A5087447015- Cellular Mechanics and Interactions
- Cardiomyopathy and Myosin Studies
- Bacillus and Francisella bacterial research
- Yersinia bacterium, plague, ectoparasites research
- Advanced Fluorescence Microscopy Techniques
- Vibrio bacteria research studies
- Microtubule and mitosis dynamics
- Plant-based Medicinal Research
- Cellular transport and secretion
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2018-2021
Morpho (United States)
2021
Centre National de la Recherche Scientifique
2020-2021
Université Grenoble Alpes
2020-2021
Inserm
2020-2021
Laboratoire Physiologie Cellulaire & Végétale
2018-2020
Laboratoire de Physiologie Cellulaire
2020
Université Paris Cité
2020
CEA Grenoble
2018-2020
National University of Singapore
2017
The mechanisms regulating the disassembly of branched actin networks formed by Arp2/3 complex still remain to be fully elucidated. In addition, impact Arp3 isoforms on properties are also unexplored. We now demonstrate that and Arp3B isocomplexes promote assembly equally efficiently but generate with different rates. dissociates significantly faster than from network, its depletion increases stability. This difference is due oxidation Arp3B, not Arp3, methionine monooxygenase MICAL2, which...
Yersinia bacteria cause a range of human diseases, including yersiniosis, Far East scarlet-like fever and the plague. Yersiniae modulate evade host immune defences through injection outer proteins (Yops) into phagocytic cells. One Yops, YopO (also known as YpkA) obstructs phagocytosis disrupting actin filament regulation processes - inhibiting polymerization-promoting signaling sequestration Rac/Rho family GTPases by using monomeric bait to recruit phosphorylate actin-regulating proteins....
Pathogenic Yersinia bacteria cause a range of human diseases. To modulate and evade host immune systems, these yersiniae inject effector proteins into macrophages. One such protein, the serine/threonine kinase YopO (YpkA in pestis), uses monomeric actin as bait to recruit phosphorylate polymerization-regulating proteins, including actin-severing protein gelsolin, disrupt filaments thus impair phagocytosis. However, phosphorylation sites on gelsolin consequences YopO-mediated remodeling have...
Abstract The Arp2/3 complex (Arp2, Arp3 and ARPC1-5) is essential to generate branched actin filament networks for many cellular processes. Human Arp3, ARPC1 ARPC5 exist as two isoforms but the functional properties of iso-complexes largely unexplored. Here we show that Arp3B, not subject regulation by methionine monooxygenase MICAL2, which recruited coronin-1C. Although Arp3B promote assembly equally efficiently in vitro, they have different properties. turns over significantly faster than...