A5023717193- Extracellular vesicles in disease
- Bacterial Infections and Vaccines
- Mycobacterium research and diagnosis
- Peptidase Inhibition and Analysis
- Bacteriophages and microbial interactions
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Diverse Scientific Research Studies
- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- Escherichia coli research studies
- Studies on Chitinases and Chitosanases
- Traumatic Brain Injury and Neurovascular Disturbances
- Caveolin-1 and cellular processes
- Advanced Radiotherapy Techniques
- Artificial Intelligence in Healthcare and Education
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Iron Metabolism and Disorders
- Bioeconomy and Sustainability Development
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Resistance in Bacteria
- Radiation Dose and Imaging
- Biochemical and Molecular Research
- Microbial Community Ecology and Physiology
All India Institute of Medical Sciences
2024-2025
Translational Health Science and Technology Institute
2019-2024
Rutgers, The State University of New Jersey
2022-2024
Rutgers Sexual and Reproductive Health and Rights
2023-2024
Maharishi Markandeshwar University, Mullana
2024
Rutgers New Jersey Medical School
2022
Jamia Hamdard
2021
Department of Biotechnology
2021
Abstract Mycobacterium tuberculosis ( Mtb ) secretes extracellular vesicles (EVs) containing a variety of proteins, lipoproteins, and lipoglycans. While emerging evidence suggests that EVs contribute to pathogenesis, the factors molecular mechanisms involved in mycobacterial EV production have not been identified. In this study, we use genetic approach identify proteins mediate vesicle release response iron limitation antibiotic exposure. We uncover critical role for isoniazid‐induced,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection initiates with viral entry in the upper tract, leading to disease 2019 (COVID-19). COVID-19 is characterized by pulmonary pathologies associated failure. Thus, therapeutics aimed at inhibiting of virus or its internalization tract are interest. Herein, we report prophylactic application two intranasal formulations provided National Medicinal Plant Board (NMPB), Anu oil and til tailya, hamster model SARS-CoV-2 infection....
Background Establishing and maintaining gamma knife facility incurs significant costs, mandating healthcare institutions to meticulously assess financial implications for sustainability. Methods This study explores the of setting up operating a Gamma Knife facility, with an aim ascertain user charges achieving breakeven. The was conducted from January June 2019 at largest neurosurgery centre Institute National Importance (INI), in Delhi, India. Applying both Traditional Time-Driven...
Globally, people are in great threat due to the highly spreading of viral infectious diseases. Every year like 100-300 million cases infections found, and among them, above 80% not recognized irrelevant. Dengue virus (DENV) is an arbovirus infection that currently infects most frequently. DENV encompasses four serotypes, they each express comparable sign. From a mild febrile sickness potentially fatal dengue hemorrhagic fever, can induce variety symptoms. Presently, globe being challenged by...
To survive and establish its niche, Mycobacterium tuberculosis (Mtb) engages in a steady battle against an array of host defenses barrage antibiotics. Here, we demonstrate that Mtb employs HupB, nucleoid-associated protein (NAP) as key player to simultaneously these two stress-inducing fronts. Typically, NAPs are bacterial survival under wide environmental or host-mediated stresses. report for different macrophage-induced assaults including acidic pH, nutrient depletion, oxidative...
Extracellular vesicles (EVs) have emerged into a novel vaccine platform, biomarker and nano-carrier for approved drugs. Their accurate detection visualization are central to their utility in varied biomedical fields. Owing the limitations of fluorescent dyes antibodies, here, we describe DNA aptamer as promising tool visualizing mycobacterial EVs vitro. Employing SELEX from large library, identified best-performing that is highly specific binds at nanomolar affinity derived three diverse...
Mycobacterium tuberculosis (Mtb) secretes proteases and peptidases to subjugate its host. Out of sixty plus proteases, atleast three are reported reach host macrophages. In this study, we show that Mtb also delivers a lysyl alanine aminopeptidase, PepN (Rv2467) into macrophage cytosol. Our comparative in silico analysis shows PepNMtb highly conserved across all pathogenic mycobacteria. Non-pathogenic mycobacteria including M. smegmatis (Msm) encode pepN. protein levels both (pathogenic) Msm...
Most bacteria, including mycobacteria, generate extracellular vesicles (EVs). Since bacterial EVs (bEVs) contain a subset of cellular components, metabolites, lipids, proteins, and nucleic acids, several groups have evaluated either the native or recombinant versions bEVs for their protective potency as subunit vaccine candidates. Unlike EVs, are molecularly engineered to one more immunogens interest. Over last decade, different explored diverse approaches generating bEVs. However, here, we...
An erratum was issued for: Enrichment of Native and Recombinant Extracellular Vesicles Mycobacteria. The Authors section updated from:
Abstract Background Establishing and maintaining gamma knife facility incurs significant costs, mandating healthcare institutions to meticulously assess financial implications for sustainability. Methods This study explores the of setting up operating a Gamma Knife facility, with an aim ascertain user charges achieving breakeven. The was conducted from January June 2019 at largest neurosurgery centre Institute National Importance (INI), in Delhi, India. Applying both Traditional Time-Driven...
Background: E. coli is a Gram negative bacterium commonly found in the intestine of animals and humans. Most are harmless but some can cause infection. Antimicrobial resistance public health problem, hence this study was carried out to estimate antimicrobial pattern virulotyping isolates.Methods: During period 2018-19, total 100 faecal samples from goats (n=50) sheep were processed for isolation identification E.coli. All isolates tested against 10 different antibiotics. The prevalence...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection initiates with viral entry in upper tract leading to disease 2019 (Covid-19). Covid-19 is characterized by pulmonary pathologies associated failure. Thus, therapeutics aimed at inhibiting of the virus or its internalization tract, are interest. Herein, we report prophylactic application two intra-nasal formulations provided National Medicinal Plant Board (NMPB), Anu oil and Til tailya SARS-CoV2 hamster model....
Most bacteria, including mycobacteria, generate extracellular vesicles (EVs). Since bacterial EVs (bEVs) contain a subset of cellular components, metabolites, lipids, proteins, and nucleic acids, several groups have evaluated either the native or recombinant versions bEVs for their protective potency as subunit vaccine candidates. Unlike EVs, are molecularly engineered to one more immunogens interest. Over last decade, different explored diverse approaches generating bEVs. However, here, we...