A5021499441- Neurobiology and Insect Physiology Research
- Neural dynamics and brain function
- Insect and Arachnid Ecology and Behavior
- Photoreceptor and optogenetics research
- Genetics, Aging, and Longevity in Model Organisms
- Physiological and biochemical adaptations
- Animal Behavior and Reproduction
- Plant and Biological Electrophysiology Studies
- Olfactory and Sensory Function Studies
University of Cambridge
2022-2024
Abstract Connections between neurons can be mapped by acquiring and analyzing electron microscopic (EM) brain images. In recent years, this approach has been applied to chunks of brains reconstruct local connectivity maps that are highly informative, yet inadequate for understanding function more globally. Here, we present the first neuronal wiring diagram a whole adult brain, containing 5×10 7 chemical synapses ∼130,000 reconstructed from female Drosophila melanogaster . The resource also...
High-resolution electron microscopy of nervous systems has enabled the reconstruction synaptic connectomes. However, we do not know sign for each connection (i.e., whether a is excitatory or inhibitory), which implied by released transmitter. We demonstrate that artificial neural networks can predict transmitter types presynapses from micrographs: network trained to six transmitters (acetylcholine, glutamate, GABA, serotonin, dopamine, octopamine) achieves an accuracy 87% individual...
Abstract The fruit fly Drosophila melanogaster combines surprisingly sophisticated behaviour with a highly tractable nervous system. A large part of the fly’s success as model organism in modern neuroscience stems from concentration collaboratively generated molecular genetic and digital resources. As presented our FlyWire companion paper 1 , this now includes first full brain connectome an adult animal. Here we report systematic hierarchical annotation ∼130,000-neuron including neuronal...
Abstract High-resolution electron microscopy of nervous systems enables the reconstruction connectomes. A key piece missing information from connectomes is synaptic sign. We show that for D. melanogaster , artificial neural networks can predict transmitter type released at synapses micrographs and thus add putative signs to connections. Our network discriminates between six transmitters (acetylcholine, glutamate, GABA, serotonin, dopamine, octopamine) with an average accuracy 87%/94%...
Costly punishment within social bonds manifests as both reactive penalties for transgressions and proactive sanctions against fair behaviors, yet a unified neurocomputational framework remains elusive. Combining neuroimaging computational modeling, this study examined how future interaction prospects-a key element of bonds-modulate punishment. Participants acted second- or third-party punishers, responding to allocation offers from individuals with without interactions. Results showed that...
Variations in neuronal connectivity occur widely nervous systems from invertebrates to mammals. Yet, it is unclear how variability originates, what extent and at time scales exists, functional consequences might carry. To assess inter- intraindividual variability, would be ideal analyze the same identified neuron across different brain hemispheres individuals. Here, using genetic labeling electron microscopy connectomics, we show that an inhibitory olfactory local interneuron, TC-LN,...