A5070115727- Neurological Disorders and Treatments
- Electrochemical Analysis and Applications
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Diabetic Foot Ulcer Assessment and Management
- Electrochemical sensors and biosensors
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- PI3K/AKT/mTOR signaling in cancer
- Conducting polymers and applications
- Fuel Cells and Related Materials
- Neurological Disease Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Surgical site infection prevention
- Drug-Induced Hepatotoxicity and Protection
- Electrocatalysts for Energy Conversion
- Surgical Sutures and Adhesives
- Neurosurgical Procedures and Complications
- Facial Trauma and Fracture Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Educational Research and Pedagogy
- Mast cells and histamine
- Brain Metastases and Treatment
- Protein Degradation and Inhibitors
- Meningioma and schwannoma management
Research Institute of Emergency Care
1999-2022
Princess Margaret Cancer Centre
2015-2020
Research Institute of Physiology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Medical Sciences
2003
Slovak Academy of Sciences
2002
Institute of Cytology and Genetics
2002
Frumkin Institute of Physical Chemistry and Electrochemistry
1977-2001
Radiation proctitis is a complication of radiation therapy used in the treatment pelvic malignant tumors. The leading clinical symptom this kind late complications recurrent rectal bleeding, to development anemia. Despite availability modern drugs, conservative methods remain ineffective, and minimally invasive endoscopic technologies are not applicable all cases can lead form ulcers fi stulas. About 20 years ago, world scientifi c community recommended hyperbaric oxygenation (HBO) as method...
Relevance . Acute respiratory infection COVID-19 caused by the SARS-CoV-2 (2019-nCov) coronavirus is severe and extremely in 15—20% of cases, which accompanied need for support. Hyperbaric oxygenation recognized as an effective therapy replenishing any form oxygen debt. Aim study To safety HBO use patients with COVID-19. Material metods We examined 32 diagnosis “Coronavirus virus SARS-CoV-2” (10 — moderately (CT 1–2), 22 serious condition 3–4), who received course hyperbaric (HBO). The...
The aim of the stud y is to evaluate efficacy hyperbaric oxygen therapy and its effect on oxidative stress apoptosis in patients with new coronavirus infection COVID-19. Materials methods . 90 diagnosed caused by SARS-CoV-2 virus were examined. Hyperbaric sessions conducted 57 (38 severe condition (CT 3-4), 19 moderate 1-2)). procedures performed 1.4-1.6 ATA mode for 40 minutes, 247 total performed. oxygenation was assessed measuring level saturation, severity blood lymphocytes. Results In...
According to B. Nordenstrom's concept, homeostasis is controlled by biologically closed electrical circuits in the organism. Therefore, a wide application of implanted platinum electrodes medicine for diagnostics and treatment not surprising. Open circuit potentials biological media, termed redox potentials, reflect level pro- antioxidant activities The dynamics shifts towards negative patients with acute cerebral pathology as result hyperbaric oxygenation was investigated. It suggested that...
AKT plays a centralized role in tumor proliferation and survival is aberrantly activated chronic lymphocytic leukemia (CLL). In this phase 2 trial, 30 relapsed/refractory CLL patients were treated with combination afuresertib, novel oral inhibitor, ofatumumab for 6 months, followed by afuresertib maintenance 12 months. We aimed to achieve deeper more durable responses, without requiring long-term continuous treatment. Treatment was generally well tolerated but respiratory infections common,...
The study objective is to analyze the results of surgical treatment patients with endocrine ophthalmopathy using minimally invasive transorbital approaches and intraoperative frameless neuronavigation. Materials methods. was based on examination 9 (17 orbits) in period from 2015 2017. At first stage preoperative computed tomography images orbits imported into navigation software program, then area proposed resection orbit walls marked. Further, operating room, patient head position...
Lenalidomide is a backbone agent in the treatment of multiple myeloma, but dose adjustment required for those with renal impairment (RI). We evaluated pharmacokinetics (PK) and safety lenalidomide dexamethasone as frontline pre-transplant induction, doses adjusted at start each cycle based on creatinine clearance, per official dosing guidelines. After 4 cycles, PK studies showed that patients moderate RI (30 ≤ CrCl < 60 mL/min) receiving 10 mg may be under-dosed severe (CrCl <30ml/min)...
Background. The dura mater tear are quite common in patients with thoracic and lumbar fractures. Prevention management of cerebrospinal fluid leakage sealing the suture is an important stage treatment such patients. Objective: to find optimal surgical tactics for fractures spine tear. Materials methods. This study included 167 operated on concomitant traumatic spinal canal stenosis. We analyzed their clinical data results instrumental examination. All underwent laminectomy at level...
The ability to eliminate any form of oxygen debt by transporting organs and tissues, dissolving it in body fluids, brings hyperbaric oxygenation a new level application transplantology. review discusses the pathophysiological aspects during ischemia reinfusion, especially when used transplantology, also investigations on use model experiments clinical practice. Analysis efficacy therapy at various stages transplantation process (preconditioning, donation, organ storage, early late...
Background . We developed a Protocol based on the results of previous study risk factors for infection postoperative wound: do not use monopolar coagulation skin and subcutaneous fat; remove hemostatic material from wound; relax established wound expander every 65 minutes; refuse to suture muscles in area laminectomy, an intradermal suture. The objective is verification received Protocol. Materials methods A comprehensive retrospective cohort evaluated surgical treatment 575 spinal patients...
In contrast to conventional microsurgery, stereotactic radiosurgery has an advantage in the treatment of intracranial masses, avoiding severe complications associated with open surgery. rare cases, use method is development radiation-induced injuries, one which radiation necrosis (RN). This a late complication radiosurgery, developing mainly 6 months after exposure. The neurological manifestations this depend on location, and clinical picture very diverse. magnetic resonance imaging (MRI)...
This article summarizes our experience in usage of hyperbaric oxygenation (HBO) at patients with acute cerebral pathology received treatment neurointensive care unit. The conducted analysis HBO 750 after surgical because aneurysms, hemorrhagic stroke, head injury and brain tumors showed the possibility safety such patients. principally new strategy for is demonstrated. Thus effectiveness conduction most critically-ill requiring breathing support proven as well absence angiospasm...
Objective. To study the dynamics of arterial blood gas at patients in critical state with intracranial hemorrhages during conduction hyperbaric oxygenation (HBO) under conditions artificial lung ventilation (ALV). Material and methods. We conducted analysis ratio pressure oxygen (РаО) to fraction inspired (FiO 2 ) (Р/F ratio) 113 sessions HBO ALV 43 hemorrhages. was intensive care altitude chamber «Sechrist 2800» (USA), equipped apparatus «Sеchrist-500» (USA). Results. The accompanied by...