Root canal treatment addresses infectious processes that require control. Occasionally, the radicular pulp is vital and inflamed, presenting a superficial infection. To preserve pulpal remnants, conservative procedures have gained favor, employing anti-inflammatory medications. This study investigated effects of propolis (PRO), copaiba oil-resin (COR) associated with hydrocortisone (H) compared their impact to Otosporin® concerning cytotoxic genotoxic activity, cytokine detection, toxicity...

This paper describes a new method for the preparation of 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one 1 and its derivatives 2-5. set synthetic compounds exhibited high antitumoral activities regarding in vitro screening against several human tumor cell lines as lung carcinoma NCI-460, melanoma UACC-62, breast MCF-7, colon HT-29, renal 786-O, ovarian OVCAR-03 expressing resistance phenotype adriamycin NCI-ADR/RES, prostate PC-3, leukemia K-562. Compounds were also tested murine line...

Este estudo apresenta uma abordagem integrativa para caracterizar e determinar a atividade antioxidante de extratos segunda extração lavanda (Lavandula dentata). O objetivo deste trabalho foi quantificar o teor sólidos solúveis bem como os flavonoides totais etanólicos isopropílicos do resíduo L. dentata. Neste trabalho, foram realizados ensaios antioxidante, determinação flavonóides totais, simulação docking molecular espectro UV-Vis obtidos oriundo processo destilação vapor A análise...

The search for bioactive plant compounds has gained significant attention worldwide in recent decades. Stryphnodendron adstringens (Mart.) Coville, commonly known as barbatimao, is endemic to the Brazilian cerrado and characterized by a high phenolic content its bark, which possesses potential biological activity. This study aimed evaluate antibacterial, antifungal, hemolytic activities of hydroethanolic extract (EHE) S. using disk diffusion method. Additionally, it sought quantify...

A number of herbs belonging to the genus Jatropha Euphorbiaceae family are noted for their medicinal benefits.It has already been observed antibacterial, antiinflammatory, antifungal, antioxidant activity, anti-tumor and others.They also employed as ornamental plants energy crops.Qualitative quantitative methods were used evaluation total phenols flavonoids in latex leaves extract multifida Linn activity.This study was able confirm presence samples analyzed its activity corroborating use...

Abstract Objectives In this study, a collagen-rich biomembrane obtained from porcine ­intestinal submucosa for application in guided bone regeneration was developed and characterized. Then, its biological mechanical properties were compared with that of commercial products (GenDerm [Baumer], Lumina-Coat [Critéria], Surgitime PTFE [Bionnovation], Surgidry Dental F [Technodry]). Materials Methods The extracted intestinal submucosa. Scanning electron microscopy, spectroscopic dispersive energy,...

Propolis is widely known for its important therapeutic activities.In chemical constitution, there are several classes of secondary metabolites, such as simple phenols, carboxylic and cinnamic acids, coumarins, tannins flavonoids.However, flavonoids, an class may be found in small concentrations propolis, which makes quantification difficult.In view this information, the purpose review to present main methodologies used addition proposing new approaches characterization flavonoids using...

We investigated some actions of Withania somnifera on the growth and differentiation hematopoietic precursors [granulocyte/macrophage colony cell formation (CFU-GM)] normal animals EAT bearers, which were treated with different doses (20, 50, or 100 mg/kg/day). also evaluated presence stimulatory factors in animal's serum, as well its survival. Furthermore, we analyzed lymphocyte proliferation, IFN-ɤ, TNF-α concentrations bearing mice. Our results demonstrated effectiveness marrow spleen...

Mikania, guaco é utilizado popularmente há muitos anos, devido às propriedades medicinais atribuídas folhas, incluindo a ação tônica, depurativa, antipirética e broncodilatora, além de estimulante do apetite antigripal. Também empregado no tratamento doenças respiratórias como asma bronquite, na forma xaropes para tosse. Várias dessas ações benéficas à saúde foram comprovadas cientificamente. Estudos publicados sobre direta causando broncodilatação relaxamento da musculatura lisa...

Several types of chocolate were analysed: bitter, half-bitter, milk chocolate, 70% cocoa, white and cocoa seeds.Analysis fat, insoluble solids, total phenols, theobromine caffeine contents antioxidant capacity carried out to evaluate the quality artisan commercial products in Brazil.Fat residues similar those reported literature.We develop a simple method by HPLC-DAD (High-Performance Liquid Chromatography with Diode-Array Detection) quantify methylxanthines whose identification has been...

Abstract: Relevance: This study demonstrated the synergism of various natural preparations in combination with antibiotics, which is a matter high potential therapeutic interest due to de- velopment bacterial resistance these antibiotic drugs. very relevant because it demonstrates that extracts and their association antibiotics may be viable thera- peutic options against pathogens are responsible for incidence nosocomial community infections. Aims: The investigated antibacterial activity...

Brazil is the largest coffee exporter in world. In addition, it occupies second position, among consuming countries of drink. To investigate chemical composition and quality drink from Coffea arabica species, samples grown city Ourinhos, third most productive region state Sao Paulo, a study its properties characteristics was conducted. The pharmacobotanical were investigated performed according to usual techniques these researches through macroscopic microscopic studies cross-sections. oil...

This work describes the synthesis, antinociceptive and anti-inflammatory effect of O-prenyl derivatives: derivatives 2-(3-methylbut-2-enyloxy)acetophenone (L1) 3-methoxy-4-(3-methylbut-2-enyloxy)benzaldehyde (V1). Treatment with L1- or V1-produced on classical pain models: acetic acid abdominal contortions formalin test (first second phases), in hot plate tale flick models mice without changing locomotors performance, anti-oedematogenic vivo: carrageenan-induced paw oedema peritonitis mice....

Some thiophenic derivatives show important biological activity or are used as intermediates in organic synthesis. For this reason, it is very to develop new synthesis procedures with good yields and using few steps. The present work offers an overview of the method for obtaining substituted thiophenes reported literature, synthetic from push-pull systems. In work, we 14 tetrasubstituted starting amino mercaptoacrylates α-brominated acetamides, derived furoyl benzoylacetonitrile,...

O mercado de plantas medicinais no Brasil, é composto por farmácias, drogarias e ervanarias, atualmente sem mínima regulamentação em feiras-livres, não estando livre adulteração e/ou confusão espécies. No comércio as Rubiáceas são habitualmente usadas como adulterantes da Cordia salicifolia Cham. A Casearia sylvestris (guaçatonga) utilizada adulterante (porangaba), a qual comercializada com suposta ação emagrecedora, aumentando desta forma, antrópica sobre espécie. presente trabalho...

Plants are considered important sources of molecules with biological potential. The objective this investigation was to identify tannic compounds, determine antioxidant activity, parameters PH and density, as well the contents soluble solids total flavonoids, in addition phytochemical profile by spectrophotometry visible ultraviolet molecular docking simulation between major compounds present plant extracts Stryphnodendron adstringens (Mart.) Coville. were formulated using a homogeneous...

Abstract Stryphnodendron adstringens (Mart.) Coville, commonly known as “barbatimão,” is native to the Cerrado biome in Brazil and belongs botanical family Fabaceae. The objective of this study was evaluate biological activity crude hydroethanolic extracts formulated from bark, leaves, stems S. adstringens. Soluble solids were determined using incubation drying methodology. Colorimetric methods complexation with ferric chloride employed a qualitative assay identify presence tannins, while...

We investigate the chemical composition of aqueous and hydroethanolic extracts Stryphnodendron adstringens by evaluating total polyphenolic tannin contents, antioxidant activity as well marker compounds UHPLC-MS. Through in silico approach molecular pharmacokinetic parameters were predicted for two major substances found extract, pyrogallol (1) chlorogenic acid (2). The antibacterial was verified determining MIC on different bacterial strains. inhibition zone diameter (ZD) three S. studied,...

As bebidas de infusão são utilizadas desde a antiguidade como medicamentos. De fatos muitos dos medicamentos que hoje fazem parte da alopatia tradicional, provenientes extratos vegetais. Hoje, é possível comprar em Farmácias, drogarias e, até supermercados, folhas e ervas forma industrializada ou semi industrializada. O problema o produto industrializado nem sempre se apresenta “puro”, além possibilitar uso indiscriminado. Alguns fitoterápicos, usados inadequada podem perder as suas...

The aim of this study was to investigate the cytotoxic activity Coriandrum sativum (C. sativum) ethanolic extract (CSEE) in neuroblastoma cells, chemically characterize compounds present CSEE, and predict molecular interactions properties ADME. Thus, after obtaining CSEE performing its chemical characterization through dereplication methods using UPLC/DAD-ESI/HRMS/MS, PM6 SwissADME drug design platform were used order ADME properties. tested for 24 h cells establishment IC50 dose. Then, cell...

A Lavandula dentata L. (Lamiaceae) é utilizada por povos mediterrânicos pelas suas inúmeras aplicações na medicina tradicional. Suas vias secundárias operam produzindo grande variedade de terpenoides voláteis que atuam como eficientes antifúngicos e bactericidas. Logo, objetivou-se nesta pesquisa avaliar o potencial antimicrobiano do hidrolato óleo essencial orgânicos dentata, frente estirpes bacterianas Escherichia coli (ATCC 8739), Staphylococcus aureus 6538 ATCC 25923), Streptococcus...

A Moringa oleifera Lam. é uma espécie de árvore rica em minerais e medicinalmente importante da família Moringaceae, possui ampla gama aplicações, desde a culinária até sua utilização medicinal. vários fitoconstituintes, como flavonoides, carotenoides, isotiocianatos, polifenóis, saponinas, alcaloides, glicosídeos cardiotônicos, carboidratos glicosinolatos. Todas as partes Lam., incluindo sementes, folhas, raízes, flores, caule vagens têm valor medicinal tradicional. As sementes apresentam...

Purpose: The present study evaluated the following caffeoylquinic acids, Neochlorogenic acid (3-CQA), Cryptochlorogenic (4-CQA), Chlorogenic Acid (5-CQA), Isochlorogenic A (3,5-DCQA) B (3,4-DCQA) and C (4,5-DCQA) found in Brazilian green propolis, regarding its physicochemical, pharmacokinetic conformational characteristics. Additionally, compounds were explored on efficacy of inhibiting pharmacological target SARS-CoV-2 Mpro, a protein involved SARS-Cov-2 infection. Methods: physicochemical...