A5102714014- Photochromic and Fluorescence Chemistry
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Nanocluster Synthesis and Applications
- Conducting polymers and applications
- Radical Photochemical Reactions
- Advanced Sensor and Energy Harvesting Materials
- Photoreceptor and optogenetics research
- Luminescence Properties of Advanced Materials
- Advanced biosensing and bioanalysis techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- 3D Printing in Biomedical Research
- Synthesis of Indole Derivatives
- Polydiacetylene-based materials and applications
- Dielectric materials and actuators
- Neurobiology and Insect Physiology Research
- Molecular Biology Techniques and Applications
- Solar-Powered Water Purification Methods
- Human Resource and Talent Management
- Generative Adversarial Networks and Image Synthesis
- Redox biology and oxidative stress
Pingdingshan University
2025
Macau University of Science and Technology
2025
Xi'an Jiaotong University
2023-2024
Hubei University of Technology
2024
Shenzhen University
2023
Nankai University
1999-2022
State Key Laboratory of Medicinal Chemical Biology
2019-2022
Changchun Institute of Optics, Fine Mechanics and Physics
2010-2019
Chinese Academy of Sciences
2017-2019
University of Chinese Academy of Sciences
2010-2018
Development of enzyme mimics for the scavenging excessive mitochondrial superoxide (O2•- ) can serve as an effective strategy in treatment many diseases. Here, protein reconstruction technology and nanotechnology is taken advantage to biomimetically create artificial hybrid nanozyme. These nanozymes consist ferritin-heavy-chain-based scaffold a metal nanoparticle core active center. This cascade nanozyme possesses dismutase- catalase-like activities also targets mitochondria by overcoming...
Conductive polymer hydrogels (CPHs) are widely employed in emerging flexible electronic devices because they possess both the electrical conductivity of conductors and mechanical properties hydrogels. However, poor compatibility between conductive polymers hydrogel matrix, as well swelling behavior humid environments, greatly compromises CPHs, limiting their applications wearable devices. Herein, a supramolecular strategy to develop strong tough CPH with excellent anti-swelling by...
Abstract Photodynamic therapy (PDT) is a noninvasive protocol for the treatment of various cancers and nonmalignant diseases. Light, oxygen, photosensitizer (PS) are essential three elements in typical PDT process. Currently, there two major barriers limiting further development PDT. One issue limited tissue penetration, other lack high‐performance PSs. Therefore, newly emerging two‐photon excited (2PE‐PDT) has attracted considerable attention recent years due to its advantages such as...
Rationale:Employing in situ bioorthogonal catalysis within subcellular organelles, such as lysosomes, remains a challenge.Lysosomal membranes pose an intracellular barrier for drug sequestration, thereby greatly limiting accumulation and concentrations at intended targets.Here, we provide proof-of-concept report of nanozyme-based strategy that mediates uncaging reactions followed by lysosomal escape the release uncaged drugs into cytoplasm.Methods: A model system composed protein-based...
A new photochromic diarylethene has been synthesized by using thiocarbamide as a functional group and perfluordiarylethene photoswitching trigger via salicylidene Schiff base linkage. The could be used multicontrollable fluorescence switch when triggered base/acid, light, metal ions. results showed that the absorption characteristics of exhibited sequence-dependent responses through efficient interaction specific base-linked unit with tetrabutylammonium hydroxide/trifluoroacetic acid...
Abstract The emergence of nanomedicine has provided a promising strategy to greatly enhance the therapeutic efficacy O 2 ‐dependent photodynamic therapy (PDT). However, plasma‐derived protein corona and/or discontinuous supply substantially limit their tumor delivery efficiency and outcomes. Herein, cloaking‐based cascade nanozymes are developed using genetically engineered human ferritin heavy chain nanocages (FTn) as unique pre‐coated steady suppliers. Specifically, FTn is coated onto...
In order to understand the antiaromaticity of maleimides, enthalpies formation and sublimation N-methylmaleimide, N-methylsuccinimide, N-methylphthalimide, N-benzoyl-N-methylbenzamide were measured. The numerical values for these compounds in solid state are -329.3 +/- 1.4, -469.8 1.6, -325.0 2.1, -239.6 3.8 kJ mol(-)(1), respectively, while corresponding gaseous -256.0 1.5, -389.7 -233.9 2.2, -119.5 respectively. same 73.3 0.5, 80.1 0.3, 91.1 120.1 0.4 We find that maleimides is only modest.
Abstract Enzymes are an important component for bottom‐up building of synthetic/artificial cells. Nanozymes nanomaterials with intrinsic enzyme‐like properties, however, the construction synthetic cells using nanozymes is difficult owing to their high surface energy or large size. Herein, authors show a protein‐based general platform that biomimetically integrates various ultrasmall metal into protein shells. Specifically, eight metal‐based nano‐particles/clusters in situ incorporated...
In this work, boric acid affinity magnetic materials and Au nanorods capped by Ag (AuNRs@Ag) core-shell structure were used to construct the sandwich obtain surface-enhanced Raman scattering (SERS)...
Organoids are 3D artificial miniature organs composed of a cluster self-renewing and self-organizing cells in vitro, which mimic the functions real organs. Nanotechnologies, including preparation nanomaterials fabrication micro/nanostructures, have been proven to promote cell proliferation, guide differentiation, regulate self-organization, showing great promise engineering organoids. In this Perspective, different types nanocomposite hydrogels for organoid culture summarized, effects...
The bottom-up construction of enzyme-based artificial cells is generating increasing interest, but achieving for "all modules" remains challenging in synthetic biology. Here, we introduce a fully cell system by integration biomimetic nanozymes into giant unilamellar vesicles (GUVs). To mimic native peroxidase free radical generation taking advantage Fenton catalysis reactions, designed and prepared de novo nanozyme composed ferritin heavy-chain scaffold protein catalytic Fe3O4 nanoparticles...
Coumarin derivatives modified using bromine atoms linked onto the right benzene ring (mainly in HOMO) could enhance singlet oxygen generation capability.
The immune system can be damaged by chronic stress. However, for this process, the involved molecular alterations and their regulatory roles played in immunosuppression still remain unclear. This study was aimed to identify differences serum protein expressions that are closely associated with effect of stress on function. Serum levels rats control group were measured iTRAQ analysis. Subsequently, among 121 differentially expressed proteins screened between two groups, 46 upregulated...
Abstract Three new asymmetrical diarylethenes containing an azaindole moiety and a variable heteroaryl ring have been synthesized. Their properties, such as photochromism, fatigue resistance, thermal stability, acidichromism, fluorescence, were systematically investigated to elucidate the effects of aromatic stabilization energies (ASE) moieties. The results indicated that stability decreased with increment rings in order thiazyl<thienyl<pyrrolyl. Moreover, dual switching behaviors...