A5009412727- Genomics and Chromatin Dynamics
- Genetics, Bioinformatics, and Biomedical Research
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Nutrition, Genetics, and Disease
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Cellular transport and secretion
- Animal Genetics and Reproduction
- Genomics and Phylogenetic Studies
- Escherichia coli research studies
- Bacteriophages and microbial interactions
- Plant Molecular Biology Research
- Monoclonal and Polyclonal Antibodies Research
- Endoplasmic Reticulum Stress and Disease
- Growth Hormone and Insulin-like Growth Factors
- Viral gastroenteritis research and epidemiology
- Chromatin Remodeling and Cancer
- Herpesvirus Infections and Treatments
- Protein Degradation and Inhibitors
- Fungal and yeast genetics research
- Chromosomal and Genetic Variations
University of Oslo
2018-2025
University of Bergen
2004-2016
The Francis Crick Institute
2011
Uni Research (Norway)
2010
European Molecular Biology Laboratory
2001-2009
Sapienza University of Rome
2009
Norwegian Cancer Society
1999
European Bioinformatics Institute
1995
EEA1, a 162-kDa autoantigen associated with subacute cutaneous systemic lupus erythematosus, is coiled-coil protein localized to early endosomes and cytosol. At its C terminus, the contains cysteine-rich motif, which shared Vps27, Fab1, Vac1, yeast proteins implicated in membrane traffic (Mu, F. T., Callaghan, J. M., Steele-Mortimer, O., Stenmark, H., Parton, R. G., Campbell, P. L., McCluskey, J., Yeo, P., Tock, E. Toh, B. H. (1995) Biol. Chem. 270, 13503-13511). Here we show that this motif...
Genomes of animals as different sponges and humans show conservation global architecture. Here we that multiple genomic features including transposon diversity, developmental gene repertoire, physical order, intron-exon organization are shattered in the tunicate Oikopleura, belonging to sister group vertebrates retaining chordate morphology. Ancestral architecture animal genomes can be deeply modified may therefore largely nonadaptive. This rapidly evolving lineage thus offers unique...
Epigenesis is the process whereby daughters of a dividing cell retain chromatin state determined before division. The best-studied cases involve inheritance heterochromatic chromosomal domains, and little known about specific gene regulation by epigenetic mechanisms. Recent evidence shows that epigenesis pivots on methylation nucleosomes at histone 3 lysines 4, 9 or 27. Bioinformatics indicates mammals have several enzymes for each these methylations, including least six lysine 4...
Set3 is one of two proteins in the yeast Saccharomyces cerevisiae that, like Drosophila Trithorax, contains both SET and PHD domains. We found that forms a single complex, Set3C, with Snt1, YIL112w, Sif2, Cpr1, putative histone deacetylases, Hos2 NAD-dependent Hst1. Set3C includes independent deacetylase activities when assayed vitro. Homology searches suggest analog mammalian HDAC3/SMRT complex. represses genes early/middle sporulation program, including key meiotic regulators ime2 ndt80 ....
Linear motifs are short segments of multidomain proteins that provide regulatory functions independently protein tertiary structure. Much intracellular signalling passes through modifications at linear motifs. Many thousands motif instances, most notably phosphorylation sites, have now been reported. Although clearly very abundant, difficult to predict de novo in sequences due the difficulty obtaining robust statistical assessments. The ELM resource http://elm.eu.org/ provides an expanding...
The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding phosphatidylinositol 3‐phosphate (PI3P), which found mainly on endosomes. Here we review recent work that sheds light targeting PI3P‐containing membranes, and how these serve regulate multiple cellular functions.
Recent cloning of a cDNA ( UNG15 ) encoding human uracil-DNA glycosylase (UDG), indicated that the gene product M r = 33,800 contains an N-terminal sequence 77 amino acids not present in presumed mature form 25,800. This led to hypothesis N-termlnal might be involved intracellular targeting. To examine this hypothesis, we analysed UDG from nuclei, mitochondria and cytosol by western blotting high resolution gel filtration. An antibody recognises UNG protein detected all three forms,...