A5100387583- MicroRNA in disease regulation
- Thyroid Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Circadian rhythm and melatonin
- Neuroendocrine Tumor Research Advances
- Electrochemical sensors and biosensors
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Natural product bioactivities and synthesis
- Extracellular vesicles in disease
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Reconstructive Surgery and Microvascular Techniques
- Metabolism, Diabetes, and Cancer
- Reconstructive Facial Surgery Techniques
- Ferroptosis and cancer prognosis
- Thyroid and Parathyroid Surgery
- Heat shock proteins research
- Ear and Head Tumors
- FOXO transcription factor regulation
- Neuroscience and Neural Engineering
- Medicinal Plants and Neuroprotection
- Neonatal and Maternal Infections
- Ginseng Biological Effects and Applications
Fujian Medical University
2015-2024
Shaoyang University
2024
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
Shenzhen University
2022-2024
Fuzhou Second Hospital
2024
Fujian Provincial Cancer Hospital
2016-2022
Lanzhou Army General Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Academy of Medical Sciences
2022
Abstract Purpose: Medullary thyroid cancer (MTC) accounts for about 2% of all cancer, but has a relatively poor prognosis compared with differentiated cancer. Anlotinib is novel multitarget tyrosine kinase inhibitor targeting VEGFR, PDGFR, FGFR, and c-Kit. This multicenter, randomized, double-blind, placebo-controlled phase IIB study (ALTER 01031 NCT02586350) was conducted to investigate the efficacy safety anlotinib in MTC. Patients Methods: histopathologically confirmed, unresectable...
An increasing amount of evidence indicates that the inhibition β adrenergic signaling can result in tumor growth. However, role propranolol liver cancer and underlying mechanism remain to be elucidated. The present study aimed investigate cell lines provide for further clinical study. Propranolol was added at different concentrations HepG2 HepG2.2.15 cells HL‑7702 normal human cells. proliferation monitored by live‑cell imaging a range time intervals. Immunofluorescence using DAPI Hoechst...
Metastasis is the leading cause of breast cancer (BC)-related deaths. Circular RNAs (circRNAs) have emerged as essential regulators for progression and metastasis. Therefore, objective this study was to investigate role circRNAs in BC metastasis related mechanism. In study, we established cell line with high or low potential RNA sequencing, migration invasion assay, Fluorescence situ hybridization, luciferase report circRNA pulldown, transmission electron microscopy were performed elucidate...
Type 2 diabetes mellitus (T2DM) has been considered to be a risk factor for numerous human cancers. Hyperglycemia is one of the most direct internal environmental changes patients with T2DM. Increasing evidence reveals that high concentration glucose can promote tumor progression, while its role migration and invasion invasive ductal breast carcinoma (IDBC) cells remains unclear. In present study, it was demonstrated IDBC T2DM suffered an increased size more frequent lymphatic distant...
The aim of the present study was to explore feasibility, safety and effectiveness complete endoscopic radical resection thyroid cancer via an oral vestibule approach. A total 60 patients with unilateral papillary carcinoma were divided into two groups. Half them underwent surgeries approach at Department Head Neck Surgery Fujian Cancer Hospital between November 2014 December 2016. other 30 traditional open surgeries. All lobectomy central neck dissection. Tumor diameter, surgery duration,...
Inflammation and immune dysregulation play critical roles in Kawasaki disease (KD) pathogenesis, yet specific biomarkers signatures remain elusive. This study aims to identify key characterize cell infiltration scores KD using bioinformatic approaches. The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 patients 55 normal controls collected by Imperial College London 2015 2023, was analyzed differentially expressed genes (DEGs). ontology (GO) Kyoto...
The circular RNA circ-PRKCI is an endogenous non-coding that forms a covalently closed ring after reverse splicing, which plays key role in the occurrence and development of multiple digestive system tumors.To investigate mechanism hepatocellular carcinoma (HCC).This study used real-time polymerase chain reaction to detect expression tumor tissues, adjacent blood patients with HCC other cells. A series functional tests were performed explore whether affects growth cells what its HCC....
Abstract Background Accumulating evidence shows that circRNAs comprise a class of non‐coding RNA exhibiting tremendous potential for cancer diagnosis and prognosis they are also implicated in the pathogenesis carcinogenesis. The present study aimed to investigate abnormally expressed thyroid (TC). Materials methods Five pairs TC tissues adjacent nornal specimens were used analyze abnormal circRNA expression using high‐throughput sequencing. MTT Annexin V‐fluorescein isothiocyanate/propidium...
Heat-processed Gynostemma pentaphyllum has shown strong activity against human lung carcinoma A549 cells. In this study, two dammarane-type saponins together with known compounds were isolated from the ethanol extract of heat-processed leaves G. pentaphyllum. They identified as 2α,3β,12β-trihydroxydammar-20(22),24-diene-3-O-β-D-glucopyranoside (1, namely damulin E), 2α,3β,12β-trihydroxydammar-20,24-diene-3-O-β-D-glucopyranoside (2, F), A (3) and B (4), respectively, using NMR mass spectra....
Background: The dysregulated circular RNAs (circRNAs) are relevant to lung adenocarcinoma development. Nevertheless, the function and mechanism of hsa_circ_0020850 (circ_0020850) in development uncertain. Methods: A total 35 patients were recruited, tumor normal tissue samples harvested. A549 PC-9 cells exhibited for experiments vitro. circ_0020850, microRNA-195-5p (miR-195-5p) insulin receptor substrate 2 (IRS2) abundances detected via quantitative reverse transcription-polymerase chain...
Treatment of malignant periorbital tumors requires radical resection the tumor, which can result in creation major eyelid defects. Reconstruction such defects with satisfactory restoration function and aesthetic appearance is difficult. The present patient series describes outcomes achieved a new surgical approach using retroauricular flap palatal mucosal graft. authors reviewed 19 patients created upon between 1994 2012. Upon confirmation defect size, was repaired Then prepared at...
Abstract Previous studies have shown that the heterogeneity of tumor-associated fibroblasts (CAFs) in tumor microenvironment may play a critical role tumorigenesis; however, biological function CAFs pancreatic cancer is still controversial. In this study, we found CD105-positive (CD105 + ) CAF-derived exosomes significantly promoted proliferative and invasive metastatic abilities cells. Furthermore, RNA-seq qRT‒PCR experiments revealed circAMPK1 as key molecule from CD105 mediates malignant...
Abstract Reconstruction of composite oral and maxillofacial defects using free flaps is challenging. The key to such delicate reconstruction lies in the evaluation defect. However, few reports have described clinical classification these difficult defects. In this study, we proposed a method developed different reconstructive solutions flap techniques according classification. This was established based on two parameters (the elements distribution missing tissues). Among 17 patients with...
This study aims to explore the relationship between melatonin (MLT) and gastric cancer angiogenesis by nuclear receptor with ELISA, real‐time quantitative RT‐PCR, IHC, Western blot, siRNA methods. 1. The anti‐angiogenic function of MLT on human cells impact in vitro. was time‐dependent inhibiting proliferation cell lines MGC‐803, SGC‐7901, AGS; Chemical hypoxia simulated 100uM CoCl2 increased SGC‐7901 cells; decreased expression VEGF mRNA protein SGC‐7901; RZR/RORγ SGC‐7901. 2. mechanism...
Precocious puberty (PP) is a developmental disorder. Hypothalamic cells can produce gonadotropin‑releasing hormone (GnRH), the final output of neuroendocrine regulation that occurs during puberty. The aim present study was to investigate role live kinase B1 (LKB1), also known as serine/threonine kinase, in progression PP and identify underlying mechanisms. First, levels LKB1 peripheral blood mononuclear children with were detected by reverse transcription‑quantitative (RT‑q) PCR or western...
Background: In recent years, circular RNAs (circRNAs) have been reported to serve as essential regulators in several human cancers. Nevertheless, the function and mechanism of circRNAs cervical cancer remain elusive. Methods: Flow cytometry assays were performed measure cell apoptosis cycle. Colony Formation transwell chamber migration invasion. Double luciferase reporter for gene analysis was used detect interaction between hsa-circRNA_0001400, miR-326, Akt. Relative protein levels...