A5016254801- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Heart Rate Variability and Autonomic Control
- Neural dynamics and brain function
- Ultrasound and Hyperthermia Applications
- Pain Management and Treatment
- Nicotinic Acetylcholine Receptors Study
- Cardiac Arrhythmias and Treatments
- Neurological disorders and treatments
- Pulmonary Hypertension Research and Treatments
- Functional Brain Connectivity Studies
- Dialysis and Renal Disease Management
- Heart rate and cardiovascular health
- Non-Invasive Vital Sign Monitoring
- Parathyroid Disorders and Treatments
- Transcranial Magnetic Stimulation Studies
- Nerve injury and regeneration
- Sleep and Wakefulness Research
- Cardiovascular Syncope and Autonomic Disorders
- Atrial Fibrillation Management and Outcomes
- Pancreatitis Pathology and Treatment
- Infrared Thermography in Medicine
- Medication Adherence and Compliance
- Botulinum Toxin and Related Neurological Disorders
Feinstein Institute for Medical Research
2017-2025
Northwell Health
2018-2025
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2022-2025
Hofstra University
2023-2025
Icahn School of Medicine at Mount Sinai
2021-2025
Division of Undergraduate Education
2024
University of Oklahoma Health Sciences Center
2023
AHEPA University Hospital
2020
University of Washington
2008-2019
Neurological Surgery
2010-2012
During active movement the electric potentials measured from surface of motor cortex exhibit consistent modulation, revealing two distinguishable processes in power spectrum. At frequencies <40 Hz, narrow-band decreases occur with over widely distributed cortical areas, while at higher there are spatially more focal increases. These high-frequency changes have commonly been assumed to reflect synchronous rhythms, analogous lower-frequency phenomena, but it has recently proposed that they...
Abstract Tools for noninvasively modulating neural signaling in peripheral organs will advance the study of nerves and their effect on homeostasis disease. Herein, we demonstrate a noninvasive method to modulate specific pathways within using ultrasound (U/S). U/S is first applied spleen cholinergic anti-inflammatory pathway (CAP), US stimulation shown reduce cytokine response endotoxin same levels as implant-based vagus nerve (VNS). Next, hepatic that regulate blood glucose effective VNS...
Inflammation is pathogenically implicated in pulmonary arterial hypertension; however, it has not been adequately targeted therapeutically. We investigated whether neuromodulation of an anti-inflammatory neuroimmune pathway involving the splenic nerve using noninvasive, focused ultrasound stimulation spleen (sFUS) can improve experimental hypertension.
The Neurochip-2 is a second generation, battery-powered device for neural recording and stimulating that small enough to be carried in chamber on monkey's head. It has three channels, with user-adjustable gains, filters, sampling rates, can optimized single unit activity, local field potentials, electrocorticography, electromyography, arm acceleration, etc. Recorded data are stored removable, flash memory card. also separate stimulation channels. Two "programmable-system-on-chips" (PSoCs)...
Cervical vagus nerve stimulation (VNS) is an emerging bioelectronic treatment for brain, metabolic, cardiovascular and immune disorders. Its desired off-target effects are mediated by different fiber populations knowledge of their engagement could guide calibration monitoring VNS therapies.Stimulus-evoked compound action potentials (eCAPs) directly provide information but currently not feasible in humans. A method to estimate through common, noninvasive physiological readouts be used place...
All previous multiple-day brain-computer interface (BCI) experiments have dynamically adjusted the parameterization between signals measured from brain and features used to control interface. The authors present results of a electrocorticographic (ECoG) BCI experiment. A patient with subdural electrode array implanted for seizure localization performed tongue motor tasks. After an initial screening feature selection on 1st day, 5 consecutive days cursor-based feedback were fixed...
Abstract Vagus nerve stimulation (VNS) is a bioelectronic therapy for disorders of the brain and peripheral organs, tool to study physiology autonomic circuits. Selective activation afferent or efferent vagal fibers can maximize efficacy minimize off-target effects VNS. Anodal block (ABL) has been used achieve directional fiber in stimulation. However, evidence VNS with ABL scarce inconsistent, it unknown whether permits respect functional Through series vagotomies, we established...
Implanted vagus nerve stimulation (VNS) delivered concurrently with upper limb rehabilitation has been shown to improve arm function after stroke. Transcutaneous auricular VNS (taVNS) offers a non-invasive alternative implanted and may provide similar therapeutic benefit. There is much discussion about the optimal approach for combining physical therapy, as such we sought determine whether taVNS administered during robotic training, specifically premotor planning stage extension movements,...
Vagus nerve stimulation (VNS) suppresses inflammation and autoimmune diseases in preclinical clinical studies. The underlying molecular, neurological, anatomical mechanisms have been well characterized using acute electrophysiological of the vagus. However, there are several unanswered mechanistic questions about effects chronic VNS, which require solving numerous technical challenges for a long-term interface with vagus mice. Here, we describe scalable model VNS mice developed validated...
Acetylcholine is produced in the spleen response to vagus nerve activation; however, effects on antibody production have been largely unexplored. Here, we use a chronic stimulation (VNS) mouse model study effect of VNS T-dependent B cell responses. We observed lower titers high-affinity IgG and fewer antigen-specific germinal center (GC) cells. GC cells from mice exhibited altered mRNA protein expression suggesting increased apoptosis impaired plasma differentiation. Follicular dendritic...
Abstract Bioelectronic therapies modulating the vagus nerve are promising for cardiovascular, inflammatory, and mental disorders. Clinical applications however limited by side-effects such as breathing obstruction headache caused non-specific stimulation. To design selective functional stimulation, we engineered VaStim, a realistic efficient in-silico model. We developed protocol to personalize VaStim in-vivo using simple muscle responses, successfully reproducing experimental observations,...
The relationship between changes in functional magnetic resonance imaging and neuronal activity remains controversial. Data collected during awake neurosurgical procedures for the treatment of epilepsy provided a rare opportunity to examine this human temporal association cortex. We obtained blood oxygen dependent signals, single local field potentials from 8 300 Hz at 13 cortical sites, nine subjects, paired associate learning control measures. relation signal electrophysiologic parameters...
Intracortical recordings comprise both fast events, action potentials (APs), and slower known as local field (LFPs). Although it is believed that LFPs mostly reflect synaptic activity, unclear which of their signal components are most closely related to would therefore be causally the occurrence individual APs. This issue complicated by significant contribution from AP waveforms, especially at higher LFP frequencies. In single-cell activity human temporal cortex, we computed quantitative,...
Electrocorticography (ECoG) offers a powerful and versatile platform for developing brain-computer interfaces; it avoids the risks of brain-invasive methods such as intracortical implants while providing significantly higher signal-to-noise ratio than noninvasive techniques electroencephalography. The authors demonstrate that both contra- ipsilateral finger movements can be discriminated from ECoG signals recorded single brain hemisphere. activation patterns over sensorimotor areas were...