A5026306456- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Animal Ecology and Behavior Studies
- Optical Coherence Tomography Applications
- Bat Biology and Ecology Studies
- Ophthalmology and Visual Impairment Studies
- Circadian rhythm and melatonin
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Advanced Fluorescence Microscopy Techniques
- Optical measurement and interference techniques
- Physiological and biochemical adaptations
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- Corneal Surgery and Treatments
- Sphingolipid Metabolism and Signaling
- Neurological diseases and metabolism
- Sustainable Building Design and Assessment
- Lysosomal Storage Disorders Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Neural dynamics and brain function
- Metabolism and Genetic Disorders
Medical College of Wisconsin
2016-2021
The California Eye Institute
2020
University of Exeter
2016
The foveal avascular zone (FAZ) is altered in numerous diseases. We assessed factors (axial length, segmentation method, age, sex) impacting FAZ measurements from optical coherence tomography (OCT) angiography images.
To develop an automated reference frame selection (ARFS) algorithm to replace the subjective approach of manually selecting frames for processing adaptive optics scanning light ophthalmoscope (AOSLO) videos cone photoreceptors.Relative distortion was measured within individual before conducting image-based motion tracking and sorting into distinct spatial clusters. AOSLO images from nine healthy subjects were processed using ARFS human-derived frames, then aligned undistorted AO-flood by...
With daily electrophysiological recordings and neurochemical analysis, we uncovered a transient period of synaptic imbalance between enhanced inhibition suppressed excitation in rat visual cortical neurons from the end fourth toward fifth postnatal weeks. The expression brain-derived neurotrophic factor (BDNF), which normally enhances suppresses inhibition, was down-regulated during that time, suggesting this may contribute to inhibition/excitation imbalance. An agonist BDNF receptor...
The United Kingdom is currently facing a housing shortage and has been for many years, caused mostly by natural growth in population, immigration an aging stock. solution to combat this problem not as simple constructing hundreds of thousands homes across the country, with setbacks economic, environmental social concerns. design planning individual residential projects, fundamentally sustainable schemes could help mitigate concerns that are causing house building. Building Research...
To mitigate the substantial post-processing burden associated with adaptive optics scanning light ophthalmoscopy (AOSLO), we have developed an open-source, automated AOSLO image processing pipeline both “live” and “full” modes. The live mode provides feedback during acquisition, while full is intended to automatically integrate copious disparate modules currently used in generating analyzable montages. mean (±SD) lag between initiation montage placement for was 54.6 ± 32.7s. reduced overall...
To evaluate different methods of studying cone photoreceptor structure in wild-type (WT) and transgenic pigs carrying the human rhodopsin P23H mutant gene (TgP23H).For vivo imaging, were anesthetized with tiletamine-zolazepam isoflurane given lidocaine-bupivacaine retrobulbar injections. Stay sutures a custom head mount used to hold steer for adaptive optics scanning light ophthalmoscopy (AOSLO). Six WT TgP23H littermates imaged at postnatal day 30 (P30), P90, P180 AOSLO optical coherence...
Proteomics of juvenile rabbit aqueous humor was evaluated before and after surgery to determine proteins responsible for postoperative outcomes.
Background The 13-lined ground squirrel (13-LGS) possesses a cone-dominant retina that is highly amenable to non-invasive high-resolution retinal imaging. ability for longitudinal assessment of photoreceptor mosaic with an adaptive optics scanning light ophthalmoscope (AOSLO) has positioned the 13-LGS become accessible model vision research. Here, we examine interocular symmetry, repeatability, and reliability cone density measurements in 13-LGS. Methods Thirteen (18 eyes) were imaged along...
images of human cone photoreceptors have been shown to vary in their reflectance both spatially and temporally. While it is generally accepted that the unique anatomy physiology themselves drives this behavior, exact mechanisms not fully elucidated as most studies on these phenomena limited retina. Unlike humans, animal models offer ability experimentally manipulate retina perform direct
The adaptive optics scanning light ophthalmoscope (AOSLO) allows cellular resolution imaging of the living retina. accuracy many quantitative measurements made from these images requires accurate estimates lateral scale images. Here, we used trial lenses, which are known to affect relative magnification retinal image, compare empirical measures image with theoretical a four-surface optical model. model overestimated empirically determined change in 70% subjects examined, albeit varying...