A5002057161- Physiological and biochemical adaptations
- Fish Ecology and Management Studies
- Aquaculture Nutrition and Growth
- Fish biology, ecology, and behavior
- Aquaculture disease management and microbiota
- Genetic diversity and population structure
- Ocean Acidification Effects and Responses
- High Altitude and Hypoxia
- Animal Behavior and Reproduction
- Animal Genetics and Reproduction
- Heat shock proteins research
- Evolution and Genetic Dynamics
- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Neurobiology and Insect Physiology Research
- Genetic and phenotypic traits in livestock
- Reproductive biology and impacts on aquatic species
- Bat Biology and Ecology Studies
- Fish Biology and Ecology Studies
- Molecular Biology Techniques and Applications
- Species Distribution and Climate Change
- thermodynamics and calorimetric analyses
- Cancer, Hypoxia, and Metabolism
- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
University of British Columbia
2016-2025
British Academy
2018
Google (United States)
2009-2017
Auburn University
2017
Truven Health Analytics (United States)
2015
University of California, Davis
2011
Stanford University
1995-2005
Rocky Mountain Biological Laboratory
2005
University of Waterloo
1999-2004
Heinrich Heine University Düsseldorf
2003
Lecture is prominent, but practices vary
Populations of common killifish, Fundulus heteroclitus, are distributed along the Atlantic coast North America through a steep latitudinal thermal gradient. We examined intraspecific variation in whole-animal tolerance and its relationship to heat shock response killifish from northern southern extremes species range. Critical maxima were significantly higher than fish by approximately 1.5 degrees C at wide range acclimation temperatures (from 2-34 C), critical minima differed above 22 C,...
Widespread recognition of the importance biological studies at large spatial and temporal scales, particularly in face many most pressing issues facing humanity, has fueled argument that there is a need to reinvigorate such physiological ecology through establishment macrophysiology. Following period when fields had been regarded as largely synonymous, this kind were relatively commonplace first half twentieth century. However, large‐scale work subsequently became rather scarce concentrated...
Anthropogenic environmental change is exposing animals to changes in a complex array of interacting stressors and already having important effects on the distribution abundance species. However, despite extensive examination isolation, knowledge combination limited. This lack information makes predicting responses organisms anthropogenic challenging. Here, we focus temperature hypoxia as fishes. A review available evidence suggests that act synergistically such small shifts one stressor...
SUMMARY. We identified five Na+/K+-ATPase α-isoforms in rainbow trout and characterized their expression pattern gills following seawater transfer. Three of these isoforms were closely related to other vertebrate α1 (designated α1a, α1b α1c),one isoform was α2 α2) the fifth α3 α3). α1c- α3-isoforms present all tissues examined, while others had tissue specific distributions. Four expressed (α1a, α1b, α1c at low levels freshwater did not change transfer 40% or 80% seawater. α1a differentially...
Maintenance of ion balance requires that ionoregulatory epithelia modulate flux in response to internal or environmental osmotic challenges. We have explored the basis this functional plasticity gills euryhaline killifish Fundulus heteroclitus. The expression patterns several genes encoding transport proteins were quantified after transfer from near-isosmotic brackish water [10 parts/thousand (ppt)] either freshwater (FW) seawater (SW). Many changes SW transient. Increased mRNA occurred 1...
The upregulation of gill Na+/K+-ATPase activity is considered critical for the successful acclimation salmonid fishes to seawater. present study examines mRNA expression two recently discovered alpha-subunit isoforms (alpha1a and alpha1b) in during seawater three species anadromous salmonids, which vary their salinity tolerance. Levels these were compared with protein abundance related tolerance each species. Atlantic salmon (Salmo salar) quickly regulated plasma Na+, Cl- osmolality levels...
Bar-headed geese (Anser indicus) fly at up to 9,000 m elevation during their migration over the Himalayas, sustaining high metabolic rates in severe hypoxia these altitudes. We investigated evolution of cardiac energy metabolism and O2 transport this species better understand molecular physiological mechanisms high-altitude adaptation. Compared with low-altitude (pink-footed barnacle geese), bar-headed had larger lungs higher capillary densities left ventricle heart, both which should...
In fishes, performance failure at high temperature is thought to be due a limitation on oxygen delivery (the theory of and capacity limited thermal tolerance, OCLTT), which suggests that tolerance hypoxia might functionally associated. Here we examined variation in among 41 families Atlantic salmon (Salmo salar), allowed us evaluate the association between these two traits. Both varied significantly there was significant positive correlation critical maximum (CTmax) supporting OCLTT concept....
As global temperatures rise, there is a growing need to understand the physiological mechanisms that determine an organism's thermal niche. Here, we test hypothesis increases in mitochondrial capacity with cold acclimation and adaptation are associated decreases tolerance using two subspecies of killifish (Fundulus heteroclitus) differ We assessed whole-organism metabolic rate, amount function acclimated several temperatures. Mitochondrial enzyme activities mRNA levels were greater fish from...
Climate change is predicted to lead increased average temperatures and greater intensity frequency of high low temperature extremes, but the evolutionary consequences for biological communities are not well understood. Studies adaptive evolution tolerance have typically involved correlative analyses natural populations or artificial selection experiments in laboratory. Field required provide estimates timing strength selection, enhance understanding genetics adaptation yield insights into...
Loss of aerobic scope at high and low temperatures is a physiological mechanism proposed to limit the thermal performance tolerance organisms, theory known as oxygen- capacity-limited (OCLTT). Eurythermal organisms maintain over wide ranges temperatures, but it unknown whether acclimation necessary this breadth. The objective study was examine changes in Fundulus heteroclitus, eurythermal fish, after acute exposure from 5° 33°C. range which nonzero similar acclimated acutely exposed...
Human activities are increasing both the frequency of hypoxic episodes and mean temperature aquatic ecosystems, but few studies have considered possibility that acclimation to one these stressors could improve ability cope with other stressor. Here, we used Atlantic killifish, Fundulus heteroclitus, test this hypothesis. Hypoxia tolerance was measured as time loss equilibrium in hypoxia (LOEhyp) at 0.4 kPa oxygen. Time LOEhyp declined from 73.3 ± 6.9 min 15 °C 2.6 3.8 23 °C, 30 no fish...
To investigate the influence of intensity telecommuting on employee health.Study design comprised a longitudinal analysis demographic data, medical claims, health risk assessment and remote connectivity hours.Data from Prudential Financial served as setting.Active employees ages 18 to 64 years who completed between 2010 2011 were study subjects.Measures included status intensity, eight indicators (obesity, depression, stress, tobacco use, alcohol abuse, poor nutrition, physical inactivity,...
Evolutionary biologists have long trained their sights on adaptation, focusing the power of natural selection to produce relative fitness advantages while often ignoring changes in absolute fitness. Ecologists generally taken a different tack, abundance and ranges that reflect Uniting these perspectives, we articulate various causes maladaptation review numerous examples occurrence. This indicates is reasonably common from both yet contrasting ways. That is, can appear strong perspective,...
Epigenetic mechanisms such as changes in DNA methylation have the potential to affect resilience of species climate change, but little is known about response methylome environmental temperature animals. Using reduced representation bisulfite sequencing, we assessed effects development and adult acclimation on levels threespine stickleback (Gasterosteus aculeatus). Across all treatments, identified 2130 differentially methylated cytosines distributed across genome. Both increases decreases...