A5041505138- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Spinal Dysraphism and Malformations
- Hip disorders and treatments
- Cerebral Palsy and Movement Disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Medical Imaging and Analysis
- Spinal Cord Injury Research
- Cerebrospinal fluid and hydrocephalus
- Congenital Diaphragmatic Hernia Studies
- Connective tissue disorders research
- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Cervical and Thoracic Myelopathy
- Cardiac, Anesthesia and Surgical Outcomes
- Shoulder Injury and Treatment
- Head and Neck Surgical Oncology
- Surgical site infection prevention
- Neonatal and fetal brain pathology
- Anesthesia and Pain Management
- Nerve Injury and Rehabilitation
- Pectus Deformity Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
Shriners Hospitals for Children - Philadelphia
2016-2025
Shriners Hospitals for Children
2011-2025
Orthofix (United States)
2024
The Medical Device (United Kingdom)
2024
Mirus Bio (United States)
2024
Stryker (United States)
2024
Globus Medical (United States)
2017-2024
NuVasive (United States)
2017-2024
Scoliosis Research Society
2023
Shriners Hospitals for Children - Erie
2010-2022
Retrospective review.To report the 2-year results of initial cohort undergoing anterior vertebral body tethering (VBT).Anterior VBT is a promising new technique with abundant preclinical studies but very few clinical results. It growth modulation technique, which utilizes patients' to attain progressive correction their scoliosis. We this procedure.After obtaining institutional review board approval, we retrospectively reviewed our first 11 consecutive patients who underwent follow-up....
Object The gold standard for stereotactic brain biopsy target localization has been frame-based stereotaxy. Recently, frameless techniques have become increasingly utilized. Few authors evaluated this procedure, analyzed preoperative predictors of diagnostic yield, or explored the differences in yield and morbidity rate between techniques. Methods A consecutive series 110 160 image-guided procedures was reviewed. Associated variables both were reviewed compared. All included a risk factor...
In Brief Study Design. Three groups of 6 rats received subtotal cervical spinal cord hemisections followed with marrow stromal cell (MSC) transplants by lumbar puncture (LP), intravenous delivery (IV), or direct injection into the injury (control). Animals survived for 4 21 days. Objective. Cell therapy is a promising strategy treatment (SCI). The mode crucial translation to clinic. Injections directly parenchyma may further damage already compromised tissue; therefore, less invasive methods...
Retrospective review.To report the results of vertebral body stapling (VBS) with minimum 2-year follow-up in patients idiopathic scoliosis.While bracing for scoliosis is moderately successful, its efficacy has been called into question, and it carries associated psychosocial ramifications. VBS shown to be a safe, feasible alternative scoliosis.We retrospectively reviewed 28 29 (96%) treated followed 2 years.Risser sign 0 or 1 coronal curve measuring between 20 degrees 45 .There were 26...
Background: Single-surgeon series investigating the learning curve involved in surgery for spinal deformity may be confounded by changes technology and techniques. Our objective with this multicenter, prospective study was to present a cross-sectional analysis of impact surgeon experience on adolescent idiopathic scoliosis. Methods: All posterior-only surgical procedures scoliosis performed 2007 2008 academic year, minimum two years patient follow-up, were included. Two groups created basis...
Background: Anterior vertebral body tethering (aVBT) has emerged as a novel treatment option for patients with idiopathic scoliosis. We present the results from first U.S. Food and Drug Administration (FDA) Investigational Device Exemption (IDE) study on aVBT. Methods: In this prospective review of retrospective data set, eligible underwent aVBT at single center August 2011 to July 2015. Inclusion criteria included skeletally immature Lenke type-1A or 1B curves between 30° 65°. Clinical...
Ependymal overexpression of brain-derived neurotrophic factor (BDNF) stimulates neuronal addition to the adult striatum, from subependymal progenitor cells. Noggin, by suppressing gliogenesis and increasing availability, potentiates this process. We asked whether BDNF/Noggin might be used recruit new striatal neurons in R6/2 huntingtin transgenic mice. mice injected with adenoviral BDNF Noggin (AdBDNF/AdNoggin) recruited BrdU(+)betaIII-tubulin(+) neurons, which developed as DARPP-32(+)...
The majority of shunt infections occur within 6 months placement and chiefly result from perioperative colonization components by skin flora. Antibiotic-impregnated (AIS) systems have been designed to prevent such colonization. In this study, the authors evaluate incidence infection after introduction an AIS system in a population children with hydrocephalus.The retrospectively reviewed all pediatric patients who had undergone cerebrospinal fluid (CSF) insertion at their institution over...
Object Posterior fossa decompression with duraplasty is routinely used for the treatment of Chiari malformations. It has been traditionally believed that this procedure requires a watertight seal primary closure dura either pericranium or allograft. In study, authors evaluated two synthetic dural substitutes in patient population feasibility use and identification perioperative morbidity. Methods The 56 patients who underwent collagen matrix (Dura-Gen) after suboccipital craniectomy C-1...
Object Several studies have characterized the relationship among postoperative thoracic, lumbar, and pelvic alignment in sagittal plane. However, little is known of between thoracic kyphosis cervical patients with adolescent idiopathic scoliosis (AIS) treated all pedicle screw constructs. The authors examined this associated factors. Methods A prospective database pediatric AIS undergoing spinal fusion 2003 2005 was reviewed for those who received predominantly constructs Lenke Type 1 or 2...
Background: Reporting accurate surgical complication rates to patients and their families is important in the management of adolescent idiopathic scoliosis (AIS). In this study, we report rate major complications following treatment AIS both perioperative period among with a minimum 2 years follow-up. Methods: We reviewed prospectively collected data multicenter registry who underwent during 1995 2014 order identify all complications. A was defined as “major” if it resulted reoperation or...
Background: The true benefits of scoliosis surgery in cerebral palsy (CP) remain uncertain. Our aims were to determine the spinal fusion according health-related quality life (HRQoL) improvement at long-term follow-up and explore effect surgery-related complications on clinical outcomes. Methods: cases consecutive patients who had Gross Motor Function Classification System (GMFCS) level-IV or V with 5-year from a prospective, longitudinal, multicenter database analyzed. Caregivers completed...
In Brief Study Design. A prospective multicenter study and retrospective chart review. Objective. To compare health-related quality of life (HRQOL) measures sagittal deformity in operative Scheuermann kyphosis (SK), adolescent idiopathic scoliosis (AIS), normal populations. Summary Background Data. No to date has evaluated patient reported HRQOL before surgery patients with SK. Methods. data were prospectively collected pretreatment for SK using the SRS-22 outcomes instrument visual analogue...
The Gross Motor Function Classification System (GMFCS) of cerebral palsy categorizes patients by mobility. Patients at GMFCS level 5 are considered the most disabled and high risk hip spine problems, yet they represent a wide spectrum function. Our aim was to subclassify who underwent spinal arthrodesis on basis central neuromotor impairments assess whether subclassification predicted postoperative complications changes in health-related quality life.Using prospective registry, we identified...
Study Design. Retrospective review of a prospective adolescent idiopathic scoliosis (AIS) registry. Objective. To study the evolution operative approach, outcomes, and complication rates in AIS surgery over past 20 years. Summary Background Data. Surgical techniques have evolved considerably We trends management this period their impact on perioperative outcomes. Methods. A total 1819 patients (1995–2013) with 2-year F/U were studied. Operative parameters, major rates, SRS outcomes assessed....
Background: Anterior vertebral body tethering (AVBT) for adolescent idiopathic scoliosis (AIS) is postulated to preserve motion compared with traditional posterior spinal fusion (PSF), but few studies exist date. We used a validated computerized 3D model compare trunk between patients treated PSF and AVBT, analyzed in relation the lowest instrumented vertebra (LIV). Methods: This was single-center retrospective review of consecutive series skeletally immature AIS who underwent analysis prior...