A5031952335- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- Advanced Photocatalysis Techniques
- Nanoparticle-Based Drug Delivery
- Cyclopropane Reaction Mechanisms
- Photodynamic Therapy Research Studies
- Sulfur Compounds in Biology
- Cancer, Hypoxia, and Metabolism
- MXene and MAX Phase Materials
- Polymer Surface Interaction Studies
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Synthesis and biological activity
- Healthcare and Venom Research
- Fluorine in Organic Chemistry
- Dendrimers and Hyperbranched Polymers
- Chemical Synthesis and Analysis
- Chemical Reactions and Isotopes
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Pickering emulsions and particle stabilization
- Sulfur-Based Synthesis Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Inorganic Fluorides and Related Compounds
Nanjing University of Chinese Medicine
2022-2025
Technologies pour la Santé
2025
Wenzhou Medical University
2024
Nanjing Normal University
2017-2022
Photochemistry Center
2017-2019
Abstract Controlled drug release systems can enhance the safety and availability but avoid side effect of drugs. Herein, concept DNA complementary base pairing rules in biology is used to design prepare a photothermal‐triggered system. Adenine (A) modified polydopamine nanoparticles (A‐PDA, photothermal reagent) effectively bind with thymine (T) Zinc phthalocyanine (T‐ZnPc, photosensitizer) forming A‐PDA = T‐ZnPc (PATP) complex based on A T rules. Similar DNA, whose double strands will break...
As the demand for deuterated compounds continues to rise in medicinal chemistry, various methods have been developed incorporate deuterium atoms. Among these, achieving consecutive trans-dual deuteration remains a challenging task. We designed novel strategy synthesize cyclopropanes at adjacent carbon positions. This approach involves H/D exchange followed by photocatalyzed deuteroaminomethylation of cyclopropenes, with oxide serving as sole source. The reaction is carried out under mild...
The delayed detection and recurrence of cancer lead to disappointing cure rates, underscoring the imperative for exploring precise early tumor diagnosis techniques. Despite superior biocompatibility flexible programmability DNA nanoprobes imaging, intricate designs with multiple oligonucleotide sequences are always indispensable, which significantly hinder their clinical application commercial development. To construct a simply designed nanoprobe, here, we constructed universal...
Abstract The simultaneous application of photothermal therapy (PTT) and photodynamic (PDT) offers substantial advantages in cancer treatment. However, their synergistic anticancer efficacy is often limited by tumor hypoxia, thermotolerance induced high expression heat shock proteins (HSP). Fortunately, hydrogen sulfide (H 2 S), known for its direct cytotoxic effect on cells, has been recognized ability to enhance PTT PDT. effectiveness H S these therapies challenged low loading efficiency,...
A highly operationally convenient and environmentally benign approach of the iodosulfonylation cyclopropenes, styrenes, alkynes in water has been reported.
A highly efficient all-in-one biomimetic nanomedicine approach to overcome hypoxia and achieve tumor targeting theranostics is presented.
Mussel-inspired polydopamine (PDA) has attracted substantial interest in materials synthesis, energy storage, environmental governance, and biomedical science since it was first reported 2007. PDA, owing to its excellent biocompatibility photothermal conversion efficiency ( η ), been used therapy alone combination with photodynamic therapy, chemotherapy, radiation immunotherapy, gas for cancer treatment. This review summarizes the methods synthesizing structurally diverse PDA-based...
Abstract In the context of growing importance heterocyclic compounds across various disciplines, numerous strategies for their construction have emerged. Exploiting distinctive properties cyclopropenes, this study introduces an innovative approach synthesis benzo‐fused five‐membered oxa‐ and aza‐heterocycles through a formal [4+1] cyclization subsequent acid‐catalyzed intramolecular O ‐ to N rearrangement. These transformations exhibit mild reaction conditions wide substrate scope. The...
Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive oxygen species (ROSs) to kill cells. However, a high concentration of reduced glutathione (GSH) is present cells and can consume ROSs sharply reduce the PDT activity. To address this problem, herein, we synthesized thymine modified Zn phthalocyanine (ZnPc, monomer an active form for PDT) prepared its nanoparticle (an aggregator inactive form) with Hg2+ providing driving force "thymine-Hg2+-thymine"...
Despite exhibiting potent anticancer activity, the strong hemolytic properties of melittin (MEL) significantly restrict its delivery efficiency and clinical applications. To address this issue, we have devised a strategy wherein homologous dopamine (DA), an essential component bee venom, is harnessed as vehicle for synthesis MEL-polydopamine (PDA) nanoparticles (MP NPs). The ingenious approach lies in fact that MEL basic polypeptide, polymerization DA also conducted under alkaline...
Nitric oxide (NO) can play both prosurvival and prodeath roles in photodynamic therapy (PDT). The generation efficiency of peroxynitrite anions (ONOO–), by NO superoxide (O2•–), significantly influenced the outcome. Reports indicated that such is closely related to distance between O2•–. Thus, this manuscript, l-arginine (Arg) ethyl ester-modified zinc phthalocyanine (Arg-ZnPc) was designed synthesized as a photosensitizer (PS) donor. Post light irradiation, guanido Arg-ZnPc be effectively...
Abstract Polydopamine (PDA) has been applied widely in electronic elements, environmental management, and biomedical science. However, simple, mild, ultrathin, template‐free 2D PDA (2D‐PDA) fabrication is still a big challenge. Herein, single‐layered 2D‐PDA fabricated via an oxidation‐based exfoliation route by hydrogen peroxide (H 2 O ). The thickness of 3.4 Å, similar to that graphene. Melanin‐like with photothermal conversion rate (η) 27.16% promising hyperthermia agent cancer treatment...
O 2 -evolving hollow polydopamine (HPDA) based on an bubble template is designed as a carrier for zinc phthalocyanine (ZnPc) to fabricate nanomedicine (HZNPs). HZNPs could alleviate tumor hypoxia and enhance PDT-anticancer efficiency.
Beyond the rapid achievements of therapeutic heterobifunctional molecules, some recent efforts have focused on constructing heterotrifunctional aiming at developing more potent and selective agents or emerging additional functions to molecules. However, synthesis these complex molecules requires a specific design lengthy steps. We developed two-step strategy for modular construction enabled by sustainable convenient iodosulfonylation allenes followed SN2′-selective amination. This...
In article number 1803926, Lin Zhou, Shaohua Wei, and co-workers design prepare a controlled release drug delivery system based on the DNA complementary base paring rules in biology between adenine (A) modified polydopamine nanoparticles (A-PDA) thymine (T) zinc phthalocyanine (T-ZnPc). T-ZnPc is effectively released from A-PDA by an NIR light-triggered heating process at tumor position to provide satisfactory suppression efficacy.