
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Functional Brain Connectivity Studies
- Traditional Chinese Medicine Studies
- Hydrogen's biological and therapeutic effects
- Calcium signaling and nucleotide metabolism
- Facial Nerve Paralysis Treatment and Research
- Gut microbiota and health
- Cancer Mechanisms and Therapy
- Anesthesia and Sedative Agents
- Liver Disease Diagnosis and Treatment
Guangxi Medical University
2023-2025
Anhui University of Traditional Chinese Medicine
2024
Integrated Chinese Medicine (China)
2024
Shanghai Jiao Tong University
2021-2024
Theranostics (New Zealand)
2023
Shanghai Ninth People's Hospital
2021
Shanghai East Hospital
2017
Chongqing Medical University
2013
The Affiliated Yongchuan Hospital of Chongqing Medical University
2013
Spinal cord injuries (SCIs) often result in limited prospects for recovery and a high incidence of disability. Melatonin (Mel), hormone, is acknowledged its neuroprotective attributes. Mel was examined this study to discover if it alleviates SCIs via the sirtuin1/dynamin-related protein1 (SIRT1/Drp1) signaling pathway. were simulated mice by inducing contusion at T9–T10 vertebrae causing inflammation primary spinal neurons using lipopolysaccharide (LPS). The findings our demonstrated that...
This study aimed at investigating the effects of propofol on expression hippocampal neuronal nitric oxide synthase (nNOS) and carboxy-terminal PDZ ligand nNOS (CAPON) in stressed rats after electroconvulsive shock (ECS).Sprague-Dawley were repeatedly for 28 days to establish a model. Forty randomly divided into 4 groups (n = 10 each group): group (unapplied group), (applied with intraperitoneal injection 80 mg/kg 7 days), ECS normal saline 8 mL/kg), or + mg/kg). Sucrose preference test,...
The present study aimed to investigate the association between serum SIRT1 protein and severity of spinal cord injury (SCI) as well neurological recovery in mice. In this study, wild-type (WT), Mx1-Cre+ SIRT1loxP/loxP (Mx1), LCK-Cre+SIRT1loxP/loxP (LCK) mice were subjected sham surgery, mild, moderate, or severe SCI, respectively. was collected at intervals 12 h, 1 day (d), 3 d, 5 7 10 14 21 d after injury. locomotor function all animals assessed using Basso mouse scale (BMS) proteins...
Ischemia-reperfusion injury (IRI) has brought attention to flap failure in reconstructive surgery. To improve the prognosis of skin transplantation, we performed experimental IRI by surgical obstruction blood flow and used sodium ferulate (SF) prevent rats. After SF treatment, morphological histological changes flaps were observed H&E Masson's trichrome staining. We also detected expression levels COX-1, HO-1, Ki67 immunohistochemical western blot analysis. Moreover, enzyme-linked...
To explore the effect of electroconvulsive shock (ECS) on glutamate level and hyperphosphorylation tau protein in depressed rats.The depression rat models whose olfactory bulbs were removed established. Using analysis variance factorial design, we set up two intervention factors including electric current (three levels: 25, 50, 75 mA) duration 3, 6, 9 times), which constituted combinations (n=6). Fifty-four adult randomly divided into nine experimental groups (n=6 each group). The...
Background: Hypertrophy of the ligamentum flavum (HLF) is a common contributor to spinal stenosis which results in significant neurological impairments.Circular RNA (circRNA) circ_0003609 has been linked HLF; however, exact mechanism by it causes this disease unclear.Methods: Circ_0003609 expressions were regulated HLF cells overexpression vectors and interference.Cell proliferation fibrosis-related gene expression checked Cell Counting Kit-8 (CCK-8) assay western blotting.CircBank's...
<title>Abstract</title> Ferroptosis, characterized by iron accumulation and lipid peroxidation, has demonstrated anti-tumor properties in multiple malignancies. Long non-coding RNAs (lncRNAs) play a crucial role the tumorigenesis progression of cervical squamous cell cancer (CESC); however, mechanisms underlying actions many lncRNAs ferroptosis remain elusive. Here, expression level LICN-TMPO-AS1 CESC was detected using quantitative real-time polymerase chain reaction. Loss- gain-of-function...
Background: Metformin is a first-line drug widely used in the treatment of type 2 diabetes. It has been shown to improve liver fibrosis; however, underlying mechanism remains unclear. Objectives: This study investigates relationship between metformin and gut microbiota fibrosis. Methods: Carbon tetrachloride (CCl₄) was injected intraperitoneally induce fibrosis mice, followed by for 4 weeks. A CCl₄-induced hepatic mouse model established. The mice were divided into two groups: control...
This study aims to investigate the effect of Linggui Zhugan Decoction(LGZGD) on autophagy in mouse model chronic heart failure(CHF) induced by myocardial infarction(MI), as well regulatory LGZGD hypoxia-inducible factor-1α(HIF-1α)/heme oxygenase-1(HO-1) signaling pathway, based bioinformatics and animal experiments. The active ingredients corresponding targets were retrieved from Traditional Chinese Medicine Systems Pharmacology Analysis Database, GEO, GeneCards, DisGeNET searched for...
Chinese medicinal herb therapy was adopted to treat 68 cases of peripheral facial paralysis. The treatment conducted once daily, with 10 days being a therapeutic course. Following three courses treatments, the results showed reliable and rapid clinical effect that 35 were cured, 17 experienced remarkable effect, 9 had improvement failure in 7 cases, total effective rate 89.7%. And patients whose disease duration within 2 weeks, 97.6%, for over 77.8%, indicating shorter duration, better...
To investigate the effect of benzo(α)pyrene on ATPase activity and content Ca²⁺ in hippocampus neonatal SD rats.Sixty male 60 female 4-days-old rats were randomly divided into 5 groups (n=24): a blank control group, vehicle group (peanut oil), 3 (0.02, 0.2 2 mg/kg, respectively). given (dissolved peanut oil) by gavage daily from postnatal day 4 (PND4) to PND20. The nerve reflex, condition neuro-muscle development motion function examined period treatment. colorimetric technique was used...
Abstract Purpose: Hepatocellular carcinoma, caused by Hepatitis B Virus and C infections other factors, is one of the most common malignant tumors in world. Interferon exerts its biological function inducing expression hundreds Interferon-stimulated genes host cells, which are responsible for inhibiting replication, transcription, important processes Virus. The aim this study was to find proto-oncogenes or oncogenes that can regulate Interferon-β mechanism Interferon-β, identify targets gene...
To explore the effects of different liquid therapies on intracranial pressure, brain water content, and expressions aquaporin-4 N-methyl-D-aspartate-1 in tissue.Two intervention factors including colloids (two levels: 4% gelofusine; 6% hydroxyethyl starch sodium chloride injection) crystal/gel ratios 0:1; 1:1) were set based results analysis variance factorial design. Thirty-two patient who had undergone epilepsy surgery equally randomly divided into four groups: group A (4% gelofusine,...