A5106468043- Genetic and phenotypic traits in livestock
- Animal Genetics and Reproduction
- Renal and related cancers
- Animal Behavior and Welfare Studies
- Genetic Syndromes and Imprinting
- Animal health and immunology
- Glycogen Storage Diseases and Myoclonus
- Thallium and Germanium Studies
- Congenital Anomalies and Fetal Surgery
- Cancer-related gene regulation
- Gastrointestinal disorders and treatments
- Musculoskeletal synovial abnormalities and treatments
- Lymphatic Disorders and Treatments
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Poisoning and overdose treatments
- Orthopedic Surgery and Rehabilitation
- Synthesis and Biological Evaluation
- Spinal Dysraphism and Malformations
- Animal Nutrition and Physiology
- Environmental Science and Technology
- Congenital Diaphragmatic Hernia Studies
- Medical Imaging and Analysis
- Veterinary Orthopedics and Neurology
- Digestive system and related health
University of Veterinary Medicine Vienna
2015-2018
Cattle breeding populations are susceptible to the propagation of recessive diseases. Individual sires generate tens thousands progeny via artificial insemination. The frequency deleterious alleles carried by such may increase considerably within few generations. Deleterious manifest themselves often missing homozygosity resulting from embryonic/fetal, perinatal or juvenile lethality homozygotes. A scan for homozygous haplotype deficiency in 25,544 Fleckvieh cattle uncovered four haplotypes...
In humans, the clinical and molecular characterization of sporadic syndromes is often hindered by small number patients difficulty in developing animal models for severe dominant conditions. Here we show that availability large data sets whole-genome sequences, high-density SNP chip genotypes extensive recording phenotype offers an unprecedented opportunity to quickly dissect genetic architecture conditions livestock. We report on identification seven de novo mutations CHD7, COL1A1, COL2A1,...
Haplotypes with reduced or missing homozygosity may harbor deleterious alleles that compromise juvenile survival. A scan for homozygous haplotype deficiency revealed a short segment on bovine chromosome 19 (Braunvieh 2, BH2) was associated high mortality in Braunvieh cattle. However, the molecular genetic underpinnings and pathophysiology of BH2 remain to be elucidated.The frequency 6.5 % 8,446 animals from national genome databases. Both perinatal calves were higher than average cattle...
Malformations of the spine and spinal cord are common in domestic mammals.1 Among these, syringomyelia is defined as a cystic, fluid filled tubular cavity (syrinx) within extending over several segments. Syringomyelia occurs primary congenital malformation most commonly combined with neural tube defects. However, it can also be acquired after alterations cerebrospinal pressure (CSFP), following rupture hydromyelia, trauma, neoplasia, or inflammation. In chronic cases, cavities lined reactive...
Abstract Background Haplotypes with reduced or missing homozygosity may harbor deleterious alleles that compromise juvenile survival. A scan for homozygous haplotype deficiency revealed a short segment on bovine chromosome 19 (Braunvieh 2, BH2) was associated high mortality in Braunvieh cattle. However, the molecular genetic underpinnings and pathophysiology of BH2 remain to be elucidated. Results The frequency 6.5 % 8,446 animals from national genome databases. Both perinatal calves were...