A5022689365- Neuroscience and Neuropharmacology Research
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Infective Endocarditis Diagnosis and Management
- Bacterial Identification and Susceptibility Testing
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Clostridium difficile and Clostridium perfringens research
- Bladder and Urothelial Cancer Treatments
- Blood disorders and treatments
- Systemic Lupus Erythematosus Research
- Renal cell carcinoma treatment
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Platelet Disorders and Treatments
- Ureteral procedures and complications
- Polish Legal and Social Issues
- Fungal Infections and Studies
- Medicinal Plants and Neuroprotection
- Indoor Air Quality and Microbial Exposure
- Immune Response and Inflammation
- Otolaryngology and Infectious Diseases
- Vascular Malformations and Hemangiomas
Shizuoka General Hospital
2018-2025
Kurashiki Central Hospital
2023-2025
University of Shizuoka
2024-2025
Otsu Red Cross Hospital
2023
Hokkaido University
2021
Tokyo Institute of Technology
2015
Nagasaki University
2007
Kurume University
1990-1997
Eunice Kennedy Shriver National Institute of Child Health and Human Development
1988
1. The effects of some divalent cations on the A‐current (IA) in cultured rat dorsal root ganglion cells (DRGs) were studied using whole‐cell patch recording. 2. IA was not affected by omission calcium from external medium; however it significantly depressed manganese (10 mM) applied pressure ejection. This depressant effect resulted a depolarizing shift activation curve 17 mV, associated with only slight reduction maximum conductance. At 10 mM also caused steady‐state inactivation 34 mV....
Summary The macrolide antibiotics are now well known to have anti-inflammatory effects. Because dendritic cells (DCs) orchestrate immune responses, we examined the in vitro effects of clarithromycin (CAM), azithromycin (AZM) and midecamycin (MDM) on expression co-stimulatory molecules production cytokines [interleukin (IL)-10, IL-6, interferon (IFN)-γ, IL-12p40, tumour necrosis factor (TNF)-α] murine bone marrow-derived DCs by lipopolysaccharide (LPS) stimulation. A 15-membered macrolide,...
Abstract This study aimed to assess the effects of thienopyridine-class antiplatelet agents (including ticlopidine, clopidogrel, and prasugrel) on bleeding complications in patients who underwent robot-assisted radical prostatectomy. cohort used a database for prostatectomy at 23 tertiary centers nationwide between 2011 2022. Patients received thienopyridines (thienopyridine group) were compared with those aspirin monotherapy (aspirin group). The primary outcome was incidence complications....
1. Cultured dorsal root ganglion cells of the bullfrog were voltage-clamped in whole-cell configuration. 2. An adenosine 3':5'-cyclic monophosphate (cyclic AMP)-dependent cationic inward rectifier (IH) was inhibited by bath application enflurane (0.2-0.8 mM) and halothane (0.2-0.5 mM), which thereby induced an outward current at resting potential, a membrane hyperpolarization unclamped cells. 3. The main effect (0.5 to displace steady-state IH activation curve hyperpolarizing direction about...
Adjustment of initial vancomycin (VCM) dosage has been recommended on the basis renal function nomogram in therapeutic drug monitoring guidelines Japan. However, this not clinically validated, and few studies have focused its usefulness patients with risk augmented function. Therefore, study aimed to evaluate validity VCM association between patient conditions related accuracy.In retrospective study, we screened data 398 who received had estimated glomerular filtration rates ≥30 mL·min·1.73...
Abstract Backgrounds Actinomyces species are gram-positive, obligate anaerobic rods and rare causes of cholecystitis. Because bacteria, it is difficult for to survive in bile apart from A. naeslundii. We experienced a case recurrent acute cholecystitis caused by odontolyticus. Case presentation A patient had been diagnosed with treated one month before after that, admitted our hospital because Gram stain the revealed gram-positive cocci. found odontolyticus MRSA culture blood culture....
Gentamicin is a commonly used antibiotic with synergistic effects that administered once or multiple times daily. However, the influence of daily administration frequency on renal function has not yet been identified. This study aimed to investigate effect dosing worsening in patients receiving gentamicin.
To evaluate the impact of relative dose intensity for gemcitabine-cisplatin chemotherapy in patients with metastatic urothelial carcinoma.We retrospectively reviewed medical records 18 carcinoma, who received regimen as first-line between 2009 and 2015. The doses gemcitabine cisplatin were reduced or intervals treatment cycles prolonged according to efficacy adverse events during first second cycles. individually optimal was set actual per standard From third course onward, same intensity....
Abstract Background Saccharomyces cerevisiae is ubiquitous in the gastrointestinal tract and known as brewer's or baker's yeast. We experienced a case of S. Candida glabrata co-infectious bloodstream infection . It rare to detect both species blood cultures together. Case treated 73-year-old man who developed pancreaticoduodenal fistula after pancreaticoduodenectomy. The patient had fever on postoperative day 59. took detected C. Thus, we started micafungin. On 62, retested cultures, S...
Infections caused by Robinsoniella peoriensis, particularly bacteremia, are rare, of which only six cases were reported R. peoriensis bloodstream infections. This case report describes an instance bacteremia arising while we treated the patient with piperacillin-tazobactam. We 84-year-old female peritoneal carcinoma and febrile neutropenia using The patient's fever subsided. However, she developed a again on fourth day treatment Blood cultures taken at this time positive for peoriensis....
Abstract Background The differences in the clinical pharmacy services (CPS) provided by oncology and non‐oncology pharmacists have not been sufficiently explained. Aim This study aimed to demonstrate direct CPS for patients physicians, assess potential impact of these on medical costs. Methods We retrospectively examined outpatients who underwent chemotherapy between January December 2016. Results In total, 1177 1050 pharmacists, respectively, were investigated. rates interventions performed...
Introduction: The main cause of slightly elevated human chorionic gonadotropin (HCG) after successful treatment male germ cell tumors is considered to be pituitary-derived HCG. It well known that HCG frequently detected in postmenopausal women. We evaluated the status serum men with gonadotropins, which were induced by androgen deprivation therapy, using commercially available assays. Materials and Methods: enrolled 44 patients prostate cancer, who underwent luteinizing-hormone releasing...
Abstract Purpose : In clinical practice, teicoplanin (TEIC) is typically administered at a trough concentration of 15–40 μg/mL. TEIC has protein binding rate approximately 90%, and its rarely exceeds 40 μg/ml. Nevertheless, an increase in the free blood may result renal dysfunction. However, relationship between occurrence dysfunction remains unclear. This study aimed to examine effect predicted concentrations on development Methods: retrospective included patients who underwent treatment...
In certain cases of rectal malignancy in which invasion is confined to the prostate and/or seminal vesicles, bladder-sparing surgery may be chosen instead total pelvic exenteration. However, even if bladder preserved, postoperative urinary dysfunction and vesicourethral anastomotic leakage are concern.
What is known and objective In Japan, ledipasvir/sofosbuvir, elbasvir/grazoprevir glecaprevir/pibrentasvir are recommended as first-line treatments for patients with untreated hepatitis C virus genotype 1. Although they have demonstrated a high efficacy in clinical trials, there no direct comparative studies. Clarification of their effectiveness safety real-world practice required. Therefore, we conducted retrospective multicentre study on the these direct-acting antivirals practice. Methods...