A5012437000- Aldose Reductase and Taurine
- Advanced Glycation End Products research
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Retinal Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Cardiac Ischemia and Reperfusion
- Blood properties and coagulation
- Species Distribution and Climate Change
- Alcohol Consumption and Health Effects
- Cardiovascular Health and Disease Prevention
- Diabetes Management and Research
- Neurological and metabolic disorders
- Neurological Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Diet, Metabolism, and Disease
- Cardiac electrophysiology and arrhythmias
- Metabolism and Genetic Disorders
- Coleoptera Taxonomy and Distribution
- Diabetic Foot Ulcer Assessment and Management
Queen Mary University of London
2018-2025
University College London
2023-2025
University of Arkansas at Fayetteville
2023-2024
Imperial College London
2018-2023
University of Sheffield
2021
Washington University in St. Louis
1996-2016
University of Michigan
1976-2015
University of Oxford
2015
National Society of Professional Engineers
2014
Boston Medical Center
2004
Increased blood flow and vascular leakage of proteins preferentially affect tissues that are sites diabetic complications in humans animals. These changes rats largely prevented by aminoguanidine. Glucose-induced nondiabetic also aminoguanidine NG-monomethyl-L-arginine (NMMA), an established inhibitor nitric oxide (NO·) formation from L-arginine. Aminoguanidine NMMA equipotent inhibitors interleukin-1 β-induced 1) nitrite (an oxidation product NO·) cGMP accumulation the rat β-cell insulinoma...
Quantitative electron microscopic studies of muscle capillary basement membrane are reported on 154 control subjects and 151 diabetics. In normal in diabetics significant thickening is observed as an aging phenomenon both sexes. Significant age-related sex differences width evident but not Observations suggest that probably most prior to the onset carbohydrate intolerance demonstrate magnitude incidence increase with longer known duration intolerance. Basement demonstrable a significantly...
Abstract Brief introduction: What are microclimates and why they important? Microclimate science has developed into a global discipline. is increasingly used to understand mitigate climate biodiversity shifts. Here, we provide an overview of the current status microclimate ecology biogeography in terrestrial ecosystems, where this field heading next. investigations We highlight latest research on interactions between organisms, including how influence individuals, through them populations,...
Anthropogenic climate change is projected to become a major driver of biodiversity loss, destabilizing the ecosystems on which human society depends. As planet rapidly warms, disruption ecological interactions among populations, species and their environment, will likely drive positive feedback loops, accelerating pace magnitude losses. We propose that, even without invoking such amplifying feedback, loss should increase nonlinearly with warming because non-uniform distribution biodiversity....
C-peptide, a cleavage product from the processing of proinsulin to insulin, has been considered possess little if any biological activity other than its participation in insulin synthesis. Injection human C-peptide prevented or attenuated vascular and neural (electrophysiological) dysfunction impaired Na + - K -dependent adenosine triphosphate tissues diabetic rats. Nonpolar amino acids midportion peptide were required for these effects. Synthetic reverse sequence (retro) all– d –amino acid...
Normal red cells deform markedly as they pass through the spleen and peripheral capillaries. In these studies, effects of Plasmodium falciparum infection maturation on deformability parasitized exposed to fluid shear stress in vitro were examined by means a rheoscope. Red containing early (ring) erythrocytic stage parasite have impaired at physiologic stresses, recover their normal shape more slowly. mature parasites (trophozoites or schizonts) exhibit no deformation under same conditions....
This study was undertaken to compare the ability of two guanidine compounds (aminoguanidine and methylguanidine), with different in vitro effects on NO synthase activity AGE formation, inhibit diabetic vascular dysfunction developing early after onset diabetes. In rats STZ-induced diabetes 5-wk duration, regional [125I]albumin permeation increased about two- threefold ocular tissues, sciatic nerve, aorta; general, both normalized albumin without affecting it controls. Methylguanidine only...
To determine whether nifedipine, a calcium antagonist, protects ischemic myocardium, conscious dogs were subjected to coronary occlusion and given nifedipine by intravenous infusion beginning 30 minutes after the onset of ischemia lasting for 24 hours while systemic arterial pressure, left atrial cardiac output monitored. Local myocardial perfusion at selected intervals was assessed with radioactive microspheres injected into atrium. In regions myocardium exhibiting moderately depressed flow...
Hemoglobin AIc concentration, fasting blood sugar, response to an oral glucose tolerance test, and skeletal muscle capillary basement membrane thickness were measured in diabetic patients. concentration correlates with both a test (r = 0.82, p less than 0.001) sugar 0.62, 0.001). The correlation of hemoglobin is independent (partial r 0.61, 0.005), whereas that probably reflects the relationship between levels 0.22, 0.05). do not correlate ( 0.15,
Morphological changes associated with mobilization of lipid were studied in epididymal adipose tissue from fasted and alloxan diabetic rats. In both groups animals a decrease content was accompanied by the formation complex frond-like cytoplasmic processes loops folds basement membrane which extended cell surfaces. These changes, evident after 1 day fasting, increased magnitude increasing weight loss. As decreased further, lipid-cytoplasmic interfaces became irregular convoluted. Cytoplasmic...
The present experiments were undertaken to examine the hypothesis that glucose-induced increased de novo synthesis of 1,2-diacyl-sn-glycerol (which has been observed in a number different tissues, including retinal capillary endothelial cells exposed elevated glucose levels vitro) and associated activation protein kinase C may play role mediating vascular functional changes. We report here twice daily instillation 30 mM over 10 d rat skin chamber granulation tissue model induces...
125I-labeled albumin permeation (IAP) has been assessed in various tissues spontaneously diabetic insulin-dependent female BB/W rats and male Sprague-Dawley with severe or mild forms of streptozocin-induced diabetes (SS-D MS-D, respectively). In SS-D, indices IAP were significantly increased vessels predisposed to vascular disease humans, including the eyes (anterior uvea, posterior retina), sciatic nerve, aorta, kidney, new formed after induction diabetes. No evidence was observed heart,...
Abstract There is a weak evidence base supporting the effective management of riparian ecosystems within tropical agriculture. Policies to protect buffers—strips non‐cultivated land alongside waterways—are vague and vary greatly between countries. From rapid appraisal, we find that buffers are beneficial hydrology, water quality, biodiversity some ecosystem functions in landscapes. However, effects on connectivity, carbon storage emissions reduction remain understudied. Riparian mediated by...
The major sources of error and variation in estimates basement membrane thickness (BMT) are attributable to variations conditions specimen preparation, errors magnification, sectioning artifacts related section tangential sectioning. A simplified method for estimating BMT, requiring only two measurements per vessel, is described justified theoretically from analysis a model system. chief merits the are: (1) estimate BMT obtained closely approximates true (2) minimized, (3) coefficients...
Abstract Logged and disturbed forests are often viewed as degraded depauperate environments compared with primary forest. However, they dynamic ecosystems 1 that provide refugia for large amounts of biodiversity 2,3 , so we cannot afford to underestimate their conservation value 4 . Here present empirically defined thresholds categorizing the logged forests, using one most comprehensive assessments taxon responses habitat degradation in any tropical forest environment. We analysed impact...