A5051340701- Shoulder Injury and Treatment
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Venous Thromboembolism Diagnosis and Management
- Elbow and Forearm Trauma Treatment
- Orthopedic Infections and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Knee injuries and reconstruction techniques
- Nerve injury and regeneration
- Shoulder and Clavicle Injuries
- Blood transfusion and management
- Prenatal Screening and Diagnostics
- Family Dynamics and Relationships
- Spine and Intervertebral Disc Pathology
- Total Knee Arthroplasty Outcomes
- Genomics and Rare Diseases
- BRCA gene mutations in cancer
- Hip and Femur Fractures
- Obstructive Sleep Apnea Research
- Cellular Mechanics and Interactions
- Musculoskeletal synovial abnormalities and treatments
- Pancreatic and Hepatic Oncology Research
Maimonides Medical Center
2021-2024
Aligarh Muslim University
2022
University of Toronto
2019
Icahn School of Medicine at Mount Sinai
2018
Institute of Business Management
2017
Memorial Sloan Kettering Cancer Center
2015-2016
Cornell University
2015
Tumor genetic sequencing identifies potentially targetable alterations with therapeutic implications. Analysis has concentrated on detecting tumor-specific variants, but recognition of germline variants may prove valuable as well.To estimate the burden identified through routine clinical tumor sequencing.Patients advanced cancer diagnoses eligible for studies targeted agents at Memorial Sloan Kettering Cancer Center are offered tumor-normal MSK-IMPACT, a 341-gene panel. We surveyed seen in...
Tumor screening for Lynch syndrome is recommended in all or most patients with colorectal cancer (CRC). In metastatic CRC, sequencing of RAS/BRAF necessary to guide clinical management. We hypothesized that a next-generation (NGS) panel identifies and other actionable mutations could also reliably identify tumors DNA mismatch repair protein deficiency (MMR-D) on the basis increased mutational load.We identified CRCs underwent genomic mutation profiling custom NGS assay (MSK-IMPACT) between...
Pancreatic adenocarcinoma (PAC) is part of several cancer predisposition syndromes; however, indications for genetic counseling/testing are not well-defined. In the current study, authors sought to determine mutation prevalence and characteristics that predictive an inherited PAC.A total 175 consecutive patients with PAC who underwent clinical genetics assessment at Memorial Sloan Kettering Cancer Center between 2011 2014 were identified. Clinical data, family history, germline results...
Objective: To evaluate the effectiveness and outcomes of reverse sural artery flap (RSAF) in managing wheel spoke injuries heel a tertiary care setting Pakistan, with an emphasis on its indications, postoperative complications, functional recovery. Study Design: Cross-sectional descriptive study. Place Duration Study: Department Plastic Reconstructive Surgery, PNS Shifa Hospital, Karachi, conducted between August 2024 January 2025. Methodology: Data were collected from patients treated RSAF...
Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa). Although these SNPs been clearly disease risk, their relationship clinical outcomes is less clear. Our aim was to assess the frequency of known PCa susceptibility alleles within a single institution ascertainment and correlate risk disease-specific outcomes. We genotyped 1354 individuals treated for localised between June 1988 December 2007. Blood samples...
Dressing is an Activity of Daily Living (ADL) that can be difficult to do for individuals living with cognitive disorders and can, therefore, negatively impact their quality life. Our research focuses on the development assistive robot smart clothing system aid a user this ADL. In paper, we present our autonomous Clothing Perception System uniquely incorporates sensors into in order perceive if person has worn clothes correctly. Four different dressing states identified: correctly worn;...
Anemia is a modifiable risk factor that may influence postoperative complications following orthopedic surgical procedures. The objective was to determine the of preoperative anemia severity on and length stay (LOS) total elbow arthroplasty (TEA).
1509 Background: Tumor Sequencing (TS) can reveal presumed pathogenic germline variants (PPGV) that may be tumor-relevant (TR) and associated with tumorigenesis. Identification of PPGV have significant implications for the individual family. Methods: To estimate burden TR-PPGV identified in tumor-normal massively parallel sequencing, we analyzed 1,570 cases, unselected cancer type or family history, had undergone TS matched normal DNA using a 341 gene panel employed at MSKCC (MSK-IMPACT)....
Abstract Background Complications after open reduction internal fixation (ORIF) for distal radius fractures (DRFs) are well documented, but the impact of trainee involvement on postoperative outcomes has not been studied. Questions Does affect complication rates and length hospital stay? Methods The American College Surgeons National Surgical Quality Improvement Program was queried from 2006 to 2012 patients undergoing DRF ORIF. A 1:1 propensity score-matched resident/fellow involved cases...
Wide awake local anesthesia no tourniquet (WALANT) techniques are increasingly utilized for hand surgeries in adults, given the clinical benefits to patients, reduced environmental waste during surgery, and lower costs health care system. This technique is not widely employed pediatric concerns parental patient anxiety, noncompliance tolerance of administration anesthesia. Select patients undergoing amenable procedures can potentially benefit from this method enjoy morbidities that adult...
Background Complications after open reduction internal fixation (ORIF) for distal radius fractures (DRF) are well documented, but the impact of trainee involvement on postoperative outcomes has not been studied. Questions Does affect complication rates and length hospital stay? Methods The American College Surgeons National Surgical Quality Improvement Program was queried from 2006 to 2012 patients undergoing DRF ORIF. A 1:1 propensity score matched resident/fellow involved cases...
1528 Background: MMR-D in CRC may be caused by a somatic event, characterized presence of BRAF V600E/MLH1-promoter hypermethylation (BRAF/HM+), or germline mutation an MMR gene, diagnostic Lynch syndrome (LS). In patients with Lynch-like (LLS), the etiology remains unclear (LS germline-, BRAF/HM-) and these receive LS cancer screening recommendations. We sought to determine whether tumor profiling 1) BRAF/HM+, 2) 3) LLS tumors illuminate inherent biologic differences among CRCs. Methods:...
Chronic obstructive pulmonary disease patients have been shown in orthopedic literature to poorer outcomes and higher rates of complications from surgery. In this retrospective review, medical complications, length stay, costs were obtained explore the effects chronic on undergoing primary total shoulder arthroplasty.Total arthroplasty cases January 2005 March 2014 queried analyzed a nationwide database. Study matched 1:5 controls by age, sex, comorbidities associated with disease....
As the prevalence of sleep apnea (SA) increases nationwide, large sample sized studies following primary reverse shoulder arthroplasty (RSA) in SA patients are scarce. Therefore, this study evaluated whether is associated with 1) longer in-hospital lengths stay (LOS) 2) readmissions 3) medical complications and 4) costs.
In the present study, treatment of slaughterhouse wastewater was carried out in a sequential batch reactor. A lab-scale column type reactor fabricated with Perspex material having dimensions 10 cm diameter, 100 height, and an effective volume 7 liters provided ports at different levels. The performance evaluated terms COD, BOD, TSS, TKN, phosphorus removal. operated for 432 days; effectiveness is temperature removal efficiencies COD BOD were84% 80% maximum TSS around 87% TKN’s efficiency 61%...