A5005969373- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Knee injuries and reconstruction techniques
- Mesenchymal stem cell research
- Shoulder Injury and Treatment
- Hip and Femur Fractures
- Foot and Ankle Surgery
- Acute Myeloid Leukemia Research
- Hip disorders and treatments
- Tendon Structure and Treatment
- Lower Extremity Biomechanics and Pathologies
- Sports injuries and prevention
- Periodontal Regeneration and Treatments
- Shoulder and Clavicle Injuries
- Orthopedic Surgery and Rehabilitation
- NF-κB Signaling Pathways
- Tissue Engineering and Regenerative Medicine
- Cell Adhesion Molecules Research
- Hematopoietic Stem Cell Transplantation
- Orthopedic Infections and Treatments
- Advanced Proteomics Techniques and Applications
- Proteoglycans and glycosaminoglycans research
- Diabetic Foot Ulcer Assessment and Management
- Chemokine receptors and signaling
Schön Klinik München Harlaching
2018-2024
Ludwig-Maximilians-Universität München
2011-2022
Paracelsus Medical University
2018-2021
LMU Klinikum
2017-2021
University of Freiburg
2020
Klinikum rechts der Isar
2019
Allgemeine Unfallversicherungsanstalt
2014
München Klinik
2014
Heinrich Heine University Düsseldorf
2004-2009
Zero to Three
2006-2009
Summary Although the link between altered stem cell properties and tissue aging has been recognized, molecular cellular processes of tendon have not elucidated. As tendons contain stem/progenitor cells ( TSPC ), we investigated whether attributes alter during degeneration. Comparing derived from young/healthy (Y‐ ) aged/degenerated human Achilles biopsies (A‐ observed that A‐ exhibit a profound self‐renewal clonogenic deficits, while their multipotency was still retained. Senescence analysis...
Acute ankle injuries are among the most common in emergency departments. However, there still no standardized examination procedures or evidence-based treatment. Therefore, aim of this study was to systematically search current literature, classify evidence, and develop an algorithm for diagnosis treatment acute injuries. We searched PubMed Cochrane Database randomized controlled trials, meta-analyses, systematic reviews or, if applicable, observational studies classified them according...
Although mesenchymal stem cells (MSCs) are the natural source for bone regeneration, exact mechanisms governing MSC crosstalk with collagen I have not yet been uncovered. Cell adhesion to is mostly mediated by three integrin receptors – α1β1, α2β1 and α11β1. Using human (hMSC), we show that α11 subunit exhibited highest basal expression levels but on osteogenic stimulation, both α2 integrins were significantly upregulated. To elucidate possible roles of collagen-binding integrins, applied...
Abstract Human mesenchymal stem cells (hMSC) are a heterogeneous cell population, which is reflected in varying morphological and biological properties. Three subpopulations with intrinsic characteristics can be distinguished: small rapidly self‐renewing cells, spindle‐shaped large, flattened cells. Unfortunately, it has neither been possible to morphologically define these distinct consistently, nor relate them specific surface marker features. Here, the primary hMSC of three donors clearly...
Myelodysplastic syndromes (MDS) are among the most frequent hematologic malignancies. Patients have a short survival and often progress to acute myeloid leukemia. The diagnosis of MDS can be difficult; there is paucity molecular markers, pathophysiology largely unknown. Therefore, we conducted multicenter study investigating whether serum proteome profiling may serve as noninvasive platform discover novel markers for MDS. We generated profiles from 218 individuals by MS identified profile...
Dexamethasone/ascorbic acid/glycerolphosphate (DAG) and bone morphogenic protein (BMP)-2 are potent agents in cell proliferation differentiation pathways. This study investigates the vitro interactions between dexamethasone BMP-2 for an osteoblastic of mesenchymal stem cells (MSCs). Bone marrow-derived human MSCs were cultured with DAG (group A), + B), combined a porous collagen I/III scaffold C). RT-PCR, ELISA, immuncytochemical stainings flow cytometry analysis served to evaluate...
Matrilins (MATN1, MATN2, MATN3 and MATN4) are adaptor proteins of the cartilage extracellular matrix (ECM), which bridge collagen II proteoglycan networks. In humans, dominant-negative mutations in lead to various forms mild chondrodysplasias. However, single or double matrilin knockout mice generated previously our laboratory do not show an overt skeletal phenotype, suggesting compensation among family members. The aim study was establish a mouse line, lacks all four matrilins analyze...
Cyclooxygenase‐2 (COX‐2) is a key enzyme in the production of prostaglandins that are major inflammatory agents. COX‐2 triggered by exposure to various cytokines and bacterial endotoxins. We present here novel role for Ets transcription factor ESE‐1 regulating gene response endotoxin other pro‐inflammatory stimuli. report induction expression lipopolysaccharide (LPS) correlates with monocyte/macrophages. ESE‐1, turn, binds several E26 transformation specific (Ets) sites on promoter. In vitro...
Fractures to the osteoporotic bone feature a delay in callus formation and reduced enchondral ossification. Human mesenchymal stem cells (hMSC), cellular source of fracture healing, are recruited site by cytokines, such as BMP-2 BMP-7. Aim study was scrutinize hMSC for osteoporosis associated alterations BMP mediated migration invasion well extracellular matrix (ECM) binding integrin expression. HMSC were isolated from 18 healthy or donors. Migration assessed using collagen IV coated...
Fractures to the base of fifth metatarsal are common, but their treatment remains controversial. Especially for Lawrence and Botte (L&B) type II fractures, there is conflicting evidence consequently no consensus. Further, many authors consider displacement, articular involvement, number fragments an indication surgery, although missing. The aim this study was evaluate outcome functional all L&B I fractures. Of special interest were influence (1) fracture location (L&B vs. II) (2)...
Background: Patients with complex proximal tibial plateau fractures (TPFs) tend to overestimate the prognosis of their injury, potentially due factors such as a limited understanding, optimism, and influence pain intensity. Understanding reasons behind this misperception is crucial for healthcare providers effectively communicate patients establish realistic expectations treatment outcomes. The purpose study was analyze outcomes TPFs, particular focus on patient-reported outcome measures...
Abstract Surface-enhanced laser desorption/ionization (SELDI) time-of-flight mass spectrometry with protein arrays has facilitated the discovery of disease-specific profiles in serum. Such results raise hopes that may become a powerful diagnostic tool. To this end, reliable and reproducible need to be generated from many samples, accurate peak heights are necessary, experimental variation must known. We adapted entire processing robotics system, thus improving intra-assay coefficients (CVs)...
Coracoid process fractures are rare and often associated with dislocations of the acromioclavicular (AC) joint. There is little evidence about treatment these injuries in adolescents, but few case reports published recommend surgery. We report a dislocated epiphyseal fracture to base coracoid AC joint dislocation 14-year-old ice-hockey player following direct impact his left shoulder. Since magnetic resonance tomography revealed intact coracoclavicular ligaments, we initiated non-operative...
Abstract Purpose Three-dimensional (3D) printed patient-specific instruments (PSI) have been introduced to increase precision and simplify surgical procedures. Initial results in femoral tibial osteotomies are promising, but validation studies on 3D planning, manufacturing of cutting blocks evaluation the attained lacking. Methods In this study, spacers were designed, fabricated, used perform a high osteotomy (HTO). After segmentation CT data sets from 13 human tibiae, digital planning HTO...