A5016257433- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Genetic and phenotypic traits in livestock
- Histone Deacetylase Inhibitors Research
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Adipose Tissue and Metabolism
- Genomic variations and chromosomal abnormalities
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Metabolism, Diabetes, and Cancer
- Plant Pathogens and Fungal Diseases
- Genetic diversity and population structure
- Calcium signaling and nucleotide metabolism
- Botanical Research and Applications
- Cancer, Hypoxia, and Metabolism
- Animal Genetics and Reproduction
- Glycogen Storage Diseases and Myoclonus
- Molecular Biology Techniques and Applications
- Ubiquitin and proteasome pathways
- Fibroblast Growth Factor Research
- Congenital heart defects research
- Birth, Development, and Health
- RNA Research and Splicing
South China Agricultural University
2024-2025
Sun Yat-sen University
2023-2025
Ministry of Agriculture and Rural Affairs
2024
Northwest A&F University
2018-2020
Phylogeny and characteristics of ruminants Ruminants are a diverse group mammals that includes families containing well-known taxa such as deer, cows, goats. However, their evolutionary relationships have been contentious, the origins distinctive digestive systems headgear, including antlers horns (see Perspective by Ker Yang). To understand among ruminants, L. Chen et al. sequenced 44 species representing 6 performed phylogenetic analysis. From this analysis, they were able to resolve...
Myogenesis is a complex and precisely orchestrated process that highly regulated by several non-coding RNAs signal pathways. Circular (circRNAs) represent novel subclass of endogenous have been identified in multiple species tissues play vital role post-transcriptional regulation eukaryotes, but the precise molecular mechanism action remains largely unknown. Here, we screened candidate circRNA derived from SNX29 gene, termed circSNX29 our previous circRNAs sequencing data bovine skeletal...
Circular RNAs (circRNAs) are ubiquitous endogenous RNA found in various organisms that can regulate gene expression eukaryotes. However, little is known about potential roles for circRNAs muscle development. We analyzed circRNA sequencing data of bovine skeletal tissue and differential circTitin (circTTN) fetal adult tissue. then further studied the role circTTN Overexpression inhibition together elicited its promoting proliferation differentiation primary myoblasts. Mechanistically, showed...
Exercise-induced activation of adenosine monophosphate-activated protein kinase (AMPK) and substrate phosphorylation modulate the metabolic capacity mitochondria in skeletal muscle. However, key effector(s) AMPK regulatory mechanisms remain unclear. Here, we showed that folliculin interacting 1 (FNIP1) serine-220 (S220) controls mitochondrial function muscle fuel utilization during exercise. Loss FNIP1 resulted increased content augmented capacity, leading to enhanced exercise endurance...
Pitaya canker disease, caused by Neoscytalidium dimidiatum, is the primary threat to pitaya cultivation, significantly compromising fruit quality and reducing yield. WRKY transcription factors are essential regulators in plant pathogen recognition defense mechanisms, yet their specific roles development of disease remain largely unexplored. In this study, five genes (HmeWRKY33, HmeWRKY51, HmePR1, HmeHsp70, HmeSERK) associated with were identified through RNA-Seq analysis. The expression...
Despite of favorable characteristics high protein, low fat, and free-pollution, yak meat has intrinsically poor performance in tenderness color, which is ever challenging sector. To this end, a three-way cross system was first developed for quality beef the Tibetan Plateau using Angus cattle ( Bos taurus) as terminal sire to mate with 1/2 (F1) generated from♂Qaidam × ♀yak grunniens). The withers height, chest girth, body weight 1/4 (F2) were all great higher than that P < 0.01), especially...
Abstract Background Mammalian or mechanistic target of rapamycin complex 1 (mTORC1) is an effective therapeutic for diseases such as cancer, diabetes, aging, and neurodegeneration. However, efficient tool monitoring mTORC1 inhibition in living cells tissues lacking. Results We developed a genetically encoded sensor called TORSEL. This changes its fluorescence pattern from diffuse to punctate when 4EBP1 dephosphorylation occurs interacts with eIF4E. TORSEL can specifically sense the...
Abstract Accumulating evidence indicates that metabolic enzymes can directly couple signals to transcriptional adaptation and cell differentiation. Glycogen synthase 1 (GYS1), the key enzyme for glycogenesis, is a nucleocytoplasmic shuttling protein compartmentalized in cytosol nucleus. However, spatiotemporal regulation biological function of nuclear GYS1 (nGYS1) microcompartments remain unclear. Here, we show dynamically reorganizes into condensates under conditions glycogen depletion or...
Copy number variations (CNVs) have been identified as another important structural variation of genome. In recent years, a large amount CNVRs in humans and animals. However, association dosage effects studies CNVs are very limited. Apolipoprotein L3 (APOL3) gene plays central role modulating transcription is located within CNVR that encompasses quantitative trait locis (QTLs) for economic traits like meat quality. Herein, we analyzed the CNV polymorphism APOL3 421 individuals from five...
Abstract Max dimerization protein 3 (MXD3) belongs to the MYC superfamily of basic helix‐loop‐helix leucine zipper transcription factors, and MXD3‐MAX heterodimers can bind promoters target genes modulate their expression. The aim this study was determine MXD3 mRNA expression levels in various cattle tissues comprising heart, liver, spleen, lung, kidney, Longissimus dorsi muscle subcutaneous fat Chinese Qinchuan Xianan breeds. RT‐qPCR data showed that gene variably expressed between all at...
Abstract DNA methylation, which can affect the expression level of genes, is one most vital epigenetic modifications in mammals. Fibroblast growth factor receptor 1 ( FGFR1 ) plays an important role muscle development; however, methylation promoter has not been studied to date cattle. Our study focused on and its effect bovine myoblast proliferation differentiation. We identified core by using luciferase reporter assays; we then reverse transcription quantitative polymerase chain reaction,...
SUMMARY Mammalian or mechanistic target of rapamycin complex 1 (mTORC1) is a clinically effective therapeutic for diseases such as cancer, diabetes, aging, and neurodegeneration, yet an efficient tool to monitor mTORC1 inhibition in living cells tissues still lacking. Here we devised genetically encoded reporter termed mTIR that exhibits highly contrasted fluorescence puncta pattern response inhibition. specifically senses physiological, pharmacological genetic signaling tissues....