A5108058514- Antioxidant Activity and Oxidative Stress
- Food Drying and Modeling
- Phytochemicals and Antioxidant Activities
- Renal cell carcinoma treatment
- Microencapsulation and Drying Processes
- Proteins in Food Systems
- Luminescence Properties of Advanced Materials
- Photosynthetic Processes and Mechanisms
- Polysaccharides Composition and Applications
- Polysaccharides and Plant Cell Walls
- RNA modifications and cancer
- Postharvest Quality and Shelf Life Management
- Bladder and Urothelial Cancer Treatments
- Food composition and properties
- Bone Metabolism and Diseases
- Food Chemistry and Fat Analysis
- Prostate Cancer Diagnosis and Treatment
- Microbial Inactivation Methods
- Renal and Vascular Pathologies
- Trace Elements in Health
- Enzyme Catalysis and Immobilization
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Heavy Metal Exposure and Toxicity
- HVDC Systems and Fault Protection
Ningxia Medical University
2023-2025
Jiangsu Academy of Agricultural Sciences
2016-2025
Xi'an Technological University
2025
Children's Hospital of Zhejiang University
2021-2025
Dalian University
2025
Dalian University of Technology
2025
Ningxia Center for Diseases Prevention and Control
2023-2024
Peking University
2012-2024
Wuhan Red Cross Hospital
2023-2024
Jiangsu University
2019-2024
Background Fucoidan extract (FE), an enzymatically digested compound with a low molecular weight, is extracted from brown seaweed. As natural various actions, FE attractive, especially in Asian countries, for improving the therapeutic efficacy and safety of cancer treatment. The present study was carried out to investigate anti-tumor properties human carcinoma cells further examine underlying mechanisms its activities. Methodology/Principal Finding inhibits growth MCF-7, MDA-MB-231, HeLa,...
Fucoidan, a fucose-rich polysaccharide isolated from brown alga, is currently under investigation as new anti-cancer compound. In the present study, fucoidan extract (FE) Cladosiphon navae-caledoniae Kylin was prepared by enzymatic digestion. We investigated whether combination of FE with cisplatin, tamoxifen or paclitaxel had potential to improve therapeutic efficacy cancer treatment. These co-treatments significantly induced cell growth inhibition, apoptosis, well cycle modifications in...
Abstract Crohn’s disease (CD) is a chronic inflammatory bowel that difficult to treat. However, previous preclinical and clinical studies have shown mesenchymal stromal cells (MSCs) are promising therapeutic approach, whereas the exact underlying molecular mechanisms of MSCs in treating CD remain unclear. Furthermore, heterogeneity MSCs, as well vivo microenvironments may influence efficacy. In our study, we found subpopulation mouse with high expression matrix Gla protein (MGP), one members...
The KangDuo surgical robot (KD-SR) was recently developed in China.
Abstract Background Glycolysis is the key hallmark of cancer and maintains malignant tumor initiation progression. The role N6-methyladenosine (m6A) modification in glycolysis largely unknown. This study explored biological function m6A methyltransferase METTL16 glycolytic metabolism revealed a new mechanism for progression Colorectal (CRC). Methods expression prognostic value was evaluated using bioinformatics immunohistochemistry (IHC) assays. functions CRC analyzed vivo vitro. Glycolytic...
Tribbles pseudokinase 3 (TRIB3) is a member of the mammalian tribbles family and involved in multiple biological processes.However, role TRIB3 renal cell carcinoma (RCC) remains unclear.In this study, we aimed to elucidate functions RCC explore its underlying mechanisms.TRIB3 expression correlation with clinicopathological features was evaluated 123 patients RCC.A series cytological experiments were performed clarify TRIB3, potential molecular regulatory mechanisms explored using...
The senescence of mesenchymal stem cells (MSCs) plays a crucial role in the development and progression systemic lupus erythematosus (SLE). Exosomes, small spherical bilayer proteolipid vesicles, contribute to communication between various their microenvironment by transferring information via cargo, including proteins, lipids, RNAs. While exosomal miRNAs participate biological activities, correlations circulating exosomes with senescent signs BM-MSCs remain unclear. In our study, we aimed...
Objective: To compare the efficacy and safety of robot-assisted laparoscopic radical prostatectomy (RARP) performed using KangDuo surgical robot system to da Vinci Si robotic in clinically localized prostate cancer (KD-RARP vs DV-RARP). Methods: A total 16 patients underwent extraperitoneal KD-RARP by a single experienced surgeon between May 2021 August 2021. The data were prospectively collected. most recent cases DV-RARP same selected from maintained database for comparison prevent...
This study was to investigate the potential mechanisms of treatment with metformin (Met) combined kaempferol (Kae) against postmenopausal osteoporosis. Experiments were conducted in both ovariectomy (OVX)-induced osteoporosis rats and vitro using RAW264.7 cells, MC3T3-E1 HUVECs. Results demonstrated therapeutic effect Met Kae on In vivo, alone combination treatments enhanced tibial trabecular microstructure, bone mineral density (BMD), mechanical properties OVX without causing hepatotoxicity...
Fucoidan, a fucose-rich polysaccharide extracted from brown seaweed, has antitumor, anticoagulant, antiviral, anti-inflammatory, and antibacterial activities. Several studies have shown that fucoidan treatment of cancer cells induced cytotoxicity apoptosis inhibited angiogenesis invasion. We investigated in the present study effect low-molecular-weight (LMWF) on estrogen receptor-negative MDA-MB-231 human breast cells. The LMWF was associated with activation caspases mitochondrial...
The aim of this study was to investigate the utilization ultrasound as a pretreatment method prior drying improve quality button mushroom slices during both hot air and far infrared processes. effects blanching pretreatments upon were analyzed. frequency 40 kHz, power 0.4 W/cm2, energy applied for 3 10 min, respectively. treatment caused reduction time by 9.5% in comparison untreated samples. kinetics improved application, which involved an improvement mass transfer coefficient effective...
Mesenchymal stromal cells (MSCs) show potential for treating cardiovascular diseases, but their therapeutic efficacy exhibits significant heterogeneity depending on the tissue of origin. This study sought to identify an optimal source MSCs disease therapy. We demonstrated that Nestin was a suitable marker cardiac (Nes+cMSCs), which were identified by self-renewal ability, tri-lineage differentiation potential, and expression MSC markers. Furthermore, compared with bone marrow-derived...
Abstract Background Complex changes in the brain microenvironment following traumatic injury (TBI) can cause neurological impairments for which there are few efficacious therapeutic interventions. The reactivity of astrocytes is one keys to microenvironmental changes, such as neuroinflammation, but its role and molecular mechanisms that underpin it remain unclear. Methods Male C57BL/6J mice were subjected controlled cortical impact (CCI) develop a TBI model. specific ligand AXL receptor...
β-Carotene, a typical non-oxygenated carotenoid, is the most efficient source of retinol (VA). The low bio-availability β-carotene lead to large accumulation in colon; however, relationship between and gut microflora remains unclear. This study intends explore interaction using an vitro fermentation model. After 24 h fermentation, degradation rate was (64.28 ± 6.23)%, which 1.46 times that group without microflora. Meanwhile, production VA nearly 2 microflora, indicating can metabolize into...