A5100369491- Genomics and Phylogenetic Studies
- DNA Repair Mechanisms
- Marine Bivalve and Aquaculture Studies
- Aquatic Invertebrate Ecology and Behavior
- Genetic diversity and population structure
- Chromosomal and Genetic Variations
- Genetic Neurodegenerative Diseases
- Pharmacological Effects of Natural Compounds
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Flowering Plant Growth and Cultivation
- Plant Diversity and Evolution
- Cephalopods and Marine Biology
- Plant-based Medicinal Research
- Chemical synthesis and alkaloids
- Computational Drug Discovery Methods
- Photosynthetic Processes and Mechanisms
- Plant responses to water stress
- Forest, Soil, and Plant Ecology in China
- Genetic Syndromes and Imprinting
- Neurobiology and Insect Physiology Research
- Luminescence Properties of Advanced Materials
- Chromatin Remodeling and Cancer
- Phytochemical Studies and Bioactivities
China Three Gorges University
2014-2024
Chinese Academy of Sciences
2012-2023
University of Chinese Academy of Sciences
2012-2023
Kunming Institute of Botany
2023
China Tobacco
2023
Institute of Zoology
2014-2022
Yanshan University
2022
Shanghai Ocean University
2021
Guangdong Medical College
2020-2021
Shangluo University
2019
Heart failure (HF) is the end-stage of cardiovascular diseases, which associated with a high mortality rate and readmission rate. Household early diagnosis real-time prognosis HF at bedside are significant importance. Here, we developed highly sensitive quantitative household platform (termed as UC-LFS platform), integrating smartphone-based reader multiplexed upconversion fluorescent lateral flow strip (LFS). Dual-color core–shell nanoparticles (UCNPs) were synthesized probes for...
As a deubiquitinating enzyme (DUB), the physiological substrates of ataxin-3 (ATX-3) remain elusive, which limits our understanding its normal cellular function and that pathogenic mechanism spinocerebellar ataxia type 3 (SCA3). Here, we identify p53 to be novel substrate ATX-3. ATX-3 binds native polyubiquitinated deubiquitinates stabilizes by repressing degradation through ubiquitin (Ub)-proteasome pathway. deletion destabilizes p53, resulting in deficiency activity functions, whereas...
Traditional Chinese medicine (TCM) had demonstrated effectiveness in the prevention and control of COVID-19. Statistics showed that Ephedra Glycyrrhiza were frequently used treatment We hypothesized Ephedra-Glycyrrhiza drug pair is a potential choice for Here, 112 active compounds identified from via network pharmacology approach. enrichment analysis these might participate cAMP, PI3K-Akt, JAK-STAT chemokine signaling pathways, which high correlation with respiratory, nervous, blood...
The Chk1 protein is essential for genome integrity maintenance and cell survival in eukaryotic cells. After prolonged replication stress, can be targeted proteasomal degradation to terminate checkpoint signaling after DNA repair finishes. To ensure proper activation of damage signaling, a steady-state level needs retained under physiological conditions. Here, we report dynamic pathway that tightly regulates stability. Under unperturbed conditions upon damage, ataxin-3 (ATX3) interacts with...
Abstract Human‐induced disturbances such as dam construction and regulation have led to widespread alterations in hydrological processes thus substantially influence plant characteristics the hydro‐fluctuation zones (HFZs). To reveal utilization of limited resources mechanisms inter‐specific competition species co‐existence communities based on niche breadth overlap under different HFZs Three Gorges Reservoir (TGR) China, we conducted a field investigation with 368 quadrats effects diversity...
Single-celled organisms have different strategies to sense and utilize nutrients in their ever-changing environments. The opportunistic fungal pathogen Candida albicans is a common member of the human microbiota, especially that gastrointestinal (GI) tract. An important question concerns how C. gained competitive advantage over other microbes become successful commensal pathogen. Here, we report uses N-acetylglucosamine (GlcNAc), an abundant carbon source present GI tract, as signal for...
DNA damage response (DDR) is essential for genome stability and human health. Recently, several RNA binding proteins (RBPs), including fused-in-sarcoma (FUS), have been found unexpectedly to modulate this process. The role of FUS in DDR closely linked the pathogenesis amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that affects nerve cells brain spinal cord. Given RBM45 also an ALS-associated RBP, we wondered whether plays any function during Here, report can be...
Plant mitochondrial genomes (mitogenomes) exhibit fluid genome architectures, which could lead to the rapid erosion of synteny over a short evolutionary time scale. Among species-rich orchid family, leafy Cymbidium lancifolium and leafless macrorhizon are sister species with remarkable differences in morphology nutritional physiology. Although our understanding evolution mitochondria is incomplete, these taxa ideal for examining this subject. In study, complete mitogenomes C. macrorhizon,...
Translesion DNA synthesis (TLS) can use specialized polymerases to insert and/or extend nucleotides across lesions, thereby limiting stalled replication fork collapse and the potential for cell death. Recent studies have shown that monoubiquitinated proliferating nuclear antigen (PCNA) plays an important role in recruitment of Y-family TLS forks after damage treatment. To explore possible roles other factors regulate ultraviolet (UV)-induced assembly at arrested forks, we performed...
Thimerosal is a vaccine antimicrobial preservative which has long been suspected an iatrogenic factor possibly contributing to neurodevelopmental disorders including autism. The association between infant thimerosal exposure and autism remains open question. Although removed from mandatory childhood vaccines in the United States, thimerosal-preserved are still widely used outside of States especially developing countries. Notably, thimerosal-containing being given newborns within first 12–24...
A unique riparian ecosystem has been created as a result of anti-seasonal flooding after reservoir operations, which notably influences the distribution patterns plant communities and their functional characteristics in zone. Plant traits reflect physiological ecological processes plants particular ecosystems are crucial for indicating variations structure function. To better understand adaptation strategies to hydrological changes provide scientific basis selection species re-vegetation...
The complete mitochondrial (mt) genome of the Asian green mussel Perna viridis (16,627 bp), an economically important bivalve, was newly sequenced and annotated. P. is shortest has a comparatively highest overall A+T content (68%) among six available genomes marine mussels to date. atp8 gene's length (49 a.a.) unexpectedly greatly shorter than that other (87 a.a.). Comparison gene order demonstrated share no identical blocks although they belong same family, which indicates this group should...
Genetic imprinting, or called the parent-of-origin effect, has been recognized to play an important role in formation and pathogenesis of human diseases. Although epigenetic mechanisms that establish genetic imprinting have a focus many studies, our knowledge about number genes their chromosomal locations interactions with other is still scarce, limiting precise inference architecture complex In this article, we present statistical model for testing estimating effects on diseases using...
// Xuefei Zhu 1, * , Xiaolu Ma 2, Yingfeng Tu Min Huang 2 Hongmei Liu 1 Fengli Wang Juanjuan Gong Jiuqiang Xiaoling Li Qian Chen Hongyan Shen Shu Yun Yang Caixia Guo Tie-Shan Tang State Key Laboratory of Membrane Biology, Institute Zoology, University Chinese Academy Sciences, Beijing 100101, China CAS Genomics and Precision Medicine, Genomics, These authors contributed equally to this work Correspondence to: Guo, email: guocx@big.ac.cn Tang, tangtsh@ioz.ac.cn Keywords: Parkin, translesion...
Abstract Background Species in the subfamily Aphidiinae from Braconidae of Hymenoptera are endoparasitic wasps that exclusively utilize aphids as hosts. Some species widely used biological agents. However, there were only one with determined complete mitochondrial genome this subfamily. Methods and results In study, we sequenced annotated (mitogenome) Binodoxys acalephae , which was 15,116 bp size contained 37 genes. The start codon 13 protein-coding genes ATN, stop TAA TAG assigned to 11...
The mitochondrial (mt) genome of the scallop Mimachlamys senatoria (17,383 bp), an economically and ecologically important bivalve, was newly sequenced annotated. Comparative analyses between M. its congeneric sister species nobilis revealed three new findings: (1) is more prone to use G-rich start/stop codon, variation in codon usage species-correlated rather than gene-correlated, some extent, bears useful phylogenetic information; (2) A + T content unexpectedly low (54.1%) MNR that high...