A5052843751- Knee injuries and reconstruction techniques
- Electrospun Nanofibers in Biomedical Applications
- RNA modifications and cancer
- Cellular Mechanics and Interactions
- RNA Research and Splicing
- Bone fractures and treatments
- Microfluidic and Bio-sensing Technologies
- Genomics and Chromatin Dynamics
- Tissue Engineering and Regenerative Medicine
- Skin and Cellular Biology Research
- Protein Structure and Dynamics
- Advanced biosensing and bioanalysis techniques
- Minimally Invasive Surgical Techniques
- Dendrimers and Hyperbranched Polymers
- Gold and Silver Nanoparticles Synthesis and Applications
- Periodontal Regeneration and Treatments
- Gastrointestinal disorders and treatments
- Neuroscience and Neural Engineering
- Cancer Cells and Metastasis
- Orthopaedic implants and arthroplasty
- Molecular Communication and Nanonetworks
- Advanced Sensor and Energy Harvesting Materials
- Advanced Polymer Synthesis and Characterization
- Bone Tissue Engineering Materials
- bioluminescence and chemiluminescence research
Rice University
2021-2024
University of Pennsylvania
2020-2022
Georgia Institute of Technology
2017-2019
Abstract Bone morphogenetic protein 2 (BMP-2)-loaded collagen sponges remain the clinical standard for treatment of large bone defects when there is insufficient autograft, despite associated complications. Recent efforts to negate comorbidities have included biomaterials and gene therapy approaches extend duration BMP-2 release activity. In this study, we compared sponge chondroitin sulfate glycosaminoglycan (CS-GAG) scaffolds as a delivery vehicle recombinant human (rhBMP-2) rhBMP-2...
Release of cargo molecules from cell-like nanocarriers can be achieved by chemical perturbations, including changes to pH and redox state via optical modulation membrane properties. However, little is known about the kinetics or products vesicle breakdown due limitations in real-time imaging at nanometer length scales. Using a library 12 single–single type photocleavable amphiphilic Janus dendrimers, we developed self-assembling light-responsive dendrimersome platform. A ortho-nitrobenzyl...
Abstract Cells harbor numerous mesoscale membraneless compartments that house specific biochemical processes and perform distinct cellular functions. These protein RNA-rich bodies are thought to form through multivalent interactions among proteins nucleic acids resulting in demixing via liquid-liquid phase separation (LLPS). Proteins harboring intrinsically disordered regions (IDRs) predominate organelles. However, it is not known whether IDR sequence alone can dictate the formation of...
ABSTRACT Age is a well‐known influential factor in bone healing, with younger patients generally healing fractures more rapidly and suffering fewer complications compared older patients. Yet the impact age has on response to current treatments, such as delivery of morphogenetic protein 2 (BMP‐2), remains poorly characterized. It unclear how or if therapeutic dosing BMP‐2 should be modified account for age‐related differences order minimize potential adverse effects consequently improve...
Abstract Microscale changes in tissue environment are translated to cell behavior and phenotype, yet the mechanisms behind how these phenotypic occur poorly understood. Here, we describe model chromatin, which stores genetic information within nucleus, as a dynamic nanomaterial whose configuration is modulated by chemo-mechanical cues microenvironment. Our findings indicate that physiologic can directly regulate chromatin architecture progenitor populations. Via direct experimental...
Laparoscopic surgery is a practice of minimally invasive (MIS) performed in the abdominal area. Prior to surgery, instead exposing target region air as typical conventional open “key holes” are opened for positioning ports, through which surgical tools (e.g. laparoscope, needle drivers, etc.) inserted. MIS therefore minimizes trauma and reduces risk hemorrhaging infection. also generates economic benefits such shorter hospitalization time patients better utilization operating rooms wards...
ABSTRACT The meniscus plays a critical role in knee mechanical function but is commonly injured given its central load bearing role. In the adult, repair limited, low number of endogenous cells, density matrix, and limited vascularity. Menisci are fibrocartilaginous tissues composed micro-/nano-fibrous extracellular matrix (ECM) mixture chondrocyte-like fibroblast-like cells. Here, we developed fibrous scaffold system that consists bioactive components (decellularized ECM (dME) within...
The meniscus plays a critical role in knee mechanical function but is commonly injured given its central load bearing role. In the adult, repair limited, low number of endogenous cells, density matrix, and limited vascularity. Menisci are fibrocartilaginous tissues composed micro-/nano- fibrous extracellular matrix (ECM) mixture chondrocyte-like fibroblast-like cells. Here, we developed scaffold system that consists bioactive components (decellularized ECM (dME) within poly(e-caprolactone)...