A5101629777- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Quinazolinone synthesis and applications
- Natural product bioactivities and synthesis
- Circular RNAs in diseases
- NF-κB Signaling Pathways
- Cholinesterase and Neurodegenerative Diseases
- Urban and spatial planning
- Cancer Treatment and Pharmacology
- Medicinal Plant Pharmacodynamics Research
- Synthesis of Indole Derivatives
- Nanoparticle-Based Drug Delivery
- Histone Deacetylase Inhibitors Research
- Sulfur-Based Synthesis Techniques
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Liver physiology and pathology
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Synthesis and bioactivity of alkaloids
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ubiquitin and proteasome pathways
Affiliated Hospital of Nantong University
2014-2024
Nantong University
2014-2024
Nanjing Tech University
2019
National Cheng Kung University
2017
Second Military Medical University
2009
Abstract Relapsed/refractory multiple myeloma patients with extramedullary disease (EMD) have unfavorable prognosis and lack effective therapy. Chimeric antigen receptor (CAR) T‐cell activities in EMD yet to be determined; how EMD‐specific microenvironment influences the clinical outcomes of CAR therapy remains great interest. In this prospective cohort study, histologically confirmed extra‐osseous were enrolled treated combined anti‐BCMA anti‐CD19 from May 2017 September 2023. Thirty‐one...
A new Cu(<sc>ii</sc>)-catalyzed formal [4 + 2] cycloaddition between quinone methides (QMs) including <italic>para</italic>-quinone (<italic>p</italic>-QMs) and <italic>ortho</italic>-quinone (<italic>o</italic>-QMs) electron-poor 3-vinylindoles was established.
Aberrant expression of long non-coding RNAs (lncRNAs) is closely associated with development and prognosis human cancers. LncRNA SNHG16 reportedly involved in cancer; however, its roles multiple myeloma (MM) remain unclear.In this study, we investigated the function molecular mechanisms MM. MM cells were transfected si-SNHG16 or si-NC. levels was measured by qRT-PCR. Cell proliferation monitored using MTS. Flow cytometry assay performed to measure cell cycle apoptosis. Luciferase reporter...
Long noncoding RNAs (lncRNAs) are dysregulated in cancer and involved oncogenic or tumor inhibitory processes. The aim of the study was to investigate expression pattern lncRNA XLOC_013703 multiple myeloma (MM) evaluate its biological role potential significance. We found that significantly decreased CD138 positive plasma cells serum MM patients compared normal controls, correlated with β2-MG, serum-free light chain (s-FLC) revised international staging system. RNA-fluorescence situ...
Tumor necrosis factor receptor-associated 6 (TRAF6) is an important E3 ubiquitin ligase, which key to immunity. TRAF6 has been implicated in the invasive growth and metastasis of various types cancer, including squamous cell carcinoma, gastric myelodysplastic syndromes acute myeloid leukemia. In present study, associations between multiple myeloma (MM) TRAF6, its downstream component nuclear factor-κB (NF-κB) bone marrow stromal cells (MSC) were investigated. The protein expression levels 18...
Delivering ageing-in-place in the high disaster risk communities- a comparative study of Tainan City and Hong Kong Since population ageing trend has increased rapidly beginning 21st Century, “ageing place” become core concept most related policies. Among all issues regarding ageing, vulnerability from natural disasters would be challenging. With increasing casualty reports older residents at high-disaster-risk areas, urgent responses to this threats enhance survival chances people under are...
This study was aimed to sort the side population (SP) cells from human multiple myeloma cell lines, then detect biological characteristics of those SP cells. After Hoechst33342 staining, intracellular fluorescence staining differences lines observed by microscopy. The fluorescence-activated sorting (FACS) technology used isolate and main (MP) cells; proliferative capacity in vitro determined growth curve; colony forming ability compared test. CD138 expression detected flow cytometry. ABCG2...