A5100349893- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Advanced X-ray and CT Imaging
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- COVID-19 and healthcare impacts
- Genomic variations and chromosomal abnormalities
- Acute Myeloid Leukemia Research
- Ovarian cancer diagnosis and treatment
- Mitochondrial Function and Pathology
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Plant tissue culture and regeneration
- Cardiac tumors and thrombi
- Peptidase Inhibition and Analysis
- Toxin Mechanisms and Immunotoxins
- Transgenic Plants and Applications
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
Taizhou First People's Hospital
2008-2024
Fujian Medical University
2020-2022
Union Hospital
2022
Fox Chase Cancer Center
2006
Background: Leptomeningeal metastases (LM), associated with poor prognosis, are frequent complications of advanced non-small cell lung cancer (NSCLC) patients, especially in patients epidermal growth factor receptor (EGFR) mutations. Due to limited access leptomeningeal lesions, the mutational landscape LM has not been comprehensively investigated large cohorts and underlining biology remains elusive. Some studies have explored potential cerebrospinal fluid (CSF) reflecting molecular profile...
Ovarian cancer (OC) metastasis presents major hurdles that must be overcome to improve patient outcomes.Recent studies have demonstrated copy number variations (CNVs) frequently contribute alterations in oncogenic drivers.The present study used a CytoScan HD Array analyse CNVs and loss of heterozygosity (LOH) the entire genomes 6 OC patients human cell lines determine genetic target events leading distinct invasive/migratory capacities OC.The results showed LOH at Xq11.1 Xp21.1 gains 8q21.13...
The quantitative relationship between HER2 copy number and prognosis in positive adjuvant setting remain controversial, few studies have focused on to illustrate the potential clinical relevance of cfDNA. Our study aim develop a novel method quantification explore primary tumors or cfDNA early breast cancer.
TPS8662 Background: Osimertinib is the current standard first-line treatment for advanced non-sq NSCLC with sensitive EGFR mutations. However, previous studies demonstrated that patients concurrent and TP53 mutations had suboptimal clinical benefit EGFR-TKI monotherapy. FLAURA2 study showed osimertinib plus pemetrexed platinum-based chemotherapy significantly improved progression-free survival (PFS) compared monotherapy EGFR-mutated patients. Further needed to better understand benefits of...
Patients with hematologic malignancies are often immunodeficient and therefore have a higher risk of severe symptoms from coronavirus disease 2019 (COVID-19). We retrospectively examined cohort 289 patients 16 hospitals in Zhejiang Province who had COVID-19 during period when the Omicron variant was predominant. Univariate analysis showed that some clinical characteristics, including elder age (P = 0.014), multiple comorbid conditions 0.011), receipt active antineoplastic therapy 0.018) were...
Abstract Background: Compelling evidence has indicated a significant association between leukocyte mitochondrial DNA copy number (mtDNAcn) and prognosis of several malignancies in cancer-specific manner. However, whether mtDNAcn can predict the clinical outcome breast cancer (BC) patients not been well investigated. Methods: The mtDNA peripheral blood leukocytes from 661 BC was measured using Multiplex AccuCopy™Kit based on multiplex fluorescence competitive PCR principle. Kaplan–Meier...