A5035854377- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Fluorine in Organic Chemistry
- Crystallography and molecular interactions
- Chemical Synthesis and Analysis
- Luminescence and Fluorescent Materials
- Dendrimers and Hyperbranched Polymers
- Molecular Spectroscopy and Structure
- Supramolecular Self-Assembly in Materials
- Chemical Reaction Mechanisms
- Liquid Crystal Research Advancements
- Carbohydrate Chemistry and Synthesis
- Analytical Chemistry and Chromatography
- Molecular spectroscopy and chirality
- Inorganic Fluorides and Related Compounds
- Peptidase Inhibition and Analysis
- Supramolecular Chemistry and Complexes
- Pesticide Exposure and Toxicity
- Process Optimization and Integration
- RNA Interference and Gene Delivery
- Per- and polyfluoroalkyl substances research
- Amino Acid Enzymes and Metabolism
- Click Chemistry and Applications
- Plant Reproductive Biology
University of Southampton
2014-2024
St. Paul's Hospital
2004
University of British Columbia
1995
Vancouver General Hospital
1995
Clarkson College
1955
Abstract Total and static holdups have been measured for 1/2‐, 1‐in. ceramic Berl saddles, 1‐, 1 1/2‐in. Raschig rings, carbon rings with air rates from 100 to 1,000 1b./(hr.) (sq. ft.) water 10,000 1b./ (hr.) ft.). The holdup measurements motion picture observations of the flow dye solutions through packings provide an explanation great differences observed when gas‐phase mass transfer are by absorption vaporization methods. If effective interfacial area is assumed be proportional total...
Property tuning by fluorination is very effective for a number of purposes, and currently increasingly investigated aliphatic compounds. An important application lipophilicity (log P) modulation. However, the determination log P cumbersome non-UV-active A new variation shake-flask method presented, enabling measurement fluorinated compounds with or without UV activity regardless whether they are hydrophilic lipophilic. No calibration curves measurements compound masses/aliquot volumes...
The intriguing twist-bend nematic (NTB) phase is formed, primarily, by liquid crystal dimers having odd spacers. Typically, the preceded a (N) via weak first-order transition. Our aim to obtain where NTB formed directly from isotropic (I) strong analogy between such behaviour and that of smectic A (SmA)–N–I sequence suggests this new dimer will require short spacer. This expectation consistent with prediction molecular field theory, since decrease in spacer length results an increase...
The transport of anions across biological membranes by small molecules is a growing research field due to the potential therapeutic benefits these compounds. However, little known about exact mechanism which drug-like work and molecular features make good transporter. An extended series 1-hexyl-3-phenylthioureas were synthesized, fully characterized (NMR, mass spectrometry, IR single crystal diffraction) their anion binding properties assessed using 1H NMR titration techniques variety...
The transmembrane transport of anions by small synthetic molecules is a growing field in supramolecular chemistry and has focussed mainly on the chloride. On other hand, highly hydrophilic sulfate anion across lipid bilayers much less developed, even though inability to cellular membranes been linked variety genetic diseases. Tris-thioureas possess high affinities have shown be excellent chloride bicarbonate transporters. Herein we report abilities series tris-ureas tris-thioureas based...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSolid-Phase Dendrimer Synthesis and the Generation of Super-High-Loading Resin Beads for Combinatorial ChemistryVinay Swali, Neil J. Wells, G. John Langley, Mark BradleyView Author Information Department Chemistry, University Southampton, Highfield, Southampton SO17 1BJ, U.K. Cite this: Org. Chem. 1997, 62, 15, 4902–4903Publication Date (Web):July 25, 1997Publication History Received15 May 1997Published online25 July inissue 1...
Small molecule synthetic anion transporters may have potential application as therapeutic agents for the treatment of diseases including cystic fibrosis and cancer. Understanding factors that can dictate transport activity such is a crucial step towards their in biological systems. In this study series acylthiourea were synthesised binding properties POPC bilayers been investigated. The these receptors dominated by lipophilicity, which turn dependent on both substituent effects formation...
Simple, highly fluorinated receptors are shown to function as effective transmembrane anion antiporters with the most active transporters rivalling transport efficacy of natural transporter prodigiosin for bicarbonate.
We report a dynamic covalent approach to transmembrane transport of amino acids by the formation three-component assembly. A mixture squaramide and lipophilic electrophilic aldehyde is shown synergistically highly polar glycine (Gly) across vesicle membranes. The was investigated 13C NMR assay, an osmotic response newly developed fluorescence assay suitable for measuring Gly influx, other assays leakage pH change. proposed occur via hydrogen-bonded anionic hemiaminal/imine, accompanied OH–...
ABSTRACTOne of the current challenges in liquid crystal science is to understand molecular factors leading formation intriguing twist-bend nematic phase (NTB) and determine its properties. During our earlier hunt for NTB created on cooling directly from isotropic not phase, we had prepared 30 symmetric dimers. These odd spacers methylene links two mesogenic groups; desirable but clearly essential features NTB. Here, report phases that dimers exhibit their transition temperatures as functions...
A series of supramolecular diamide organogels containing a reactive compound for the remediation organophosphorus (OP) species, in particular OP chemical warfare agents (CWAs), has been prepared DMSO.
Abstract Total, static, and operating holdups have been measured for 1‐in porcelain carbon Raschig rings 1‐in. Berl saddles, employing aqueous solutions of calcium chloride, sorbitol, a wetting agent as well pure methanol benzene. The range variables covered by this investigation includes liquid rate, 1,000 to 10,000 1b./(hr.) (sq. ft.); viscosity, 0.6 185 cp.; surface tension, 23 86 dynes/cm.; specific gravity, 0.8 1.32. Equations charts are presented estimating all liquids. application...
The formation of tren-based tris-urea supramolecular gels in organic solvents is perturbed by the presence nerve agent soman providing a new method sensing organophosphorus warfare agents.
Abstract Fluorination is commonly exercised in compound property optimization. However, the influence of fluorination on hydrogen‐bond (HB) properties adjacent functional groups, as well HB‐accepting capacity fluorine itself, still not completely understood. Although formation OH⋅⋅⋅F intramolecular HBs (IMHBs) has been established for conformationally restricted fluorohydrins, such interaction flexible compounds remained questionable. Herein demonstrated first time—and contrast to earlier...
Dendrimers are highly ordered, hyperbranched polymers with potential for a whole range of chemical applications. Solution-phase synthesis dendrimers is often challenging, requiring long reaction times and nontrivial purification; solid-phase methodology, on the other hand, enables reactions to be driven completion by using large excess reagents trivial purification. In this paper we show that polyamidoamine may synthesized conveniently efficiently solid support, these molecules good...
Reactions of Fe(C-N-C)(N2)2, 1a, or Fe(C-NMe-C)(N2)2, 1b, C-N-C = 2,6-bis(arylimidazol-2-ylidene)pyridine, C-NMe-C 2,6-bis(arylimidazol-2-ylidene)-3,5-dimethylpyridine, aryl 2,6-iPr2C6H3, with silanes are described. Complex 1a excess SiPhH3 and complex 1b Si(tol)H3, Ph phenyl, C6H5, tol 2-methylphenyl, gave the complexes [Fe(C-N-C)(SiH2Ph)2(η2-H-SiH2Ph)], 2a, [Fe(C-NMe-C)(SiH2tol)2(η2-H-SiH2tol)], 2b, respectively. [Fe(C-NMe-C)(SiH2Ph)2(H)2], 3, which was formulated as a dihydride based on...
Studies of sulfamide, phosphoric triamide and thiophosphoric triamide-based organocatalysts show that the phosphorus containing systems are effective new hydrogen bonding motifs for recognition transport anions.
The role of hydrogen bonding within aggregate formation and CMC: can these properties be predicted by low level computational modelling?
Tautomeric switching is observed in a series of benzimidazole-based anion receptors upon addition basic anions. An N-methylbenzimidazole based receptor selectively interacts with dihydrogen phosphate over variety other putative anionic guests via combination donated and accepted hydrogen bonds.
Abstract Property tuning by fluorination is very effective for a number of purposes, and currently increasingly investigated aliphatic compounds. An important application lipophilicity (log P ) modulation. However, the determination log cumbersome non‐UV‐active A new variation shake‐flask method presented, enabling measurement fluorinated compounds with or without UV activity regardless whether they are hydrophilic lipophilic. No calibration curves measurements compound masses/aliquot...
Solvation of the macrocycle by polar solvents leads to strong binding an N-protected excitatory amino acid neurotransmitter. A 1:1 complex forms highly enantioselectively between and N-Boc-L-glutamate (as dicarboxylate anion, see picture) in CH3CN DMSO (with a larger entropic driving force for binding), but no occurs less competitive solvent CDCl3. Supporting information this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2002/z19311_s.pdf or from author. Please...
A series of neutral ditopic and negatively charged, monotopic host molecules have been evaluated for their ability to bind chloride dihydrogen phosphate anions, organophosphorus species dimethyl methylphosphonate (DMMP), pinacolyl (PMP) the chemical warfare agent (CWA) methylphosphonofluoridate (GD, soman) in organic solvent via hydrogen bonding. Urea, thiourea boronic acid groups are shown anions guests through formation bonds, with urea typically exhibiting higher affinity interactions....
Abstract We describe the synthesis and characterisation of open fullerene ( 1 ) its reduced form 2 in which CH 4 NH 3 are encapsulated, respectively. The H NMR resonance endohedral is broadened by scalar coupling to quadrupolar 14 N nucleus, relaxes rapidly. This broadening absent for small satellite peaks, attributed natural abundance 15 N. influence relaxation mechanism on linewidth ammonia probed variable temperature NMR. A rotational correlation time τ c =1.5 ps. determined , =57±5...
A series of low molecular weight tripodal amide/histidine-containing compounds (1-2) have been synthesised and shown to increase the rate bis-(p-nitrophenyl) phosphate (BNPP) soman (GD) breakdown in buffered aqueous solution.