- Biomedical Text Mining and Ontologies
- Renal and related cancers
- Genetics, Bioinformatics, and Biomedical Research
- Bioinformatics and Genomic Networks
- Semantic Web and Ontologies
- Renal cell carcinoma treatment
- Proteoglycans and glycosaminoglycans research
- Developmental Biology and Gene Regulation
- Animal Genetics and Reproduction
- Pluripotent Stem Cells Research
- Urological Disorders and Treatments
- Gene Regulatory Network Analysis
- Genomics and Rare Diseases
- Single-cell and spatial transcriptomics
- Congenital heart defects research
- Philosophy and History of Science
- Birth, Development, and Health
- Corneal Surgery and Treatments
- Cellular Mechanics and Interactions
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Corneal surgery and disorders
- Medical and Biological Sciences
- Scientific Computing and Data Management
- Organ Donation and Transplantation
University of Oxford
2008-2022
University at Buffalo, State University of New York
2013
University Medical Center Groningen
2010
University of Veterinary Medicine Hannover, Foundation
2010
University of Groningen
2010
Wellcome Trust
2010
European Bioinformatics Institute
2010
University of Edinburgh
1999-2009
John Radcliffe Hospital
2008
Oxford Brookes University
2008
A simple technique is described for the preparation of collagen substrata containing 0 1% by weight, in form native bundles with a 640 period, are similar these respects to soft-tissue matrices These substrate hydrated lattices (HCLs) which watery milieu held within fibrous net mainly capillary forces. HCLs have been characterized terms course precipitation and aggregation, ultrastructure, their stability under various conditions. The ways can be employed as both two- three-dimensional cell...
Abstract We describe an ontology for cell types that covers the prokaryotic, fungal, animal and plant worlds. It includes over 680 types. These are classified under several generic categories organized as a directed acyclic graph. The is available in formats adopted by Open Biological Ontologies umbrella designed to be used context of model organism genome other biological databases. freely at http://obo.sourceforge.net/ can viewed using standard visualization tools such OBO-Edit COBrA.
The early chick cornea is composed of an acellular collagenous stroma lined with anterior epithelium and a posterior endothelium. At stage 27-28 development (5 1/2 days), this swells so that the 75-120 mum thick. same time, fibroblasts originate from neural crest begin to invade stroma. Using Nomarski light microscopy, we have compared behavior moving cells in isolated corneas migratory activities artificial collagen lattices on glass. In situ, cyclindrical bodies which extend several thick...
A variety of adherent sarcoma, carcinoma and normal cells are surrounded in vitro by thick, transparent zones (approximately equal to 9 micron thick) that spleen a other particles cannot penetrate. Seven lymphoblastoid cell lines did not possess such halos. The presence these halos around fibrosarcoma appeared protect them from lymphocyte-mediated cytolysis. Hyaluronidase treatment, which destroyed the halo allowed lymphocytes approach tumor membrane, enhanced cytotoxic action immune but...
Abstract Three‐dimensional reconstruction and BrdU incorporation have been used to quantify the development growth of mouse mandible analyse its relationship Meckel's cartilage molar teeth. The anlage is first histologically detectable at E13.5 as paired plates osteoid tissue within condensed mesenchyme (∼0.9 mm long ∼0.36 deep) that are lateral two arms cartilage. Over next 3 days, each plate lengthens ∼3.6 mm, extends medially superior inferior edges, folding over enclose alveolar nerve...
Analysis of biological networks Edited by B. H. Junker ans F. Schreiber . ( ISBN 978-0-470-04144-4. £63.95 .) pp xv + 346 Hoboken : John Wiley & Sons, Inc 2008 It might seem odd for this journal to publish a review book whose index includes no entries anything even remotely anatomical and just solitary mention Homo sapiens, that comment interest. Nevertheless, is content is, in my view, going be considerable importance the next generation research anatomists. The idea there will such may...
Mouse kidney induction proceeds in vitro much as it does vivo: the ureteric bud bifurcates to give collecting ducts while mesenchyme condenses into aggregates which epithelialise and then elongate tubules with glomerular other nephron structures. We report here that factor known LIF (leukaemia inhibitory factor), regulates differentiation growth of embryonic-stem (ES) cells culture, has little effect on or ureteric-bud morphogenesis than stimulate bifurcation process. It however exert a...