A5049090059- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bat Biology and Ecology Studies
- Genomics and Phylogenetic Studies
- PI3K/AKT/mTOR signaling in cancer
- Marine Ecology and Invasive Species
- Cancer-related gene regulation
- Marine Biology and Ecology Research
- Marine animal studies overview
- Identification and Quantification in Food
- Evolution and Paleontology Studies
- Ichthyology and Marine Biology
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Physiological and biochemical adaptations
- Genetic diversity and population structure
- Coral and Marine Ecosystems Studies
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Species Distribution and Climate Change
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Quinazolinone synthesis and applications
- Cephalopods and Marine Biology
Mission Therapeutics (United Kingdom)
2025
University of Cambridge
2020-2023
Queen Mary University of London
2012-2021
Université de Montpellier
2008-2018
Centre National de la Recherche Scientifique
2008-2018
Institut des Sciences de l'Evolution de Montpellier
2010-2018
École Pratique des Hautes Études
2018
Institut de Recherche pour le Développement
2018
Tissue regeneration is a multi-step process mediated by diverse cellular hierarchies and states that are also implicated in tissue dysfunction pathogenesis. Here we leveraged single-cell RNA sequencing combination with vivo lineage tracing organoid models to finely map the trajectories of alveolar-lineage cells during injury repair lung regeneration. We identified distinct AT2-lineage population, damage-associated transient progenitors (DATPs), arises alveolar found interstitial...
Evolution is typically thought to proceed through divergence of genes, proteins and ultimately phenotypes. However, similar traits might also evolve convergently in unrelated taxa owing selection pressures. Adaptive phenotypic convergence widespread nature, recent results from several genes have suggested that this phenomenon powerful enough drive recurrent evolution at the sequence level. Where homoplasious substitutions do occur these long been considered result neutral processes. studies...
Genomes of animals as different sponges and humans show conservation global architecture. Here we that multiple genomic features including transposon diversity, developmental gene repertoire, physical order, intron-exon organization are shattered in the tunicate Oikopleura, belonging to sister group vertebrates retaining chordate morphology. Ancestral architecture animal genomes can be deeply modified may therefore largely nonadaptive. This rapidly evolving lineage thus offers unique...
Abstract The evolution of cetaceans, from their early transition to an aquatic lifestyle subsequent diversification, has been the subject numerous studies. However, although higher-level relationships among cetacean families have largely settled, several aspects systematics within these groups remain unresolved. Problematic clades include oceanic dolphins (37 spp.), which experienced a recent rapid radiation, and beaked whales (22 not investigated in detail using nuclear loci. combined...
Tunicates are the closest relatives of vertebrates and widely used as models to study evolutionary developmental biology chordates. Their phylogeny, however, remains poorly understood, date, only 18S rRNA nuclear gene mitogenomes have been delineate major groups tunicates. To resolve their relationships provide a first estimate divergence times, we transcriptomic approach build phylogenomic dataset including all tunicate lineages, consisting 258 evolutionarily conserved orthologous genes...
Abstract Therapies that enhance antitumor immunity have altered the natural history of many cancers. Consequently, leveraging nonoverlapping mechanisms to increase immunogenicity cancer cells remains a priority. Using novel enzymatic inhibitor RNA methyltransferase METTL3, we demonstrate global decrease in N6-methyladenosine (m6A) results double-stranded (dsRNA) formation and profound cell-intrinsic interferon response. Through unbiased CRISPR screens, establish dsRNA-sensing signaling are...
Abstract Recent phylogenomic analyses have suggested tunicates instead of cephalochordates as the closest living relatives vertebrates. In direct contradiction with long accepted view Euchordates, this new phylogenetic hypothesis for chordate evolution has been object some skepticism. We assembled an expanded dataset focused on deuterostomes. Maximum‐likelihood using standard models and Bayesian CAT site‐heterogeneous mixture model amino‐acid replacement both provided unequivocal support...
Abstract Background Tunicates have been recently revealed to be the closest living relatives of vertebrates. Yet, with more than 2500 described species, details their evolutionary history are still obscure. From a molecular point view, tunicate phylogenetic relationships mostly studied based on analyses 18S rRNA sequences, which indicate several major clades at odds traditional class-level arrangements. Nonetheless, substantial uncertainty remains about and taxonomic status key groups such...
Abstract Next‐generation sequencing (NGS) technologies offer the opportunity for population genomic study of non‐model organisms sampled in wild. The transcriptome is a convenient and popular target such purposes. However, designing genetic markers from NGS data requires assembling gene‐coding sequences out short reads. This complex task owing to gene duplications, polymorphism, alternative splicing transcription noise. Typical programmes return thousands predicted contigs, whose connection...
Phylogenomics has revealed the existence of fast-evolving animal phyla in which amino acid substitution rate, averaged across many proteins, is consistently higher than other lineages. The reasons for such differences proteome-wide evolutionary rates are still unknown, largely because only a handful species offer within-species genomic data from molecular processes can be deduced. In this study, we use next-generation sequencing technologies and individual whole-transcriptome to gather...
Abstract Next Generation Sequencing technologies (NGS) are rapidly invading many evolutionary and ecological fields, such as phylogenomics, molecular evolution, population genomics ecology. Among the potential targets of NGS is transcriptome sequencing, a fast relatively cheap way to generate massive amounts coding sequence data, offering promising perspectives for analysis diversity in wild. A number ecology research groups therefore may switch from DNA‐based RNA‐based typing near future....
Tunicates represent a key metazoan group as the sister-group of vertebrates within chordates. The six complete mitochondrial genomes available so far for tunicates have revealed distinctive features. Extensive gene rearrangements and particularly high evolutionary rates been evidenced with regard to other This peculiar dynamics has hampered reconstruction tunicate phylogenetic relationships chordates based on mitogenomic data.In order further understand atypical genome tunicates, we...
During their evolutionary radiation, mammals have colonized diverse habitats. Arguably the subterranean niche is most inhospitable of these, characterized by reduced oxygen, elevated carbon dioxide, absence light, scarcity food, and a substrate that energetically costly to burrow through. Of all lineages transitioned niche, African mole-rats are one successful. Much ecological success can be attributed diet plant storage organs, which has allowed them colonize climatically varied habitats...
Abstract Dietary adaptation is a major feature of phenotypic and ecological diversification, yet the genetic basis dietary shifts poorly understood. Among mammals, Neotropical leaf-nosed bats (family Phyllostomidae) show unmatched diversity in diet; from putative insectivorous ancestor, phyllostomids have radiated to specialize on diverse food sources including blood, nectar, fruit. To assess whether diversification this group was accompanied by molecular adaptations for changing metabolic...
The transition to an aquatic lifestyle in cetaceans (whales and dolphins) resulted a radical transformation their sensory systems. Toothed whales acquired specialized high-frequency hearing tied the evolution of echolocation, whereas baleen evolved low-frequency hearing. More generally, all show adaptations for seeing underwater. To determine extent which these phenotypic changes have been driven by molecular adaptation, we performed large-scale targeted sequence capture 179 genes across...
Altered dystrophin expression was found in some tumors and recent studies identified a developmental onset of Duchenne muscular dystrophy (DMD). Given that embryogenesis carcinogenesis share many mechanisms, we analyzed broad spectrum to establish whether alteration evokes related outcomes. Transcriptomic, proteomic, mutation datasets from fifty tumor tissues matching controls (10,894 samples) 140 corresponding cell lines were analyzed. Interestingly, transcripts protein widespread across...
Recent studies have reported multiple cases of molecular adaptation in cetaceans related to their aquatic abilities. However, none these has included the hippopotamus, precluding an understanding whether adaptations occurred before or after they split from semi-aquatic sister taxa. Here, we obtained new transcriptomes hippopotamus and humpback whale, analysed together with available data eight other cetaceans. We identified more than 11 000 orthologous genes compiled a genome-wide dataset...
Abstract Background: Diffuse hemispheric glioma, H3 G34-mutant, is a pediatric-type high-grade glioma with limited treatment options and poor prognosis. RNA-modifying enzymes, including METTL3, are critical for the initiation maintenance of various cancers, brain tumors. We previously presented STM2457, first-in-class enzyme inhibitor targeting catalytic activity preventing m6A deposition on mRNA. Here, we show small-molecule inhibition METTL3 as novel therapeutic strategy G34-mutant...
Museums hold most of the world's valuable biological specimens and tissues collected, including type material that is often decades or even centuries old. Unfortunately, traditional museum collection storage methods were not designed to preserve nucleic acids held within material, reducing its potential viability value for many genetic applications. High-throughput sequencing technologies associated applications offer new opportunities obtaining sequence data from samples. In particular,...
Abstract Gene loss and gain during genome evolution are thought to play important roles in adaptive phenotypic diversification. Among mammals, bats possess the smallest genomes have evolved unique abilities of powered flight laryngeal echolocation. To investigate whether gene family has contributed downsizing diversification this group, we performed comparative evolutionary analyses complete proteome data for eight bat species, including echolocating non-echolocating forms, together with...