A5101870124- Microbial Metabolic Engineering and Bioproduction
- Bacterial Genetics and Biotechnology
- biodegradable polymer synthesis and properties
- Viral Infectious Diseases and Gene Expression in Insects
- Fungal and yeast genetics research
- Liver Disease Diagnosis and Treatment
- Enzyme Structure and Function
- CRISPR and Genetic Engineering
- Biofuel production and bioconversion
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
Nanchang University
2020
State Key Laboratory of Food Science and Technology
2019-2020
Jiangnan University
2019-2020
In metabolic engineering, unbalanced microbial carbon distribution has long blocked the further improvement in yield and productivity of high-volume natural metabolites. Current studies mostly focus on regulating desired biosynthetic pathways, whereas few strategies are available to maximize L-threonine efficiently. Here, we present a strategy guarantee supply reduced cofactors actualize maximization by cellular central pathways. A thermal switch system was designed applied divide whole...
Escherichia coli is an important strain for L-threonine production. Genetic switch a ubiquitous regulatory tool gene expression in prokaryotic cells. To sense and regulate intracellular or extracellular chemicals, bacteria evolve variety of transcription factors. The key enzymes required biosynthesis E. are encoded by the thr operon. operon could coordinate these genes when short supply cell.The thrL leader elements were applied to iclR, arcA, cpxR, gadE, fadR pykF, while...
Abstract Drug‐induced liver injury (DILI) is one of the common adverse effects drug therapy, which closely associated with oxidative stress, apoptosis, and inflammation response. Medium‐chain fatty acids (MCFA) were reported to relieve attenuate stress. However, little has been known about hepatoprotective MCFA in DILI. In present study, acetaminophen (AP) rifampicin (RFP) used establish DILI models LO2 cells, cytoprotective on hepatocellular investigated. Results showed that optimal...