A5049494141- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Vibrio bacteria research studies
- Neutropenia and Cancer Infections
- Health and Medical Education
- Hematological disorders and diagnostics
- Problem and Project Based Learning
- Blood disorders and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial biofilms and quorum sensing
- Fungal Infections and Studies
- HER2/EGFR in Cancer Research
- Antibiotic Use and Resistance
- E-Learning and Knowledge Management
- Ovarian cancer diagnosis and treatment
- Innovations in Medical Education
- Infections and bacterial resistance
- Fibroblast Growth Factor Research
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Pneumonia and Respiratory Infections
- Plant Pathogenic Bacteria Studies
HM Hospitales
2019-2025
Hospital Universitario HM Sanchinarro
2020-2025
University of the Basque Country
2015-2025
University College London
2023
Centro Oncológico de Galicia
2019-2022
Hospital Universitario Son Espases
2014-2022
Centre Léon Bérard
2021
Hospital Universitario Virgen de la Arrixaca
2015
Hospital Universitario Virgen Macarena
2015
To validate a prognostic score predicting major complications in patients with solid tumors and seemingly stable episodes of febrile neutropenia (FN). The definition clinical stability implies the absence organ dysfunction, abnormalities vital signs, infections.We developed Clinical Index Stable Febrile Neutropenia (CISNE), six explanatory variables associated serious complications: Eastern Cooperative Oncology Group performance status ≥ 2 (2 points), chronic obstructive pulmonary disease (1...
•Final safety and efficacy results from PERUSE with ∼6 years' median follow-up are consistent CLEOPATRA results.•Results provide reassurance that paclitaxel is a valid alternative to docetaxel first-line pertuzumab trastuzumab.•In exploratory analyses, presence of both visceral disease prior trastuzumab identified subgroup worse PFS. BackgroundThe phase III CLinical Evaluation Of Pertuzumab And TRAstuzumab (CLEOPATRA) trial established the combination pertuzumab, as standard therapy for...
Abstract This nonrandomized, open-label, multi-cohort Phase 1b study (NCT02779751) investigated the safety and efficacy of abemaciclib plus pembrolizumab with/without anastrozole in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) metastatic breast cancer (MBC) without prior CDK4 6 inhibitor exposure. Patients were divided into two cohorts: treatment naïve (cohort 1) pretreated 2). received or 2) over 21-day cycles. The primary...
Invasive candidiasis is a common fungal infection associated with multiple risk factors, such as cancer, neutropenia, corticosteroid therapy, catheterization, and the use of broad-spectrum antibiotic treatment. Candida albicans predominant causative agent, although other species have been emerging in last years, together rise number strains resistant to currently available antifungal drugs, which poses challenge when treating these infections. Drug repurposing drug combinations are promising...
Healthcare-associated infections (HAIs) can be caused by microorganisms present in common practice instruments generating major health problems the hospital environment. The aim of this work was to evaluate disinfection capacity a portable ultraviolet C equipment (UV Sanitizer Corvent® -UVSC-) developed disinfect different objects. For purpose, six pathogens causing HAIs: Acinetobacter baumannii, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida...
Abstract Candida albicans is an opportunistic pathogen that can thrive under adverse conditions including suboptimal pH, nutrient scarcity, and low levels of oxygen. Its pathogenicity associated with the production virulence factors such as extracellular hydrolytic enzymes toxins. This study was aimed at determining effect external substrate nature, strain origin on protease, lipase, hemolysin production. To achieve this objective, agar plate assays were performed pH 5.0, 6.5, 7.5 substrates...
In this study we describe the clinical and molecular characteristics of an outbreak due to carbapenem-resistant Klebsiella pneumoniae (CR-KP) producing CTX-M-15 OXA-48 carbapenemase. Isogenic strains, carbapenem-susceptible K. (CS-KP) CTX-M-15, were also involved in outbreak. From October 2010 December 2012 a total 62 CR-KP 23 CS-KP isolated from samples 42 patients (22 had resistant isolates, 14 susceptible 6 both CR CS isolates). All underlying diseases 17 them (14 with 3 CS-KP) received...
Abstract BACKGROUND: PARP inhibition by olaparib and immune system activation due to PD-L1 binding with durvalumab have been suggested as synergistic strategies. Thus, a comprehensive molecular characterization of tumors treated this combination could support its rational development. Neoadjuvant bladder cancer serve an ideal setting for purpose. METHODS: We designed phase II trial plus analyze the dynamics biomarkers in both pre- post-treatment settings. Twenty-nine patients were enrolled....
TPS4626 Background: Radical cystectomy (RC), traditionally considered the gold standard for MIBC, carries significant morbidity, negatively impacting patients' quality of life. Recent studies have demonstrated that neoadjuvant cisplatin-based chemotherapy combined with immunotherapy can induce a complete or major pathological response in subset patients, allowing consideration less invasive therapeutic alternatives. High comorbidity rates MIBC often preclude radical cystectomy. Sasanlimab,...
4596 Background: Radical cystectomy (RC)is the standard treatment forBCG unresponsive high-risk (HR) NMIBC patients (pts). Pembrolizumab (Pem) was approved by FDA based on Keynote-057 (41% complete response rate (CRR)) and offers a non-surgical option for pts who decline or are ineligible RC. Nadofaregene firadenovec Nogapendekin alfa inbakicept have been recently in this setting. Sacituzumab govitecan (SG) demonstrated encouraging efficacy safety metastatic urothelial cancer (mUC)...
Morphological, physical and chemical properties of both implants prostheses can determine the biofilm formation on their surface increase risk biological complications. The aim this study was to evaluate capacity Candida albicans different materials used manufacture abutments prostheses.Biofilm analyzed cp grade II titanium, cobalt-chromium alloy zirconia, silicone, acrylic resin (polymethylmethacrylate) nano-hybrid composite. Some samples were partially covered with lithium disilicate glass...
Acinetobacter baumannii is an emerging multidrug-resistant pathogen and very little information available regarding its imipenem resistance in Latin American countries such as Bolivia. This study investigated the antimicrobial profile of 46 clinical strains from different hospitals Cochabamba, Bolivia, March 2008 to July 2009, presence carbapenemases a mechanism imipenem. Isolates were obtained patients (one isolate per patient; 30 males,16 females) with age range 1 day 84 years, collected...
In the recent years, there has been a decrease in number of medical professionals dedicated to research career. There is evidence that students with experience during their training acquire knowledge and skills increase probability getting involved more successfully. Degree Medicine (University Basque Country) annual core subject 'Research Project' introduces research. The aim this work was implement project-based learning methodology, working on microbiology, analyse its result along time....
We sought to develop and externally validate a nomogram web-based calculator individually predict the development of serious complications in seemingly stable adult patients with solid tumours episodes febrile neutropenia (FN). The data from FINITE study (n=1133) University Salamanca Hospital (USH) FN registry (n=296) were used this tool. main eligibility criterion was presence apparent clinical stability, defined as events without acute organ dysfunction, abnormal vital signs, or major...
Background The ability of Candida to develop biofilms on inert surfaces or living tissues favors recalcitrant and chronic candidiasis associated, in many instances, with resistance current antifungal therapy.Aim aim this study was evaluate the activity citral, a phytocompound present lemongrass essential oil, monotherapy combined fluconazole against azole-resistant planktonic cells biofilms. effect citral also analysed regard expression resistance-associated genes albicans effectiveness...