A5100395764- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Organic Light-Emitting Diodes Research
- Photochromic and Fluorescence Chemistry
- Molecular Sensors and Ion Detection
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organic Electronics and Photovoltaics
- RNA Interference and Gene Delivery
- Crystallography and molecular interactions
- Conducting polymers and applications
- Supramolecular Chemistry and Complexes
- Perovskite Materials and Applications
- Molecular Junctions and Nanostructures
- Supramolecular Self-Assembly in Materials
- Light effects on plants
- RNA modifications and cancer
- Biosensors and Analytical Detection
- Geotechnical Engineering and Underground Structures
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Cancer-related molecular mechanisms research
- Microbial Metabolites in Food Biotechnology
- Polysaccharides and Plant Cell Walls
- Cyclopropane Reaction Mechanisms
Jianghan University
2014-2025
Union Hospital
2021-2025
Huazhong University of Science and Technology
2021-2025
Jilin Provincial Academy of Forestry Science
2025
Shanxi University
2019-2024
Shanghai Institute of Pharmaceutical Industry
2024
Western University
2010-2021
Third Affiliated Hospital of Sun Yat-sen University
2021
Sun Yat-sen University
2013-2021
Xi’an Jiaotong-Liverpool University
2020-2021
N6 -methyladenosine (m6 A) modification of mRNA mediates diverse cellular and viral functions. Infection with Epstein-Barr virus (EBV) is causally associated nasopharyngeal carcinoma (NPC), 10% gastric carcinoma, various B-cell lymphomas, in which the latent lytic phases both play vital roles. Here, we show that EBV transcripts exhibit differential m6 A human NPC biopsies, patient-derived xenograft tissues, cells at different infection stages. A-modified are recognized destabilized by YTHDF1...
Abstract Elucidating the effects of crystallization‐induced blue‐shift emission a newly synthesized di‐boron complex (DBC) by enhanced photoluminescence (PL) and electrochemiluminescence (ECL) in annihilation pathway was realized for first time. The 57 nm great enhancement crystalline lattice relative to DBC solution were attributed restriction intramolecular rotation (RIR) confirmed PL imaging, X‐ray diffraction, as well DFT calculations. It discovered that ECL at film/solution interfaces...
The efficacy of current therapies for ovarian cancer is limited due to the multilevel and complex tumor microenvironment (TME), which induces drug resistance progression in a single treatment regimen. Additionally, poor targeting insufficient tissue penetration are important constraints treatment. We constructed PH20-overexpressing cancer-associated fibroblast (CAF)-cancer hybrid-cell membrane vesicles (PH20/CCM) dual-targeted delivery carboplatin (CBP) siRNA p65 (sip65) loaded on poly...
Strand displacement reactions are important bricks for the construction of various DNA nanodevices, among which toehold-mediated strand reaction is most prevalently adopted. However, only a limited number tools could be used to finely regulate toehold reaction, thus restricting nanodevices from being more multifunctional and powerful. Herein, we developed regulation tool, Clip, achieved multiple regulatory functions, including subtle adjustment rates, allosteric displacement, selective...
B ‐lymphoma mouse Moloney leukemia virus insertion region 1 ( mi1), a member of the polycomb group, has elevated expression and is involved in pathogenesis various aggressive cancers, including nasopharyngeal carcinoma NPC ). To date, mechanisms underlying high mi1 remain obscure. gain new insights into transcriptional regulation BMI1 , we cloned characterized promoter . Luciferase reporter assays demonstrated that from −783 to +375 showed significant activity. With use series 5′‐deletion...
Rapid colorimetric detection of magnesium ions is demonstrated via a convenient approach, based on EcoRI-modified gold nanoparticles and specifically designed DNA duplex. EcoRI an enzyme obtained from certain strains Escherichia coli. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: The publisher responsible for content...
Two series of DDD and AAA hydrogen-bond arrays were synthesized that form triply-hydrogen-bonded double-helical complexes when combined in CDCl(3) solution. Derivatization the with electron-withdrawing groups increases complex association constants by up to a factor 30 those examined. electron donating substituents reveals similar magnitude effect on stabilities. The substitution both types are modeled quite satisfactorily (R(2) > 0.96 all cases) as free energy relationships respect sums...
Through a facile one-pot three-component reaction and subsequent acetylation strategy, novel greenish-blue fluorescent 4-imino-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile (IPPC) was synthesized. Electrochemiluminescence (ECL) of IPPC firstly found to produce efficient emission at 500 nm with reducing coreactants. Its very similar ECL PL spectra suggest that production is mainly from the monomeric excited states.
A novel electroluminescent material based on pyrrolo[3,2-<italic>b</italic>]pyrrole as skeleton and donor group dimesitylborons accept groups has been synthesized characterized by elemental analysis, mass spectrometry, NMR spectroscopy X-ray crystallography.
Radiation therapy (RT) remains the primary treatment modality for advanced cervical cancer, however, recurrence due to radioresistance presents a significant challenge. Cancer-associated fibroblasts (CAFs) within tumor microenvironment (TME) are key contributors this resistance, driven by their inherent and radiation-induced phenotypic adaptations. Addressing issue requires strategies specifically designed target CAFs enhance radiosensitivity. In study, we developed biomimetic metal–organic...
Recent advances in electrochemiluminescence (ECL) leveraging thermally activated delayed fluorescence (TADF) have highlighted its potential for near-unity exciton harvesting. However, there are still very limited examples of TADF-ECL emitters. We present a rigid diboron-embedded multiple-resonance TADF emitter, which exhibits blue-green emission at 493 nm with remarkably narrow bandwidth (FWHM = 22 nm) and minimized singlet-triplet energy gap (ΔEST 0.2 eV), achieving 67% photoluminescence...
A novel, photochromic N^C-chelate organoboron functionalized dipicolinic acid (H2L) has been designed and synthesized. Lanthanide(III) complexes based on this ligand (L) with the general formula [NBu4]3[LnL3] (Ln = Eu or Tb) were prepared. The new was found to be effective in both sensitizing photomodulating emission of a Eu(III) ion. photoisomerization conversion boryl chromophore attached lanthanide complex determined quantitative by NMR analysis La(III) analogue.
Molecular strands incorporating three hydrogen bond donor (D) or acceptor (A) heterocycles form highly stable double helical complexes through a complementary AAA–DDD array structure.
Lentinan has important applications in the food and medicine fields. Fermenting Lentinula edodes with Bacillus subtilis natto increased lentinan extraction yield by 87.13% greatly altered molecular structure antioxidant activity of lentinan. The uronic acid content from 2.08% to 4.33%. fermentation process did not affect monosaccharide composition lentinan, comprised more than 90% glucose residues. Fermentation significantly reduced weight its apparent structure. water solubility fermented...