A5066827330- ECG Monitoring and Analysis
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Diabetes Treatment and Management
- COVID-19 Clinical Research Studies
- Cardiac pacing and defibrillation studies
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiac Arrest and Resuscitation
- Genetic factors in colorectal cancer
- Intensive Care Unit Cognitive Disorders
- COVID-19 and healthcare impacts
- Chronic Disease Management Strategies
- Heart Failure Treatment and Management
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Health and Mental Health
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 epidemiological studies
- Sports injuries and prevention
City of Hope
2023-2025
Beckman Research Institute
2023-2025
Aston University
2018-2024
University of Hull
2023-2024
National Health Service
2024
University of Hong Kong
2021-2023
Chinese University of Hong Kong
2018-2023
Diabetes UK
2022
Aston Medical (France)
2018-2021
Duke University Health System
2019
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Introduction: The effects of sodium-glucose cotransporter 2 inhibitors (SGLT2I) and dipeptidyl peptidase-4 (DPP4I) on new-onset cognitive dysfunction in type diabetes mellitus remain unknown. This study aimed to evaluate the two novel antidiabetic agents by comparing rates dementia between SGLT2I DPP4I users. Methods: was a population-based cohort patients treated with January 1, 2015 December 31, 2019 Hong Kong. Exclusion criteria were <1-month exposure or both medication classes, prior...
To compare the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2Is) and dipeptidyl peptidase-4 (DPP4Is) on adverse outcomes in diabetic patients Hong Kong.This was a retrospective population-based cohort study type diabetes mellitus (n = 72,746) treated with SGLT2I or DPP4I between January 1, 2015, December 31, 2020, Kong. Patients exposure to both therapy, without complete demographics mortality data, who had prior atrial fibrillation (AF) were excluded. The new-onset AF,...
Grip strength measurement, as a surrogate of sarcopenia diagnosis, effectively predicts secondary fracture risk in distal radius patients. This simple tool enhances clinical practice by identifying high-risk patients for targeted interventions, potentially preventing or reversing functional decline and recurrent fractures. To evaluate grip hand muscle cross-sectional area predictors with history (DRF), serving surrogates the diagnosis sarcopenia. A retrospective cohort study 745 DRF was...
Objectives Brugada syndrome (BrS) is an ion channelopathy that predisposes affected patients to spontaneous ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death. The aim of this study examine the predictive factors VT/VF. Methods This was a territory-wide retrospective cohort diagnosed with BrS between 1997 2019. primary outcome Cox regression used identify significant risk predictors. Non-linear interactions variables (latent patterns) were extracted using non-negative...
As the most common internal modification of mRNA
Heart failure (HF) involves complex remodelling leading to electrical and mechanical dysfunction. We hypothesized that machine learning approaches incorporating data obtained from different investigative modalities including atrial ventricular measurements electrocardiography echocardiography, blood inflammatory marker [neutrophil-to-lymphocyte ratio (NLR)], prognostic nutritional index (PNI) will improve risk stratification for adverse outcomes in HF compared logistic regression.Consecutive...
Recent studies have reported numerous predictors for adverse outcomes in COVID-19 disease. However, there been few simple clinical risk scores available prompt stratification. The objective is to develop a score predicting severe disease using territory-wide data based on and laboratory variables. Consecutive patients admitted Hong Kong's public hospitals between 1 January 22 August 2020 diagnosed with COVID-19, as confirmed by RT-PCR, were included. primary outcome was composite intensive...
This study aimed to compare the rates of major cardiovascular adverse events in sodium-glucose cotransporter-2 inhibitors (SGLT2I) and dipeptidyl peptidase-4 (DPP4I) users a Chinese population. SGLT2I DPP4I are increasingly prescribed for type 2 diabetes mellitus patients. However, few population-based studies comparing their effects on incident heart failure or myocardial infarction.This was retrospective cohort using electronic health record database Hong Kong, including patients receiving...
Introduction Patients with diabetes mellitus are risk of premature death. In this study, we developed a machine learning-driven predictive model for all-cause mortality among patients type 2 using multiparametric approach data from different domains. Research design and methods This study used territory-wide attending public hospitals or their associated ambulatory/outpatient facilities in Hong Kong between January 1, 2009 December 31, 2009. The primary outcome is mortality. association...
Abstract FTO, the first identified RNA N6-methyladenosine (m6A) demethylase, has been reported by our group to play an oncogenic role in acute myeloid leukemia (AML) and others various solid tumors, including colorectal liver cancers. Additionally, FTO was gene through genome-wide association studies (GWAS) be associated with obesity risk, evidence linking elevated expression increased food intake development. While is a recognized risk factor for cancer, whether serves as shared driving...
Rationale: Despite substantial advancement in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), it remains a leading cause cancer mortality children due to high relapse rate. Moreover, long-term survival rates for adult B-ALL patients are still less than 40%. The carrying MLL rearrangements or BCR-ABL fusion represent high-risk subtypes that face particularly dismal prognoses. This study aims identify innovative therapeutic vulnerability B-ALL. Methods: CRISPR-Cas9 screen was...
OPINION article Front. Physiol., 05 July 2019Sec. Clinical and Translational Physiology Volume 10 - 2019 | https://doi.org/10.3389/fphys.2019.00874
Introduction: Mitral stenosis is associated with an atrial cardiomyopathic process, leading to abnormal electrophysiology, manifesting as prolonged P-wave duration (PWD), larger area, increased dispersion (PWDmax – PWDmin), and/or higher terminal force on lead V1 (PTFV1) the electrocardiogram. Methods: This was a single-centre retrospective study Chinese patients, diagnosed mitral in sinus rhythm at baseline, from single center between November 2009 and October 2016. Automated ECG...
Brugada syndrome (BrS) is a cardiac ion channelopathy with characteristic electrocardiographic patterns, predisposing affected individuals to sudden death (SCD). Implantable cardioverter-defibrillator (ICD) used for primary or secondary prevention in BrS, but its use remains controversial amongst low-risk asymptomatic patients. The present study aims examine indicators ICD implantation BrS patients different disease manifestations.This included who received ICDs between 1997 and 2018. cohort...
Abstract Introduction Neutrophil‐to‐lymphocyte ratio (NLR) is a routinely available biomarker that reflects systemic inflammation. The study evaluated the predictive value of NLR for ischemic stroke and atrial fibrillation (AF) in patients with type 2 diabetes mellitus. Methods This was population‐based cohort mellitus complete blood count tests at baseline between 1 January 1st, 2009, 31 December, government‐funded hospitals/clinics Hong Kong. Follow‐up until 2019, or death. Results A total...