A5010592292- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuropeptides and Animal Physiology
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Gastrointestinal disorders and treatments
- Appendicitis Diagnosis and Management
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Peptidase Inhibition and Analysis
- Gallbladder and Bile Duct Disorders
- Diabetes Treatment and Management
- Genetic factors in colorectal cancer
- Abdominal vascular conditions and treatments
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Gastroesophageal reflux and treatments
- Diet, Metabolism, and Disease
- Colorectal Cancer Screening and Detection
- Gastrointestinal motility and disorders
- Renal Transplantation Outcomes and Treatments
- Abdominal Surgery and Complications
- IgG4-Related and Inflammatory Diseases
Hospital General Universitario de Alicante Doctor Balmis
2013-2025
Instituto de investigación sanitaria y biomédica de Alicante
2016-2025
Yahoo (United Kingdom)
2023
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2016-2019
Bellvitge University Hospital
2019
Universitat Autònoma de Barcelona
1988-2016
Hospital Clínico Universitario de Valencia
2016
Universitat de València
2016
Hospital Clínic de Barcelona
2016
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016
PURPOSE: Previous studies have demonstrated the presence of K-ras mutations in plasma patients with pancreatic carcinoma. However, diagnostic utility and prognostic significance this finding never been addressed. PATIENTS AND METHODS: Forty-four consecutive histologically confirmed primary ductal adenocarcinoma were included. A control group 37 chronic pancreatitis, 10 other tumors area, nine acute four healthy volunteers was also Plasma DNA isolated codon-12 analyzed by means restriction...
Objective: To provide evidence-based recommendations for the management of exocrine pancreatic insufficiency (EPI) after surgery. Background: EPI is a common complication surgery but there certain confusion about its frequency, optimal methods diagnosis, and when how to treat these patients. Methods: Eighteen multidisciplinary reviewers performed systematic review on 10 predefined questions following GRADE methodology. Six external expert referees reviewed retrieved information. Members from...
ObjectivesSerum levels of potassium (K+) appear to be significantly lower in severe cases acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the clinical significance this is unknown. The objective was investigate whether hypokalemia acts as a biomarker severity disease 2019 (COVID-19) pneumonia associated with major outcomes.MethodsA retrospective cohort study inpatients COVID-19 (March 3 May 2, 2020) performed. Patients were categorized according nadir K+ first 72 h...
Abdominal perineal excision (APE) was originally described with levator ani removal for rectal cancer. An even wider, more aggressive extralevator resection APE has been proposed. Although some surgeons are performing a very wide 'extralevator (ELAPE)', there few data to recommend it routinely. This multicentre study aimed compare outcomes of and ELAPE.A propensity case-matched analysis comparing two surgical approaches (APE ELAPE) performed. All patients who underwent abdominoperineal...
The objective of this study was to compare the effects various nutrients (fats, proteins, amino acids, and carbohydrates), given directly into duodenum or colon, on release peptide-YY (PYY) in conscious dogs. As reported previously, showed that plasma levels PYY increased significantly (P less than 0.05) within 15 min response an oral mixed meal. Intraduodenal (ID) administration a fatty acid (oleic acid; 100 mmol/L; ml/h) stimulated robust PYY, whereas ID mixture (phenylalanine plus...
Abstract Introduction Enhanced recovery after surgery (ERAS) has been shown to facilitate discharge, decrease length of stay, improve outcomes and reduce costs. We used this concept design a comprehensive fast‐track pathway (OR‐to‐discharge) before starting our liver transplant activity then applied protocol prospectively every patient undergoing transplantation at institution, monitoring the results periodically. now report first six years results. Patients methods Prospective cohort study...
Early aggressive fluid resuscitation in acute pancreatitis is frequently recommended but its benefits remain unproven. The aim of this study was to determine the outcomes associated with early volume administration emergency room (FVER) patients pancreatitis.A four-center retrospective cohort 1010 conducted. FVER defined as any administered from time arrival 4 h after diagnosis pancreatitis, and divided into tertiles: nonaggressive (<500 ml), moderate (500 1000 (>1000 ml).Two hundred...
The purpose of this study is to investigate the effect peptide YY (PYY) on pentagastrin-, histamine-, and bethanechol-stimulated gastric acid secretion possible mechanisms by which PYY inhibits secretion. Six mongrel dogs with chronic duodenal fistulas were given an intravenous infusion pentagastrin (0.5 microgram . kg-1 h-1), histamine (18 micrograms or bethanechol (80 h-1) either alone simultaneously (100, 200, 400, pmol h-1). 400 inhibited pentagastrin-stimulated in a dose-dependent...
Morbidly obese patients show several common comorbidities associated with immunological alterations such as a sustained low-level proinflammatory profile. Bacterial product translocation is frequent in inflammation-related diseases and may aggravate patients' clinical outcome.Consecutively admitted morbidly who presented indications for bariatric surgery were studied. Before surgery, subjected to modified fasting diet. Patients underwent by sleeve gastrectomy or laparoscopic Roux-en-Y...
To determine the utility of serum amylase (AMY), lipase (Lp), pancreatic isoamylase (isoA), phospholipase A (PLA), and urine AMY in diagnosis acute pancreatitis, samples were obtained on admission every day thereafter for 5 days from 384 patients with abdominal pain. Diagnostic accuracy, determined as area under receiver operating characteristic curve, was > 0.975 AMY, Lp, isoA, AMY. For each these enzymes, a threshold value (twice to sixfold upper limit reference values) offering diagnostic...
Previous studies indicated that laparoscopic surgery could improve postoperative outcomes in acute appendicitis, cholecystitis, perforated gastroduodenal ulcer, or diverticulitis, but some reported opposite results differences the magnitude of improvement. A contemporary analysis using propensity score matching compares is lacking.Over a 6-month period, 38 centres (5% all public hospitals) attending emergency general patients on 24 h, 7 days week basis, enroled consecutive adult who...