A5085706656- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Bone Metabolism and Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Cell death mechanisms and regulation
- Quinazolinone synthesis and applications
- Dendrimers and Hyperbranched Polymers
- Microscopic Colitis
- Neuroblastoma Research and Treatments
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Histone Deacetylase Inhibitors Research
- Multicomponent Synthesis of Heterocycles
- Protein Kinase Regulation and GTPase Signaling
- Bone health and treatments
- Protease and Inhibitor Mechanisms
- Autoimmune Bullous Skin Diseases
- Protein Degradation and Inhibitors
- 14-3-3 protein interactions
- Cancer Treatment and Pharmacology
Affiliated Hospital of Nantong University
2019-2025
Nantong University
2019-2025
To investigate the relative expression level and clinical significance of
Multiple myeloma (MM) is an incurable hematological malignancy, Dual-specificity phosphatase-1 (DUSP1) plays a crucial role in the initiation and progression of various tumors. Here, we aim to elucidate DUSP1 MM. mRNA expression was analyzed based on public datasets, protein determined by immunohistochemistry. The association between clinicopathological characteristics, as well its impact survival, were investigated. Protein-protein interaction gene set enrichment analysis performed. Low...
To investigate the effect of TBL1XR1 mutation on cell biological characteristics diffuse large B-cell lymphoma (DLBCL). The overexpression vector was constructed and DNA sequencing performed to determine status. apoptosis DLBCL line detected by flow cytometry TUNEL fluorescence assay; CCK-8 assay used detect proliferation; Transwell migration invasion; Western blot expression level epithelial-mesenchymal transition (EMT) related proteins. plasmid successfully constructed. in vitro...
Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive form of mature commonly found in elder males, but its genetic features are poorly understood. In this study, we had performed target-sequencing 360 lymphoma-related genes on 76 PT-DLBCL patients with median age 65 (33-89). Our data provide comprehensive understanding the landscape mutations small subset PT-DLBCL.
This study aimed to investigate whether annexin A7 (ANXA7) could promote the cell cycle, proliferation and adhesion-mediated drug resistance (CAM-DR) of multiple myeloma (MM) cells by up-regulating division cycle 5-like (CDC5L).As a result, ANXA7 expression was increased in serum MM patients CDC5L also lines.ANXA7 overexpression promoted U266 RPMI8226 cells.The nuclear antigen (PCNA), KI67, cyclin dependent kinase 1 (CDK1) cyclinB1 transfected consistent with changes cycle.In co-culture...
Abstract: Chimeric antigen receptor (CAR)-modified T cell therapy is increasingly administered for hematological malignancies. Cytokine release syndrome (CRS) a common and severe complication of CAR-T therapy. In the present case, 62-year-old male patient was diagnosed with relapsed refractory multiple myeloma (RRMM). Treated CART-CD19/BCMA therapy, his symptoms remitted, during which occasional but CRS associated coagulation disorder still appeared, as evidenced by coexistence huge...
Multiple myeloma (MM) remains a challenge to treat, and its precise pathogenic mechanisms have not been fully clarified. The present study aimed evaluate the relation between long non‑coding RNA transcription factor 7 (lnc‑TCF7) clinical features, as well prognosis of patients with MM, determine effects lnc‑TCF7‑knockdown on regulation (and regulatory mechanisms) MM progression. lnc‑TCF7 expression was detected in bone marrow plasma cells 86 30 healthy controls. In data were collected,...
Acute lymphoblastic leukemia (ALL) is a malignant disease characterized by lymphocytic B-line or T-line cells abnormally proliferating in the bone marrow extramedullary sites. BCR/ABL1 fusion protein patients with ALL accounts for acts 15-30% of B-lineage cases, usually adolescence. However, entire ABL1 gene deletion without rearrangement rare phenomenon patients. Here we describe first case female B-ALL patient. Relevant literature reviewed to explain association between and...
Renal insufficiency is one of the common complications in multiple myeloma (MM) and an independent factor indicating a poor prognosis. Cystatin C (Cys C) considered to be expected replace creatinine calculate glomerular filtration rate due its own characteristics. Gene expression analysis suggested that cystatin up-regulated nearly 50-fold patients with myeloma.To further clarify role myeloma, we retrospectively evaluated pretreatment levels 195 newly diagnosed through statistical...
Multiple myeloma (MM) is a fatal hematological malignancy and does not have adequate prognostic indicators. Previous studies indicate that CEP72 closely related to tumorigenesis tumor progression. However, the expression function of in multiple yet be elucidated.In this study, we explored correlation between clinicopathological characteristics as well impacts on survival MM patients. In addition, PPI, GSEA Chemotherapy drug resistance analysis identified possible mechanism.CEP72...
POEMS syndrome is a rare disorder which has been increasingly recognized. The clonal origin controversial. Some people argue that originates from abnormal plasma cell clones. So, treatment frequently targets the clone. Nevertheless, others believe both cells and B can be potential culprit in syndrome.A 65-year-old male came to emergency department of our hospital with complaints bilateral soles numbness weight loss for half year, abdominal distension month, chest tightness shortness breath...
Topic: 13. Myeloma and other monoclonal gammopathies - Biology & Translational Research Background: Dual-specificity phosphatase-1 (DUSP1) is one of the important members mitogen-activated protein kinase phosphatase (MKP) family, which plays a significant role in tumorigenesis development various human cancers. Aims: This study aimed to analyze expression level multiple myeloma (MM), investigate relationship between DUSP1 clinicopathological characteristics MM patients, its prognostic...